Public Health Impact

The Office of Environmental Health Hazard Assessment (OEHHA) is announcing the availability of a draft document for public review summarizing the noncancer reference exposure levels (RELs) for 1,4-Dichlorobenzene, as part of the Air Toxics Hot Spots program. RELs are airborne concentrations of a chemical that are not anticipated to result in adverse non–cancer health effects for specified exposure durations in the general population, including sensitive subpopulations.

National Toxicology Program (NTP). 2008. NTP technical report on the toxicology and carcinogenesis studies of formamide (CASRN 75-12-7) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 541. https://ntp.niehs.nih.gov/go/tr541abs

National Toxicology Program (NTP). 2014. Testis-mineralization. Nonneoplastic Lesion Atlas. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/mineral/index.htm

OEHHA will convene a meeting of the Developmental and Reproductive Toxicant Identification Committee (DARTIC). At this meeting the DARTIC will consider the possible listing of bisphenol S (BPS) based on male reproductive toxicity under the Safe Drinking Water and Toxic Enforcement Act of 1986, codified at Health and Safety Code section 25249.5 et seq. (Proposition 65). BPS is on the Proposition 65 list for reproductive toxicity, based on the female reproductive endpoint. A 45-day public comment period was held from September 27 to November 12, 2024 on the hazard identification document entitled “Evidence on the Male Reproductive Toxicity of Bisphenol S”.

National Toxicology Program (NTP). 2015. Handbook for preparing report on carcinogens monographs. Office of the Report on Carcinogens, National Institute of Environmental Health Sciences. https://ntp.niehs.nih.gov/ntp/roc/handbook/roc_handbook_508.pdf

National Toxicology Program (NTP). 2017. NTP research report on biological activity of bisphenol A (BPA) structural analogues and functional alternatives. Research Triangle Park, NC: National Toxicology Program. Research Report 4. https://doi.org/10.22427/NTP-RR-4

OEHHA will convene a meeting of the Carcinogen Identification Committee (CIC) for possible listing of vinyl acetate under the Safe Drinking Water and Toxic Enforcement Act of 1986, codified at Health and Safety Code section 25249.5 et seq. (Proposition 65). A 45-day public comment period was held from October 4 to November 18, 2024 on the hazard identification document for vinyl acetate.

National Toxicology Program (NTP). 2015. Handbook for preparing report on carcinogens monographs. Office of the Report on Carcinogens, National Institute of Environmental Health Sciences. https://ntp.niehs.nih.gov/ntp/roc/handbook/roc_handbook_508.pdf

National Toxicology Program (NTP). 1999. Historical controls. F344 rats 1984-1994 19 oral feed route. https://ntp.niehs.nih.gov/ntp/historical_controls/nih-07_1999/r_hcrpt_rte19991223.rpt

National Toxicology Program (NTP). 2017a. G06: Ames summary data. Chemical Effects in Biological Systems (CEBS). Research Triangle Park, North Carolina: US Department of Health and Human Services. https://doi.org/10.22427/NTP-DATA-DTXSID3021431

National Toxicology Program (NTP). 2017b. G04: In vivo micronucleus summary data of vinyl acetate in Fischer 344 Rats. Chemical Effects in Biological Systems (CEBS). Research Triangle Park, North Carolina: US Department of Health and Human Services. https://doi.org/10.22427/NTP-DATA-DTXSID3021431

NTP (National Toxicology Program). 2021. Report on Carcinogens, fifteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc15

As part of EPA's high-priority efforts to reduce childhood lead exposure, and in accordance with a U.S. Court of Appeals for the Ninth Circuit 2021 opinion, EPA is finalizing its proposal to lower the dust-lead hazard standards to any reportable level as analyzed by a laboratory recognized by EPA's National Lead Laboratory Accreditation Program (NLLAP). EPA's lead-based paint (LBP) regulations do not compel property owners or occupants to evaluate their property for LBP hazards or to take control actions, but if a LBP activity such as an abatement is performed, then EPA's regulations set requirements for doing so. EPA is also finalizing changes to lower the post-abatement dust-lead clearance levels to 5 micrograms per square foot ([micro]g/ft\2\), 40 [micro]g/ft\2\, and 100 [micro]g/ft\2\ for floors, window sills and troughs respectively, the current levels in New York City. Due to feedback from public comments, EPA is also finalizing changes to the nomenclature to adopt the terms dust-lead reportable levels (DLRL) and dust-lead action levels (DLAL). Given the decoupling of the action levels from the reportable levels, EPA is finalizing revisions to the definition of abatement so that the recommendation for action based on dust-lead applies when dust-lead loadings are at or above the action levels, rather than the hazard standards, as has been the case historically. The dust-lead hazard standards will be described as DLRL moving forward (i.e., after publication of this final rule) and the dust-lead clearance levels will be described as DLAL. Additionally, EPA is finalizing several other amendments, including revising the definition of target housing to conform with the statute.

This final rule is effective January 13, 2025.

National Toxicity Program (NTP). 2012. Monograph on health effects of low-level lead. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf

NTP (National Toxicology Program). 2021. Lead and lead compounds. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.  https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/lead.pdf

The Food and Drug Administration (FDA) received objections and requests for a public hearing submitted by the Environmental Defense Fund, Learning Disabilities Association of America, Center for Food Safety, Center for Environmental Health, Center for Science in the Public Interest, Breast Cancer Prevention Partners, Defend our Health, and Alaska Community Action on Toxics on the denial of a food additive petition (FAP 6B4815) requesting that FDA revoke specified regulations to no longer provide for the food contact use of 28 ortho-phthalates. FDA is overruling the objections and denying the requests for a public hearing.

National Toxicology Program (NTP). 2021. NTP technical report on the toxicology and carcinogenesis studies of di(2-ethylhexyl) phthalate (CASRN 117-81-7) administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats. Research Triangle Park, NC: National Toxicology Program. Technical Report 601. https://doi.org/10.22427/NTP-TR-601

In December 2023, the U.S. Environmental Protection Agency (EPA) requested comment on the proposed the Lead and Copper Rule Improvements (LCRI), which informed the revisions to the National Primary Drinking Water Regulation (NPDWR) for lead and copper. After consideration of public comment on the LCRI, and consistent with the provisions set forth under the Safe Drinking Water Act (SDWA), the EPA is finalizing revisions to the NPDWR for lead and copper. In this rule, the agency is finalizing requirements for drinking water systems to replace lead and certain galvanized service lines. The final rule also removes the lead trigger level, reduces the lead action level to 0.010 mg/L, and strengthens tap sampling procedures to improve public health protection and simplify implementation relative to the 2021 Lead and Copper Rule Revisions (LCRR). Further, this final rule strengthens corrosion control treatment, public education and consumer awareness, requirements for small systems, and sampling in schools and child care facilities. The final rule will significantly reduce the adverse human health impacts of exposure to toxic lead in drinking water.

National Toxicity Program (NTP). 2012. Monograph on health effects of low-level lead. Research Triangle Park, NC: National Toxicology Program.
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf

The Office of Environmental Health Hazard Assessment (OEHHA) has amended Title 27, California Code of Regulations 25607.2(b), to provide an additional safe harbor warning option for businesses that cause significant exposures to acrylamide from food products.

NTP (National Toxicology Program). 2021. Acrylamide. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acrylamide.pdf

The Environmental Protection Agency (EPA) is proposing to add 16 individually listed per- and polyfluoroalkyl substances (PFAS) and 15 PFAS categories to the Toxics Release Inventory (TRI) list of toxic chemicals subject to reporting under the Emergency Planning and Community Right-to-Know Act (EPCRA) and the Pollution Prevention Act (PPA) to comply with the National Defense Authorization Act for Fiscal Year 2020 (NDAA). EPA also addresses how PFAS categories should be treated. Separately, EPA discusses what events may trigger the automatic addition of a PFAS to the TRI pursuant to the NDAA. This discussion does not propose to list chemicals to TRI pursuant to the NDAA, but rather describes what EPA documents and activities involving PFAS would trigger an automatic addition under the NDAA.

National Toxicology Program (NTP). 2016. NTP monograph on immunotoxicity associated with exposure to perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS). Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/pfoa_pfos/pfoa_pfosmonograph_508.pdf

The Office of Environmental Health Hazard Assessment (OEHHA) is recommending that the State Water Resources Control Board (Water Board) establish the notification level (NL) for perfluorohexanoic acid (PFHxA) at 1 part per billion (equivalent to 1 microgram per liter). This recommendation is based on OEHHA’s development of a health-protective concentration intended to prevent noncancer effects, including thyroid, nasal cavity, liver, and developmental toxicity.

