Integrated Chemical Environment data updates
NICEATM’s Integrated Chemical Environment (ICE) provides data and tools to help develop, assess, and interpret chemical safety tests. The March 2022 ICE 3.6 update added quality control annotations to curated high-throughput screening (cHTS) data and provided flat files for easy download of entire data sets via the ICE webpages. Implementation of REST APIs in the July 2022 ICE 3.7 update enabled users to access ICE data more easily outside of the ICE environment. Other updates and improvements to ICE data sets during 2022 and 2023 include:
- References for acute oral toxicity data.
- Endpoints for skin sensitization data.
- Addition and harmonization of endocrine data.
- Harmonization of structure and data fields in dermal irritation/corrosion data.
- Updates of OPERA predictions from OPERA version 2.8.
- Addition of exposure prediction data from EPA’s SEEM3.
NICEATM is developing an annotation scheme for HTS assays that will provide biological context to the cHTS data and enable toxicological interpretation. The scheme incorporates annotations from the Open Biological and Biomedical Ontology Foundry, a harmonized and interoperable database consisting of multiple knowledge areas to encompass a broader range of biologic and toxicologic processes. An abstract describing the annotation scheme (Hill et al.) has been accepted for a poster presentation at the SOT 2024 annual meeting. NICEATM is also aligning the ICE cHTS annotations to the OECD’s Harmonized Template 201.