Skip to Main Navigation
Skip to Page Content
Share This:

ICCVAM Mission and Vision

ICCVAM is leading development of a strategic roadmap to establish new approaches for evaluating the safety of chemicals and medical products in the United States


ICCVAM's mission is to facilitate development, validation, and regulatory acceptance of new and revised regulatory test methods that reduce, refine, and replace the use of animals in testing while maintaining and promoting scientific quality and the protection of human health, animal health, and the environment.


ICCVAM's goals:

  • To be recognized as a leading authority on test method development and validation both within the federal government and internationally
  • To foster the 3R's of animal use (replace, reduce, and refine) by:
    • Identifying key alternative test methods that will replace, reduce, or refine animal use in testing
    • Facilitating the validation and acceptance of alternative methods by federal agencies
    • Promoting high-quality science as the basis of national and international regulatory policy
    • Setting and harmonizing international standards for scientific validation of alternative test methods
    • Promoting awareness and adoption of scientifically validated test methods by regulatory agencies both nationally and internationally
  • To develop internal and collaborative capacity to:
    • Ensure the scientific quality and integrity of its work
    • Implement reliable processes and operating procedures that are credible, effective and efficient
    • Build national and international partnerships with governmental and nongovernmental groups, including academia, industry, advocacy groups, and other key stakeholders
    • Secure the necessary human and financial resources to effectively carry out its mission


Significant changes to the focus and priorities of NICEATM and ICCVAM (see editorial by NIEHS and NTP Director Linda Birnbaum, Environmental Health Perspectives, February 2013) occurred in 2013. These changes better aligned ICCVAM and NICEATM with the vision laid out by the National Academy of Sciences in the 2007 National Research Council report Toxicity Testing in the 21st Century: A Vision and a Strategy.

ICCVAM and NICEATM developed a “A New Vision and Direction for ICCVAM” describing the initial steps towards this goal. The document discussed:

  • ICCVAM priority setting and scientific areas for immediate resource investment
  • Plans to improve communications with stakeholders and the public
  • Exploration of new paradigms for validation and utilization of alternative toxicological methods

In addition, ICCVAM stated the intent of its member agencies to take a more active role in priority setting and operations of the Committee and to devote more effort to fewer focus areas.

ICCVAM made this document available in draft form for comment in September 2013. Attendees at that month’s meeting of the Scientific Advisory Committee on Alternative Toxicological Methods discussed the document and proposed initial steps.