National Toxicology Program (NTP). 2016. NTP monograph on immunotoxicity associated with exposure to perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS). Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/pfoa_pfos/pfoa_pfosmonograph_508.pdf

National Toxicology Program (NTP). 2016. NTP technical report on the toxicology studies of green tea extract in F344/NTac rats and B6C3F1/N mice and toxicology and carcinogenesis studies of green tea extract in Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 585. https://doi.org/10.22427/NTP-TR-585

National Toxicology Program (NTP). 2022. NTP technical report on the toxicity studies of perfluoroalkyl carboxylates (perfluorohexanoic acid, perfluorooctanoic acid, perfluorononanoic acid, and perfluorodecanoic acid) administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised). Research Triangle Park, NC: National Toxicology Program. Toxicity Report 97. https://doi.org/10.22427/NTP-TOX-97

National Toxicology Program (NTP). 2022. NTP technical report on the toxicity studies of perfluoroalkyl sulfonates (perfluorobutane sulfonic acid, perfluorohexane sulfonate potassium salt, and perfluorooctane sulfonic acid) administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised). Research Triangle Park, NC: National Toxicology Program. Toxicity Report 96. https://doi.org/10.22427/NTP-TOX-96

National Toxicity Program (NTP). 2019. Risk of bias tool. https://ntp.niehs.nih.gov/go/riskbias

The Environmental Protection Agency (EPA or Agency) is proposing to address the unreasonable risk of injury to human health presented by 1-bromopropane (1–BP) (CASRN 106–94–5), also known as n-propyl bromide, under its conditions of use as documented in EPA’s August 2020 Risk Evaluation for 1–BP and the December 2022 Revised Risk Determination for 1–BP prepared under the Toxic Substances Control Act (TSCA).

National Toxicology Program (NTP). 1989a. NTP technical report on the toxicology and carcinogenesis studies of tribromomethane (bromoform) (CASRN 75-25-2) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 350. 1-194. https://ntp.niehs.nih.gov/go/tr350abs

National Toxicology Program (NTP). 1989b. NTP technical report on the toxicology and carcinogenesis studies of bromoethane (CASRN 74-96-4) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 363. https://ntp.niehs.nih.gov/go/tr363abs

National Toxicology Program (NTP). 1990. NTP technical report on the toxicology and carcinogenesis studies of glycidol (CASRN 556-52-5) in F344/N rats and B6C3Fi mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 374. (NIH Pub No. 90-2829) https://ntp.niehs.nih.gov/go/tr374abs

National Toxicology Program (NTP). 2011a, 2011b. NTP technical report on the toxicology and carcinogenesis studies of 1-bromopropane (CASRN 106-94-5) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 564. NIH Publication No. 11-5906. pp. 1-190.  (ISSN 0888-8051). https://ntp.niehs.nih.gov/go/tr564abs

National Toxicology Program (NTP). 2013a. Draft report on carcinogens monograph for 1-bromopropane. Research Triangle Park, NC: National Toxicology Program. http://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2013/march/draftroc1bpmonograph_508.pdf

National Toxicology Program (NTP). 2013b. Report on Carcinogens monograph on 1-bromopropane.  (pp. 1-168). (NIH Publication No. 13-5982). Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/thirteenth/monographs_final/1bromopropane_508.pdf

NTP (National Toxicology Program). 2014. Report on Carcinogens, thirteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

The IRIS Program is excited to announce the final IRIS Toxicological Review of Hexavalent Chromium [Cr(VI)]. The Cr(VI) assessment characterizes Cr(VI) as a human carcinogen and as a noncancer human health hazard. The IRIS assessment of Cr(VI) will serve as a critical source of toxicity information for EPA, state and local health agencies, other federal agencies, and international health organizations.The final toxicity assessment is posted on the IRIS website.

National Toxicology Program (NTP). 1978. Bioassay of 2,5-toluenediamine sulfate for possible carcinogenicity. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health. https://ntp.niehs.nih.gov/go/tr126abs

National Toxicology Program (NTP). 1996. Final report on the reproductive toxicity of potassium dichromate (CASRN 7778-50-9) administered in diet to BALB/c mice. Research Triangle Park: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/racb95002abs

National Toxicology Program (NTP). 1996. Final report on the reproductive toxicity of potassium dichromate (hexavalent) (CASRN 7778-50-9) administered in diet to SD rats. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/racb95001abs

National Toxicology Program (NTP). 1997. Final report on the reproductive toxicity of potassium dichromate (hexavalent) (CASRN 7778-50-9) administered in diet to BALB/c mice. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/racb94014abs

National Toxicology Program (NTP). 2005. Immunotoxicity of hexavalent chromium in female B6C3F1 mice. Protocol: RF-HCR28-1 M-DW. RTP: NIEHS.

National Toxicology Program (NTP). 2006. Immunotoxicity of hexavalent chromium in female Fischer 344 rats. Protocol: RFHCR-28-2R-DW. RTP: NIEHS.

National Toxicology Program (NTP). 2006. Immunotoxicity of hexavalent chromium in female Sprague Dawley rats. Protocol: RF-HCR-28-1R-DW. RTP: NIEHS

National Toxicology Program (NTP). 2007. NTP technical report on the toxicity studies of sodium dichromate dihydrate (CASRN 7789-12-0) administered in drinking water to male and female F344/N rats and B6C3F1 mice and male BALB/c and am3-C57BL/6 mice. (Toxicity Report Series Number 72; NIH Publication No. 07-5964). Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tox072abs

National Toxicology Program (NTP). 2008. NTP technical report on the toxicology and carcinogenesis studies of sodium dichromate dihydrate (CASRN 7789-12-0) in F344/N rats and B6C3F1 mice (drinking water studies). Research Triangle Park, NC. Technical Report 546. https://ntp.niehs.nih.gov/go/tr546abs

National Toxicology Program (NTP). 2010. NTP technical report on the toxicology and carcinogenesis studies of chromium picolinate monohydrate (CASRN 27882-76-4) in F344/N rats and B6C3F1 mice (feed studies). (NTP TR 556; NIH Publication No. 10-5897). Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr556abs

National Toxicology Program (NTP). 2011. Report on Carcinogens, twelfth edition, (pp. 507). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health. https://ntp.niehs.nih.gov/go/roc

National Toxicology Program (NTP). 2014. NTP technical report on the toxicology studies of cobalt metal (CASRN 7440-48-4) in F344/N rats and B6C3F1/N mice and toxicology and carcinogenesis studies of cobalt metal in F344/NTac rats and B6C3F1/N mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 581. https://ntp.niehs.nih.gov/go/tr581abs

National Toxicology Program (NTP). 2020. Organ sites with neoplasia: number of test articles associated with site-specific neoplasia that produced positive, clear or some evidence of carcinogenicity. Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). https://cebs.niehs.nih.gov/organsites/

The Safe Drinking Water Act (SDWA) requires the U.S. Environmental Protection Agency (EPA or the agency) to conduct a review every six years of existing national primary drinking water regulations (NPDWRs) and determine which, if any, are appropriate for revision. The purpose of the review, called the Six-Year Review, is to evaluate available information for regulated contaminants to determine if any new information on health effects, treatment technologies, analytical methods, occurrence, exposure, implementation, and/or other factors provides a basis to support a regulatory revision that would improve or strengthen public health protection. While EPA has recently completed several significant revisions to existing regulations and other regulatory revisions are currently underway, based on this periodic review of all NPDWRs, there are no additional candidates for regulatory revision at this time.

National Toxicology Program (NTP). 2023. NTP Board of Scientific Counselors working group report on the draft state of the science monograph and the draft meta-analysis manuscript on fluoride. Research Triangle Park, NC: U.S. Department of Health and Human Services, National Institutes of Health, National Institute of Environmental Health Sciences. https://ntp.niehs.nih.gov/events/past?type=&&date=2023-05-16

The Office of Environmental Health Hazard Assessment is announcing the availability of a draft document for review by the Scientific Review Panel on Toxic Air Contaminants. This draft summarizes the carcinogenicity data and presents the derivation of a cancer inhalation unit risk factor (IUR) for isoprene, as part of the Air Toxics Hot Spots program. Cancer IURs are used to estimate lifetime cancer risks associated with inhalation exposure to a carcinogen.

National Toxicology Program (NTP). 2023. Historical controls. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/data/controls

National Toxicology Program (NTP). 2021. Isoprene. Report on Carcinogens, Fifteenth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/isoprene.pdf

National Toxicology Program (NTP). 1999. NTP technical report on the toxicity studies of isoprene (CASRN 78-79-5) administered by inhalation to F344/N rats and B6C3F1/N mice. Research Triangle Park, NC: National Toxicology Program. Technical Report 486. https://ntp.niehs.nih.gov/go/tr486abs

National Toxicology Program (NTP). 1994. NTP technical report on the toxicology and carcinogenesis studies of isoprene (CASRN 78-79-5) in F344/N rats (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Toxicity Report 31. https://ntp.niehs.nih.gov/go/tox031abs

The U.S. Food and Drug Administration (FDA) is revoking the regulation authorizing the use of brominated vegetable oil (BVO) in food. Brominated vegetable oil (BVO) is a vegetable oil that is modified with bromine. The agency concluded that the intended use of BVO in food is no longer considered safe after the results of studies conducted in collaboration with the National Institutes of Health (NIH) found the potential for adverse health effects in humans.

Woodling KA, Chitranshi P, Jacob CC, Loukotková L, Von Tungeln LS, Olson GR, Patton RE, Francke S, Mog SR, Felton RP, Beland FA, Zang Y, Gamboa da Costa G. Toxicological evaluation of brominated vegetable oil in Sprague Dawley rats. Food Chem Toxicol. 2022 Jul;165:113137. https://doi.org/10.1016/j.fct.2022.113137

OSHA is amending the Hazard Communication Standard (HCS) to conform to the United Nations’ Globally Harmonized System of Classification and Labelling of Chemicals (GHS), primarily Revision 7 (Rev. 7), address issues that arose during the implementation of the 2012 update to the HCS, and provide better alignment with other U.S. agencies and international trading partners, while enhancing the effectiveness of the standard. Consistent with Executive Order 13563 and the Regulatory Flexibility Act, which call for assessment and, where appropriate, modification and improvement of existing rules, OSHA has reviewed the existing HCS. The agency has determined that the revisions in this final rule will enhance the effectiveness of the HCS by ensuring employees are appropriately apprised of the chemical hazards to which they may be exposed, thus reducing the incidence of chemical-related occupational illnesses and injuries. The modifications to the standard include revised criteria for classification of certain health and physical hazards, revised provisions for updating labels, new labeling provisions for small containers, new provisions related to trade secrets, technical amendments related to the contents of safety data sheets (SDSs), and related revisions to definitions of terms used in the standard. DATES: This final rule is effective July 19, 2024. The incorporation by reference of certain publications listed in this final rule is approved by the Director of the Federal Register as of July 19, 2024. The incorporation by reference of certain other publications listed in the rule was approved by the Director as of July 15, 2019.

NTP (National Toxicology Program). 2021. Report on carcinogens, fifteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc15

In this advance notice of proposed rulemaking (ANPRM), EPA is soliciting information from the public asEPA considers proposing a future rule on adding certain per- and polyfluoroalkyl substances (PFAS) tothe list of toxic chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA) and section 6607 of the Pollution Prevention Act (PPA). In this ANPRM, EPA outlines what PFAS are, why the Agency is considering adding certain PFAS to EPCRA section 313, what listing actions are being considered, who may be required to report, the currentunderstanding of hazard concerns for PFAS, EPA’s hazard assessments on PFAS, and other information available on these chemicals. In considering a chemical for addition to the EPCRA section 313 list, EPA bases its listing decision on the chemical’s hazard (i.e., toxicity), not the risk (i.e., toxicity plus potential exposures) related to that chemical. EPA is requesting comment on which, if any, PFAS should be evaluated for listing, how to list them, and what would be appropriate reporting thresholds given their persistence and bioaccumulation potential. Lastly, EPA asks for any additional data to inform the Agency’s evaluation and determination of which PFAS may meet the EPCRA section 313 listing criteria.

NTP. Per- and polyfluoroalkyl substances (PFAS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). https://ntp.niehs.nih.gov/go/PFAS

The Environmental Protection Agency (EPA or the Agency) is finalizing a rule to address the unreasonable risk of injury to health presented by methylene chloride under its conditions of use. TSCA requires that EPA address by rule any unreasonable risk of injury to health or the environment identified in a TSCA risk evaluation and apply requirements to the extent necessary so that the chemical no longer presents unreasonable risk. EPA’s final rule will, among other things, prevent serious illness and death associated with uncontrolled exposures to the chemical by preventing consumer access to the chemical, restricting the industrial and commercial use of the chemical while also allowing for a reasonable transition period where an industrial and commercial use of the chemical is being prohibited, provide a time-limited exemption for a critical or essential use of methylene chloride for which no technically and economically feasible safer alternative is available, and protect workers from the unreasonable risk of methylene chloride while on the job. DATES: This final rule is effective on July 8, 2024.

NTP (National Toxicology Program). 2021. Report on carcinogens, fifteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc15

National Toxicology Program (NTP). 1986. NTP technical report on the toxicology and carcinogenesis studies of dichloromethane (methylene chloride) (CASRN 75-09-2) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 306. https://ntp.niehs.nih.gov/go/tr306abs

Pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act (‘‘CERCLA’’ or ‘‘Superfund’’), the Environmental Protection Agency (EPA) is designating two per- and polyfluoroalkyl substances (PFAS)— perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), including their salts and structural isomers—as hazardous substances. The Agency reached this decision after evaluating the available scientific and technical information about PFOA and PFOS and determining that they may present a substantial danger to the public health or welfare or the environment when released. The Agency also determined that designation is warranted based on a totality of the circumstances analysis, including an analysis of the advantages and disadvantages of designation. DATES: Effective July 8, 2024.

National Toxicology Program (NTP). 2020. NTP technical report on the toxicology and carcinogenesis studies of perfluorooctanoic acid (CASRN 335-67-1) administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats. Research Triangle Park, NC: National Toxicology Program. Technical Report 598. https://doi.org/10.22427/NTP-TR-598

National Toxicology Program (NTP). 2022. NTP technical report on the toxicity studies of perfluoroalkyl carboxylates (perfluorohexanoic acid, perfluorooctanoic acid, perfluorononanoic acid, and perfluorodecanoic acid) administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised). Research Triangle Park, NC: National Toxicology Program. Toxicity Report 97. https://doi.org/10.22427/NTP-TOX-97

National Toxicology Program (NTP). 2022. NTP technical report on the toxicity studies of perfluoroalkyl sulfonates (perfluorobutane sulfonic acid, perfluorohexane sulfonate potassium salt, and perfluorooctane sulfonic acid) administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised). Research Triangle Park, NC: National Toxicology Program. Toxicity Report 96. https://doi.org/10.22427/NTP-TOX-96

In March 2023, the U.S. Environmental Protection Agency (EPA) proposed and requested comment on the National Primary Drinking Water Regulation (NPDWR) and health-based Maximum Contaminant Level Goals (MCLGs) for six per- and polyfluoroalkyl substances (PFAS): perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), hexafluoropropylene oxide dimer acid (HFPO-DA, commonly known as GenX Chemicals), and perfluorobutane sulfonic acid (PFBS). After consideration of public comment and consistent with the provisions set forth under the Safe Drinking Water Act (SDWA), the EPA is finalizing NPDWRs for these six PFAS. Through this action, the EPA is finalizing MCLGs for PFOA and PFOS at zero. Considering feasibility, the EPA is promulgating individual Maximum Contaminant Levels (MCLs) for PFOA and PFOS at 4.0 nanograms per liter (ng/L) or parts per trillion (ppt). The EPA is also finalizing individual MCLGs and is promulgating individual MCLs for PFHxS, PFNA, and HFPO-DA at 10 ng/L. In addition to the individual MCLs for PFHxS, PFNA, and HFPO-DA, in consideration of the known toxic effects, dose additive health concerns and occurrence and likely co-occurrence in drinking water of these three PFAS, as well as PFBS, the EPA is finalizing a Hazard Index (HI) of 1 (unitless) as the MCLG and MCL for any mixture containing two or more of PFHxS, PFNA, HFPO-DA, and PFBS. Once fully implemented, the EPA estimates that the rule will prevent thousands of deaths and reduce tens of thousands of serious PFAS-attributable illnesses.

National Toxicology Program (NTP). 2020. NTP technical report on the toxicology and carcinogenesis studies of perfluorooctanoic acid (CASRN 335-67-1) administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats. Research Triangle Park, NC: National Toxicology Program. Technical Report 598. https://doi.org/10.22427/NTP-TR-598

National Toxicology Program (NTP). 2021. Report on carcinogens, fifteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc15

NTP. Potassium perfluorohexanesulfonate (3871-99-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). DOI: https://doi.org/10.22427/NTP-DATA-DTXSID3037709

NTP. Perfluorodecanoic acid (335-76-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). DOI: https://doi.org/10.22427/NTP-DATA-DTXSID3031860

The Environmental Protection Agency (EPA) is promulgating new greenhouse gas (GHG) emissions standards for model year (MY) 2032 and later heavy-duty highway vehicles that phase in starting as early MY 2027 for certain vehicle categories. The phase in revises certain MY 2027 GHG standards that were established previously under EPA's Greenhouse Gas Emissions and Fuel Efficiency Standards for Medium- and Heavy-Duty Engines and Vehicles--Phase 2 rule ("HD GHG Phase 2"). This document also updates discrete elements of the Averaging Banking and Trading program, including providing additional flexibilities for manufacturers to support the implementation of the Phase 3 program balanced by limiting the availability of certain advanced technology credits initially established under the HD GHG Phase 2 rule. EPA is also adding warranty requirements for batteries and other components of zero-emission vehicles and requiring customer-facing battery state-of- health monitors for plug-in hybrid and battery electric vehicles. In this action, we are also finalizing additional revisions, including clarifying and editorial amendments to certain highway heavy-duty vehicle provisions and certain test procedures for heavy-duty engines.

NTP (National Toxicology Program). 2016. Report on carcinogens, fourteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

National Toxicology Program (NTP). 2019. NTP monograph on the systematic review of traffic-related air pollution and hypertensive disorders of pregnancy. Research Triangle Park, NC: National Toxicology Program. NTP Monograph 07. https://doi.org/10.22427/NTP-MGRAPH-7

California has adopted a new hexavalent chromium (Chromium 6) maximum contaminant level (MCL) of 10 parts per billion (ppb) for drinking water. This is the second time the state established the MCL for Chromium 6. The first MCL in 2014 was invalidated through a court ruling for not adequately documenting economic feasibility. California is the only state to set its own MCL for Chrome 6 and to previously set an MCL of 50 ppb for total chromium that was lower than the federal total chromium MCL of 100 ppb.

National Toxicity Program (NTP). 2019. Risk of bias tool. https://ntp.niehs.nih.gov/go/riskbias

National Toxicity Program (NTP). 2008. NTP technical report on the toxicology and carcinogenesis studies of chromium picolinate monohydrate (CASRN 27882-76-4) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 556. https://ntp.niehs.nih.gov/go/tr556abs

National Toxicology Program (NTP). 2007. NTP technical report on the toxicity studies of sodium dichromate dihydrate (CASRN 7789-12-0) administered in drinking water to male and female F344/N rats and B6C3F1 mice and male BALB/c and am3-C57BL/6 mice. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 72. https://ntp.niehs.nih.gov/go/tox72abs

National Toxicology Program (NTP). 2008. NTP technical report on the toxicology and carcinogenesis studies of sodium dichromate dihydrate (CASRN 7789-12-0) in F344/N rats and B6C3F1 mice (drinking water studies) (pp. 1-192). Research Triangle Park, NC: National Toxicology Program. Technical Report 546. NIH Publication No. 08-5887. https://ntp.niehs.nih.gov/go/tr546abs

Under the Clean Air Act, the Environmental Protection Agency (EPA) is establishing new, more protective emissions standards for criteria pollutants and greenhouse gases (GHG) for light-duty vehicles and Class 2b and 3 ("medium-duty") vehicles that will phase-in over model years 2027 through 2032. In addition, EPA is finalizing GHG program revisions in several areas, including off-cycle and air conditioning credits, the treatment of upstream emissions associated with zero-emission vehicles and plug-in hybrid electric vehicles in compliance calculations, medium-duty vehicle incentive multipliers, and vehicle certification and compliance. EPA is also establishing new standards to control refueling emissions from incomplete medium-duty vehicles, and battery durability and warranty requirements for light- duty and medium-duty electric and plug-in hybrid electric vehicles. EPA is also finalizing minor amendments to update program requirements related to aftermarket fuel conversions, importing vehicles and engines, evaporative emission test procedures, and test fuel specifications for measuring fuel economy.

NTP (National Toxicology Program). 2016. Report on carcinogens, fourteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

National Toxicology Program (NTP). 2019. NTP monograph on the systematic review of traffic-related air pollution and hypertensive disorders of pregnancy. Research Triangle Park, NC: National Toxicology Program. NTP Monograph 07. https://doi.org/10.22427/NTP-MGRAPH-7

The Mine Safety and Health Administration (MSHA) is amending its existing standards to better protect miners against occupational exposure to respirable crystalline silica, a significant health hazard, and to improve respiratory protection for miners from exposure to airborne contaminants. MSHA's final rule also includes other requirements to protect miner health, such as exposure sampling, corrective actions to be taken when a miner's exposure exceeds the permissible exposure limit, and medical surveillance for metal and nonmetal mines.

National Toxicology Program (NTP). 2000. Fact sheet: the report on carcinogens - 9th edition. News Release. National Toxicology Program, Department of Health, and Human Services.

NTP (National Toxicology Program). 2016. Silica, crystalline (respirable size). Report on carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/silica.pdf

On April 16, 2024, the U.S. Environmental Protection Agency and the Agency for Toxic Substances and Disease Registry are releasing the Synthetic Turf Field Recycled Tire Crumb Rubber Characterization Research Final Report: Part 2 -Tire Crumb Rubber Exposure Characterization. The report can be found https://www.epa.gov/chemical-research/federal-research-recycled-tire-crumb-used-playing-fields-and-playgrounds.

This report is part of the Federal Research Action Plan (FRAP) on Recycled Tire Crumb Used on Playing Fields and Playgrounds, a multi-agency research effort launched in 2016 by EPA, the Centers for Disease Control and Prevention/Agency for Toxic Substances and Disease Registry (CDC/ATSDR), and the Consumer Product Safety Commission (CPSC) to characterize the chemicals associated with tire crumb rubber and to identify the ways in which people may be potentially exposed to those chemicals based on their activities on synthetic turf fields.

National Toxicology Program (NTP). 2019. NTP research report on the chemical and physical characterization of recycled tire crumb rubber. Research Triangle Park, NC: National Toxicology Program. Research Report 11. https://doi.org/10.22427/NTP-RR-11

National Toxicology Program (NTP). 2019. NTP research report on synthetic turf/recycled tire crumb rubber: characterization of the biological activity of crumb rubber in vitro. Research Triangle Park, NC: National Toxicology Program. Research Report 12. https://doi.org/10.22427/NTP-RR-12

National Toxicology Program (NTP). 2019. NTP research report on synthetic turf/recycled tire crumb rubber: feasibility study in support of non-inhalation in vivo exposures of synthetic turf/recycled tire crumb rubber. Research Triangle Park, NC: National Toxicology Program. Research Report 13. https://doi.org/10.22427/NTP-RR-13

National Toxicology Program (NTP). 2019. NTP research report on synthetic turf/recycled tire crumb rubber: 14-day exposure characterization studies of crumb rubber in female mice housed on mixed bedding or dosed via feed or oral gavage. Research Triangle Park, NC: National Toxicology Program. Research Report 14. https://doi.org/10.22427/NTP-RR-14

OEHHA has adopted and published Public Health Goals (PHGs) for PFOA and PFOS in drinking water.

The PHG of 0.007 parts per trillion (ppt) for PFOA is based on kidney cancer in humans and the PHG of 1 ppt for PFOS is based on liver and pancreatic tumors in laboratory animals. The PHGs are set at a level of risk of one additional cancer case per one million persons exposed over a lifetime. The document also presents health-protective drinking water concentrations for noncancer health effects. The noncancer health-protective concentrations are 3 ppt for PFOA, based on increased risk of liver damage in humans and 2 ppt for PFOS, based on increased total cholesterol in humans.

National Toxicology Program (NTP). 2016. NTP monograph on immunotoxicity associated with exposure to perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS). Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/go/PFAS

National Toxicology Program (NTP). 2022. NTP technical report on the toxicity studies of perfluoroalkyl carboxylates (perfluorohexanoic acid, perfluorooctanoic acid, perfluorononanoic acid, and perfluorodecanoic acid) administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised). Research Triangle Park, NC: National Toxicology Program. Toxicity Report 97. https://doi.org/10.22427/NTP-TOX-97

National Toxicology Program (NTP). 2022. NTP technical report on the toxicity studies of perfluoroalkyl sulfonates (perfluorobutane sulfonic acid, perfluorohexane sulfonate potassium salt, and perfluorooctane sulfonic acid) administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised). Research Triangle Park, NC: National Toxicology Program. Toxicity Report 96. https://doi.org/10.22427/NTP-TOX-96

National Toxicity Program (NTP). 2019. Risk of bias tool. https://ntp.niehs.nih.gov/go/riskbias 

National Toxicology Program (NTP). 2019c. NTP historical controls report. National Toxicology Program, US Department of Health and Human Services. https://ntp.niehs.nih.gov/go/historical_controls

National Toxicology Program (NTP). 2020. NTP technical report on the toxicology and carcinogenesis studies of perfluorooctanoic acid (CASRN 335-67-1) administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats. Research Triangle Park, NC: National Toxicology Program. Technical Report 598. https://doi.org/10.22427/NTP-TR-598

The Office of Environmental Health Hazard Assessment (OEHHA) is announcing the availability of a draft document for public review summarizing the carcinogenicity data and deriving a cancer inhalation unit risk factor (IUR) for isoprene, as part of the Air Toxics Hot Spots program. Cancer IURs are used to estimate lifetime cancer risks associated with inhalation exposure to a carcinogen.

National Toxicology Program (NTP). 2023. NTP historical controls report. National Toxicology Program, US Department of Health and Human services. https://ntp.niehs.nih.gov/go/historical_controls

National Toxicology Program (NTP). 1995. NTP technical report on the toxicity studies of isoprene (CASRN 78-79-5) administered by inhalation to F344/N rats and B6C3F1 mice. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 31. https://ntp.niehs.nih.gov/go/tox31abs

National Toxicology Program (NTP). 1999. NTP technical report on the toxicology and carcinogenesis studies of isoprene (CASRN 78-79-5) in F344/N rats (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 486. https://ntp.niehs.nih.gov/go/tr486abs 

NTP (National Toxicology Program). 2021. Isoprene. Report on carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service https://ntp.niehs.nih.gov/ntp/roc/content/profiles/isoprene.pdf

The Office of Environmental Health Hazard Assessment (OEHHA) is proposing to update the Proposition 65 No Significant Risk Level (NSRL) for ethylene oxide by amending Title 27, California Code of Regulations, section 25705(b). The proposed updated NSRL for ethylene oxide is 0.058 micrograms per day.

National Toxicology Program (NTP). 1987. NTP technical report on the toxicology and carcinogenesis studies of ethylene oxide (CASRN 75-21-8) in B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 326. https://ntp.niehs.nih.gov/go/tr326abs

National Toxicology Program (NTP 2019). Risk of bias tool. National Toxicology Program. https://ntp.niehs.nih.gov/go/riskbias. Accessed: 10/13/21

The Environmental Protection Agency (EPA or the Agency) is proposing to amend its regulation under the Resource Conservation and Recovery Act (RCRA) by adding nine specific per-and polyfluoroalkyl substances (PFAS), their salts, and their structural isomers, to its list of hazardous constituents. These nine PFAS are perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorobutanesulfonic acid (PFBS), hexafluoropropylene oxidedimer acid (HFPO–DA or GenX), perfluorononanoic acid (PFNA), perfluorohexanesulfonic acid (PFHxS), perfluorodecanoic acid (PFDA), perfluorohexanoic acid (PFHxA), and perfluorobutanoic acid (PFBA).

NTP (2016). NTP monograph immunotoxicity associated with exposure to perfluorooctanoic acid or perfluorooctane sulfonate. National Toxicology Program, Research Triangle Park, NC. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/pfoa_pfos/pfoa_pfosmonograph_508.pdf

NTP (National Toxicology Program). 2019. pathology peer review of liver findings for H28548: subchronic toxicity 90 day gavage study in mice (DuPont-18405-1307). Study Number WIL-189225. National Institute of Environmental Health Sciences, NTP Pathology Working Group, Research Triangle Park, NC. https://hero.epa.gov/hero/index.cfm/reference/details/reference_id/6985027

The Office of Environmental Health Hazard Assessment (OEHHA) has added bisphenol S (BPS) to the Proposition 65 list as a reproductive toxicant (female reproductive endpoint). This listing was done via the “State’s Qualified Experts” mechanism, based on the Developmental and Reproductive Toxicant Identification Committee’s (DARTIC) determination that this chemical was clearly shown to cause female reproductive toxicity.

National Toxicology Program (NTP). 2015. Handbook for preparing report on carcinogens monographs. Office of the Report on Carcinogens, National Institute of Environmental Health Sciences. https://ntp.niehs.nih.gov/ntp/roc/handbook/roc_handbook_508.pdf

National Toxicology Program (NTP). 2017. NTP research report on biological activity of bisphenol A (BPA) structural analogues and functional alternatives. Research Triangle Park, NC: National Toxicology Program. Research Report 4. https://doi.org/10.22427/NTP-RR-4

The Office of Environmental Health Hazard Assessment (OEHHA) is announcing the availability of a draft document describing a proposed health-protective concentration (HPC) for noncancer effects of hexavalent chromium (Cr(VI)) in drinking water, as part of the update to the Cr(VI) Public Health Goal (PHG).

National Toxicity Program (NTP). 2019. Risk of bias tool. https://ntp.niehs.nih.gov/go/riskbias 

National Toxicity Program (NTP). 2008. NTP technical report on the toxicology and carcinogenesis studies of chromium picolinate monohydrate (CASRN 27882-76-4) in F344/N rats and B6C3F1 mice (feed studies), NTP TR 556. https://ntp.niehs.nih.gov/go/tr556abs

National Toxicology Program (NTP).  2007. NTP technical report on the toxicity studies of sodium dichromate dihydrate (CASRN 7789-12-0) administered in drinking water to male and female F344/N rats and B6C3F1 mice and male BALB/c and am3-C57BL/6 mice. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 72. https://ntp.niehs.nih.gov/go/tox72abs

National Toxicology Program (NTP). 2008. NTP technical report on the toxicology and carcinogenesis studies of sodium dichromate dihydrate (CASRN 7789-12-0) in F344/N rats and B6C3F1 mice (drinking water studies) (pp. 1-192). Research Triangle Park, NC: National Toxicology Program. Technical Report 546. NIH Publication No. 08-5887. https://ntp.niehs.nih.gov/go/tr546abs

The Centers for Disease Control and Prevention (CDC), as part of its continuing effort to reduce public burden and maximize the utility of government information, invites the general public and other federal agencies the opportunity to comment on a proposed and/or continuing information collection, as required by the Paperwork Reduction Act of 1995.This notice invites comment on a proposed information collection project titled Blood Lead Surveillance System (BLSS). The National Center for Environmental Health (NCEH) is leading a three-year Extension for two CDC information collections, one for childhood blood lead surveillance by NCEH and another for adult blood lead surveillance by the National Institute for Occupational Safety and Health (NIOSH).

National Toxicity Program (NTP). 2012. Monograph on health effects of low-level lead. Research Triangle Park, NC: National Toxicology Program.
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf

Safe harbor levels, which include No Significant Risk Levels (NSRLs) for cancer-causing chemicals and Maximum Allowable Dose Levels (MADLs) for chemicals causing reproductive toxicity, have been established for many of the chemicals listed under Proposition 65. Exposure levels and discharges to drinking water sources that are below the safe harbor levels are exempt from the requirements of Proposition 65. In some instances, enforcement actions may have resulted in negotiated exposure levels relative to specific settlement agreements. Please visit the Attorney General's Proposition 65 web site at https://ag.ca.gov/prop65 (link is external) for further information about specific enforcement actions.

National Cancer Institute (NCI, 1980). Bioassay of 4,4'-0xydianiline for possible carcinogenicity. Carcinogenesis Technical Report Series No. 205. NIH Publication No. 80-1761. US Department of Health and Human Services, NCI Carcinogenesis Testing Program, and National Toxicology Program. https://ntp.niehs.nih.gov/go/tr205

National Toxicology Program (NTP, 1982). NTP technical report on the toxicology and carcinogenesis studies of D & C red 9 in F344/N rats and B6C3F1 mice (feed study). NTP Technical Report Series No. 225. NIH Publication No. 82-1781. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr225
 
National Toxicology Program (NTP, 1983). NTP technical report on the toxicology and carcinogenesis studies of 4,4'-methylenedianiline dihydrochloride in F344/N rats and B6C3F1 mice (drinking water studies). NTP Technical Report Series No. 248. NTIS Publication No. PB 83238824. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr248
 
National Toxicology Program (NTP, 1985). NTP technical report on the toxicology and carcinogenesis studies of chlorodibromomerhane in F344/N rats and B6C3F1 mice (gavage studies). NTP Technical Report Series No. 282. NIH Publication No. 85-2538. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr282
 
National Toxicology Program (NTP, 1986). NTP technical report on the toxicology and carcinogenesis studies of chlorinated paraffins (C12. 60% chlorine) in F344/N rats and B6C3F1 mice (gavage studies). NTP Technical Report Series No. 308. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr308

National Toxicology Program (NTP, 1986). NTP technical report on the toxicology and carcinogenesis studies of 3-chloro-2-methy/propene in F344/N rats and B6C3F1 mice (gavage studies). NTP Technical Report Series No. 300. NIH Publication No. 86-2556. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr300 

National Toxicology Program (NTP, 1986). NTP technical report on the toxicology and carcinogenesis studies of C.l. basic red 9 monohydrochloride in F344/N rats and B6C3F1 mice (feed studies). NTP Technical Report Series No. 196. NlH Publication No. 86-2541. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr196
 
National Toxicology Program (NTP, 1986). NTP technical report on the toxicology and carcinogenesis studies of diglycidyl resorcinol ether in F344/N rats and B6C3F1 mice (gavage studies). NTP Technical Report Series No. 257. NIH Publication No. 87-2513. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr257
 
National Toxicology Program (NTP, 1986). NTP technical report on the toxicology and carcinogenesis studies of dimethylvinyl chloride (1-chloro-2-methyl-propene) in F344/N rats and B6C3F1 mice (gavage studies). NTP Technical Report Series No. 316. NIH Publication No. 86­ 2572. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr316
 
National Toxicology Program (NTP, 1986). NTP technical report on the toxicology and carcinogenesis studies of disperse blue 1 (a commercial dye containing approximately 50% 1,4,5,8-tetra amino anthraquinone, 30% other compounds structurally related to 1,4,5,8-tetra amino anthraquinone and 20% water in F344/N rats and B6C3F1 mice (feed studies). NTP Technical Report Series No. 299. NIH Publication No. 86-2555. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr299 

National Toxicology Program (NTP, 1986). NTP technical report on the toxicology and carcinogenesis studies of HC blue 1 in F344/N rats and B6C3F1 mice (feed studies). NTP Technical Report Series; No. 271. NTIS Publication No. PB 86-114683. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr271
 
National Toxicology Program (NTP, 1986). NTP technical report on the toxicology and carcinogenesis studies of toluene diisocyanate in F344/N rats and B6C3F1 mice (gavage studies). NTP Technical Report Series No. 251. NTIS Publication No. 87115176. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr251
 
National Toxicology Program (NTP, 1987). NTP technical report on the toxicology and carcinogenesis studies of chlorendic acid in F344 rats and B6C3F1 mice (feed studies). NTP Technical Report Series No. 304. N1H Publication No. 87-2560, US Department of Health and Human Services (DHEW), NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr304
 
National Toxicology Program (NTP, 1989). NTP technical report on the toxicology and carcinogenesis studies of hexachloroethane in F344/N rats (gavage studies). NTP Technical Report Series No. 361. NTIS Publication No. 89-2816. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr361

National Toxicology Program (NTP, 1991). Chemical status report. US Department of Health and Human Services, NTP, Research Triangle Park, NC. 

The Office of Environmental Health Hazard Assessment (OEHHA) has adopted a No Significant Risk Level (NSRL) of 0.13 micrograms per day for exposures to antimony trioxide by the inhalation route (adopted in Title 27, Cal. Code of Regs., Section 25705(b)). NSRLs provide guidance for determining when a warning is required for exposures to chemicals listed as causing cancer.

National Toxicology Program (NTP). 2017. NTP technical report on the toxicology and carcinogenesis studies of antimony trioxide (CASRN 1309-64-4) in Wistar Han [Crl:WI (Han)] rats and B6C3F1/N mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 590. https://doi.org/10.22427/NTP-TR-590

National Toxicology Program (NTP). 2018. Report on carcinogens monograph on antimony trioxide (CASRN 1309-64-4). Research Triangle Park, NC: National Toxicology Program. RoC Monograph 13. https://doi.org/10.22427/ROC-MGRAPH-13

In this action, the Administrator finds that lead air pollution may reasonably be anticipated to endanger the public health and welfare within the meaning of the Clean Air Act. The Administrator also finds that engine emissions of lead from certain aircraft cause or contribute to the lead air pollution that may reasonably be anticipated to endanger public health and welfare under the Clean Air Act.

National Toxicity Program (NTP). 2012. Monograph on health effects of low-level lead. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list anthracene (CASRN 120-12-7), 2‑bromopropane (CASRN 75-26-3 [corrected as of June 27, 2023]), and dimethyl hydrogen phosphite (CASRN 868-85-9) as known to the state to cause cancer.

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of 2-bromopropane. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/bromopropanes/2-bromopropane/2bp_monograph.pdf

National Toxicology Program (NTP). 1985. NTP technical report on the toxicology and carcinogenesis studies of dimethyl hydrogen phosphite (CASRN 868-85-9) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 287. https://ntp.niehs.nih.gov/go/tr287abs

The Office of Environmental Health Hazard Assessment (OEHHA) is adopting revised cancer inhalation unit risk (IUR) and slope factors for cobalt and water-soluble cobalt compounds for use in the Air Toxics Hot Spots (Hot Spots) program for use in the Air Toxics Hot Spots Program. This revision corrects the cancer inhalation unit risk factors (IURs) for cobalt sulfate heptahydrate and water-soluble cobalt compounds. OEHHA adopted IURs for these compounds in October 2020.

OEHHA is required to develop guidelines for conducting health risk assessments under the Air Toxics Hot Spots Program (Health and Safety Code Section 44360(b)(2)). In response to this requirement, OEHHA develops unit risk factors for carcinogens, such as cobalt sulfate heptahydrate. The cancer IURs are used to estimate lifetime cancer risks associated with inhalation exposure to a carcinogen. While the IURs for cobalt sulfate heptahydrate and water-soluble cobalt compounds have been corrected, the IURs for cobalt metal and insoluble cobalt compounds have not changed.

National Toxicology Program (NTP). 1996. NTP technical report on the toxicology and carcinogenesis studies of nickel subsulfide (CASRN 12035-72-2) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 453. https://ntp.niehs.nih.gov/go/tr453abs

National Toxicology Program (NTP). 1998a. NTP technical report on the toxicology and carcinogenesis Studies of cobalt sulfate heptahydrate (CASRN 10026-24-1) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 471. https://ntp.niehs.nih.gov/go/tr471abs

NTP. 1998b. Cobalt sulfate heptahydrate (10026-24-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7020340

National Toxicology Program (NTP). 2014a. NTP technical report on the toxicology studies of cobalt metal (CASRN 7440-48-4) in F344/N rats and B6C3F1/N mice and the toxicology and carcinogenesis studies of cobalt metal in F344/NTac rats and B6C3F1/N mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 581. https://ntp.niehs.nih.gov/go/tr581abs

NTP. 2014b. Cobalt (7440-48-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). DOI: https://doi.org/10.22427/NTP-DATA-DTXSID1031040

NTP (National Toxicology Program). 2016. Cobalt. Report on carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cobalt.pdf

The Environmental Protection Agency (EPA) is finalizing reporting and recordkeeping requirements for asbestos under the Toxic Substances Control Act (TSCA). EPA is requiring certain persons who manufactured (including imported) or processed asbestos and asbestos-containing articles, including as an impurity, in the four years prior to the date of publication of this final rule to electronically report certain exposure-related information. This action results in a one-time reporting requirement. EPA and other Federal agencies will use reported information in considering potential future actions, including risk evaluation and risk management activities. This final rule is effective August 24, 2023.

NTP (National Toxicology Program). 2021. Asbestos. Report on carcinogens, fifteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/asbestos.pdf.

At the December 14 meeting of the Carcinogen Identification Committee (CIC), the CIC declined to list Bisphenol A as a carcinogen under Proposition 65 by a vote of 5 (yes) to 6 (no). The CIC voted 10 — 0, with one abstention, to affirm the update to the Section 27000 list recommended in the staff report.

National Toxicology Program (NTP). 1982. Carcinogenesis bioassay of bisphenol A (CASRN 80-05-7) in F344 rats and B6C3F1 mice (feed study). Research Triangle Park, NC: National Toxicology Program. Technical Report 215. https://ntp.niehs.nih.gov/go/tr215abs

National Toxicology Program (NTP). 1995. Genetic toxicity evaluation of bisphenol A (CASRN 80-05-7) in micronucleus study A24930 in F344 rats. Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).  https://cebs.niehs.nih.gov/cebs/study/002-01728-0005-0000-5

National Toxicology Program (NTP). 1999a. Historical B6C3F1 mice 1984-1994 19 studies oral feed route. https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/nih-07_1999/m_hcrpt_rte19991223.rpt

National Toxicology Program (NTP). 1999b. Historical F344 rats 1984-1994 19 studies oral feed route.  https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/nih-07_1999/r_hcrpt_rte19991223.rpt

National Toxicology Program (NTP). 2008. NTP technical report on the toxicology and carcinogenesis study of genistein (CASRN 446-72-0) in Sprague Dawley rats (feed study). Research Triangle Park, NC: National Toxicology Program. Technical Report 545. https://ntp.niehs.nih.gov/go/tr545abs

National Toxicology Program (NTP). 2010. NTP technical report on the toxicology and carcinogenesis study of ethinyl estradiol (CASRN 57-63-6) in Sprague-Dawley rats (feed study).  Research Triangle Park, NC: National Toxicology Program. Technical Report 548. https://ntp.niehs.nih.gov/go/tr548abs

National Toxicology Program (NTP). 2015. Handbook for preparing report on carcinogens monographs. Office of the Report on Carcinogens, National Institute of Environmental Health Sciences. https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/handbook/roc_handbook_508.pdf

National Toxicology Program (NTP). 2016. standard search strings for literature database searches: appendix to the draft handbook for preparing report on carcinogens monographs: April 1, 2016. Office of the Report on Carcinogens, National Institute of Environmental Health Sciences. https://ntp.niehs.nih.gov/sites/default/files/2023-08/Standard_Search_Strings_for_Literature_Database_Searches_for_Preparing_Report_on_Carcinogens_Monographs_2023_final_508.pdf

National Toxicology Program (NTP). 2018. NTP research report on the CLARITY-BPA core study: A perinatal and chronic extended-dose-range study of bisphenol A in rats. NTP RR 9. Research Triangle Park, NC. National Toxicology Program (9): 1-221. https://doi.org/10.22427/NTP-RR-9

National Toxicology Program (NTP). 2021. NTP research report on the consortium linking academic and regulatory insights on bisphenol A toxicity (CLARITY-BPA): a compendium of published findings. Research Triangle Park, NC: National Toxicology Program. Research Report 18. https://doi.org/10.22427/NTP-RR-18

National Toxicology Program (NTP). 2021b. NTP historical controls report all routes and vehicles Harlan Sprague-Dawley rats December 2020.  https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2020/r_hcrpt_allrte20201200.pdf

The Office of Environmental Health Hazard Assessment is adopting new Reference Exposure Levels for 1-Bromopropane for use in the Air Toxics Hot Spots Program. Reference Exposure Levels are airborne concentrations of a chemical that are not anticipated to result in adverse noncancer health effects for specified exposure durations in the general population, including sensitive subpopulations.

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of 1-bromopropane. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/bromopropanes/1-bromopropane/1bp_monograph.pdf

NTP. 1-Bromopropane (106-94-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). DOI: https://doi.org/10.22427/NTP-DATA-DTXSID6021874

National Toxicology Program (NTP). 2011. NTP technical report on the toxicology and carcinogenesis studies of 1-bromopropane in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 564. https://ntp.niehs.nih.gov/go/tr564abs

The National Institute for Occupational Safety and Health (NIOSH) of the Centers for Disease Control and Prevention (CDC), in the Department of Health and Human Services (HHS), announces the following final documents are available in the docket and on the NIOSH website: Procedures for Developing the NIOSH List of Hazardous Drugs in Healthcare Settings and Managing Hazardous Drug Exposures: Information for Healthcare Settings.

National Toxicology Program (NTP). 2019. NTP monograph on the systematic review of occupational exposure to cancer chemotherapy agents and adverse health outcomes. Research Triangle Park, NC: National Toxicology Program. NTP Monograph 05. https://doi.org/10.22427/NTP-MGRAPH-5

NTP (National Toxicology Program). 2021. Report on carcinogens, fifteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc15

Effective April 21, 2023, the Office of Environmental Health Hazard Assessment (OEHHA) is adding 1,1,1-trichloroethane (CAS Registry Number 71-55-6) and leucomalachite green (CAS Registry Number 129-73-7) to the list of chemicals known to the State of California to cause cancer for purposes of Proposition 651. The listing of these chemicals is pursuant to the “Labor Code” listing mechanism2. The warning requirement for significant exposures to these chemicals will take effect on April 21, 2024.

National Toxicology Program (NTP). 1977. Bioassay of 1,1,1-trichloroethane for possible carcinogenicity. Natl Cancer Inst Carcinog Tech Rep Ser. 3:1–77.  https://ntp.niehs.nih.gov/go/tr003abs

National Toxicology Program (NTP). 1996. NTP renal toxicity studies of selected halogenated ethanes administered by gavage to F344/N Rats.  Research Triangle Park, NC: National Toxicology Program. Toxicity Report 45.  https://ntp.niehs.nih.gov/go/tox045abs

National Toxicology Program (NTP). 2000. NTP technical report on the toxicity studies of 1,1,1-trichloroethane (CASRN 71-55-6) administered in microcapsules in feed to F344/N rats and B6C3F1 mice. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 41. https://ntp.niehs.nih.gov/go/tox041abs

National Toxicology Program (NTP). 1978. Bioassay of hydrazobenzene (CASRN 122-66-7) for possible carcinogenicity. Report No. NCI-CG-TR-92. Natl Cancer Inst Carcinog Tech Rep Ser. 92:1–123. https://ntp.niehs.nih.gov/go/tr092abs

National Toxicology Program (NTP).  2016. Hydrazobenzene. Report on Carcinogens, 14th ed. Research Triangle Park (NC), USA: National Toxicology Program, United States Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

National Toxicology Program (NTP). 1989.  NTP technical report on the toxicology and carcinogenesis studies of N-methylolacrylamide (CASRN 924-42-5) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 352.  https://ntp.niehs.nih.gov/go/tr352abs. https://ntp.niehs.nih.gov/go/tr352abs 

National Toxicology Program (NTP). 1986. NTP technical report on the toxicology and carcinogenesis studies of isophorone (CASRN 78-59-1) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 291. https://ntp.niehs.nih.gov/go/tr291abs 

National Center for Toxicological Research (NTCR). 1984. Chronic toxicity and carcinogenicity studies of gentian violet in mice. NCTR technical report for experiment No. 304. Jefferson (AR), USA: National Center for Toxicological Research; pp. 1–52.

National Center for Toxicological Research (NTCR). 1988. Chronic toxicity and carcinogenicity studies of gentian violet in Fischer 344 rats. NCTR technical report for experiment No. 338. Jefferson (AR), USA: National Center for Toxicological Research; pp. 1–57.

National Toxicology Program (NTP). 2005. NTP technical report on the toxicology and carcinogenesis studies of malachite green chloride and leucomalachite green. (CASRNs 569-64-2 and 129-73-7) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 527. https://ntp.niehs.nih.gov/go/tr527abs

National Toxicology Program (NTP). 1992. National Toxicology Program chemical repository database. Research Triangle Park (NC), USA: National Toxicology Program. https://cebs.niehs.nih.gov/

National Toxicology Program (NTP). 1994. NTP technical report on the toxicology and carcinogenesis studies of CI Direct Blue 218 (CASRN 28407-37-6) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 430. https://ntp.niehs.nih.gov/go/tr430abs

National Toxicology Program (NTP). 2016. 3,3′-Dimethoxybenzidine and dyes metabolized to 3,3′-dimethoxybenzidine. Report on carcinogens. 14th ed. Research Triangle Park (NC), USA: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dimethoxybenzidineanddyes.pdf

National Toxicology Program (NTP). 2018. Genetic toxicity evaluation of 3,3′-dihydroxybenzidine in Salmonella/E. coli mutagenicity test or ames test. Study A20942. Research Triangle Park (NC), USA: National Toxicology Program.  https://cebs.niehs.nih.gov/cebs/study/002-01388-0001-0000-3

National Toxicology Program (NTP). (2020). Testing status of CI Direct Blue 218 10249-L. Research Triangle Park (NC): USA. National Toxicology Program. https://doi.org/10.22427/NTP-DATA-DTXSID0025600

The EPA finalizing a program to further reduce air pollution, including ozone and particulate matter (PM), from heavy-duty engines and vehicles across the United States. The requirements in the final rule will lower emissions of NOX and other air pollutants (PM, hydrocarbons (HC), carbon monoxide (CO), and air toxics) beginning no later than model year 2027. This final rule is effective on March 27, 2023.

National Toxicology Program (NTP). 2019. NTP monograph on the systematic review of traffic-related air pollution and hypertensive disorders of pregnancy. Research Triangle Park, NC: National Toxicology Program. NTP Monograph 07. https://doi.org/10.22427/NTP-MGRAPH-7

US EPA published a white paper announcing their intention to accept NAMs as alternatives to four existing Tier 1 assays for the endocrine disruptor screening program, including the rodent uterotrophic assay. These NAMs cover in vitro based estrogen receptor (ER) and androgen receptor (AR) pathway models that were conceptualized (AR) and/or validated (ER and AR) by NICEATM.The EPA also identified NAMs acceptable for priority setting and WoE analysis including QSAR models developed by NICEATM for ER and AR activity that are available in the OPERA tool (https://github.com/NIEHS/OPERA).

Open (Quantitative) Structure-activity/property Relationship App (OPERA). In Silico qualitative structure activity relationship consensus models for ER and AR. https://ntp.niehs.nih.gov/go/opera

ICCVAM (Interagency Coordinating Committee on the Validation of Alternative Methods). (2003). ICCVAM evaluation of in vitro test methods for detecting potential endocrine disruptors: Estrogen receptor and androgen receptor binding and transcriptional activation assays. (NIH Publication No. 03-4503). RTP, NC. https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf

ICCVAM (Interagency Coordinating Committee on the Validation of Alternative Methods). (2018). A strategic roadmap for establishing new approaches to evaluate the safety of chemicals and medical products in the United States. http://dx.doi.org/10.22427/NTP-ICCVAM-ROADMAP2018

In accordance with the World Trade Center (WTC) Health Program’s regulations, which establish procedures for adding a new condition to the list of covered health conditions, this final rule adds malignant neoplasms of corpus uteri and uterus, part unspecified (uterine cancer) to the List of WTC-Related Health Conditions. This rule is effective on January 18, 2023.

NTP (National Toxicology Program). 2021. Report on carcinogens, fifteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.  https://ntp.niehs.nih.gov/go/roc15

On December 30, 2022, the California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) has adopted and published Public Health Goals (PHGs) for the five regulated haloacetic acids (HAAs) found in drinking water as a result of disinfection methods: monochloroacetic acid (MCA), dichloroacetic acid (DCA), trichloroacetic acid (TCA), monobromoacetic acid (MBA), and dibromoacetic acid (DBA). A PHG is the level of a drinking water contaminant at which adverse health effects are not expected to occur from a lifetime of exposure. The California Safe Drinking Water Act of 1996 requires OEHHA to develop PHGs based exclusively on public health considerations. PHGs published by OEHHA are considered by the State Water Resources Control Board in setting drinking water standards (Maximum Contaminant Levels, or MCLs) for California.The technical support document presents the scientific information available on the toxicity of the HAAs and the calculation of the PHGs. The PHGs of 0.2 parts per billion (ppb) for DCA, 0.1 ppb for TCA, and 0.03 ppb for DBA are based on carcinogenicity and are set at a level of risk of one additional cancer case per one million persons exposed over a lifetime. The PHGs of 53 ppb for MCA and 25 ppb for MBA are based on noncancer health effects. OEHHA also presents health-protective drinking water concentrations for noncancer health effects for DCA, TCA, and DBA.The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has adopted and published Public Health Goals (PHGs) for the five regulated haloacetic acids (HAAs) found in drinking water as a result of disinfection methods: monochloroacetic acid (MCA), dichloroacetic acid (DCA), trichloroacetic acid (TCA), monobromoacetic acid (MBA), and dibromoacetic acid (DBA).

NTP (1991). Executive summary of safety and toxicity information. Dichloroacetic acid (CASRN 79-43-6); trichloroacetic acid (CASRN 76-03-9). National Toxicology Program (NTP), National Institute of Health, Research Triangle Park, NC. Accessed at: http://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/chem_background/exsumpdf/dcaa_508.pdf

National Toxicology Program (NTP). 1992. NTP technical report on the toxicology and carcinogenesis studies of monochloroacetic acid (CASRN 79-11-8) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 396. https://ntp.niehs.nih.gov/go/tr396abs

National Toxicology Program (NTP). 2007a. NTP technical report on the toxicology and carcinogenesis studies of dibromoacetic acid (CASRN 631-64-1) in F344/N rats and B6C3F1 mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 537. https://ntp.niehs.nih.gov/go/tr537abs

National Toxicology Program (NTP). 2007b. NTP report on the toxicology studies of dichloroacetic acid (CASRN 79-43-6) in genetically modified (FVB Tg.AC hemizygous) mice (dermal and drinking water studies) and carcinogenicity studies of dichloroacetic acid (CASRN 79-43-6) in genetically modified [B6.129-Trp53tm1Brd (N5) haploinsufficient] mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Genetically Modified Model Report 11. https://ntp.niehs.nih.gov/go/gmm11abs

National Toxicology Program (NTP). 2009. NTP technical report on the toxicology and carcinogenesis studies of bromochloroacetic acid (CASRN 5589- 96-8) in F344/N rats and B6C3F1 mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 549. https://ntp.niehs.nih.gov/go/tr549abs

National Toxicology Program (NTP). 2018. Report on carcinogens monograph on haloacetic acids found as water disinfection by-products. Research Triangle Park, NC: National Toxicology Program. RoC Monograph 12. https://doi.org/10.22427/ROC-MGRAPH-12

National Toxicology Program (NTP). 1996. Information profile for NIEHS nominations of chemicals to the National Toxicology Program - dibromoacetic acid. Research Triangle Park, NC, National Toxicology Program, US Department of Health and Human Services. https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/chem_background/exsumpdf/dibromoaceticacid_508.pdf

National Toxicology Program (NTP). 1999. Toxicology data management system. Historical control tumor incidence summary. Oral water studies. National Toxicology Program, US Department of Health and Human Services. https://ntp.niehs.nih.gov/go/historical_controls

National Toxicology Program (NTP). (2009). NTP historical controls report. National Toxicology Program, US Department of Health and Human Services. https://ntp.niehs.nih.gov/go/historical_controls

NTP (National Toxicology Program). 2021. Report on carcinogens, fifteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://doi.org/10.22427/NTP-OTHER-1003

On December 20, 2022, the Office of Administrative Law approved the Office of Environmental Health Hazard Assessment’s proposal to amend Title 27, California Code of Regulations by adopting Section 25506, originally proposed as Section 25505. The new section addresses acrylamide in food formed by cooking or heat processing.The regulation will be effective on April 1, 2023.

National Toxicology Program (NTP). 2012. NTP technical report on the toxicology and carcinogenesis studies of acrylamide (CASRN 79-06-1) in F344/N rats and B6C3F1 mice (feed and drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 575. https://ntp.niehs.nih.gov/go/tr575abs

National Toxicology Program (NTP). 2014. NTP technical report on the toxicology and carcinogenesis studies of glycidamide (CASRN 5694-00-8) in F344/N Nctr rats and B6C3F1/Nctr mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 588. https://doi.org/10.22427/NTP-TR-588

The Office of Environmental Health Hazard Assessment (OEHHA) is adopting new cancer inhalation unit risk (IUR) and slope factors for 1-Bromopropane (1-BP) for use in the Air Toxics Hot Spots Program. IURs are used to estimate lifetime cancer risks associated with inhalation exposure to a carcinogen. OEHHA is required to develop guidelines for conducting health risk assessments under the Air Toxics Hot Spots Program (Health and Safety Code Section 44360(b)(2)). In implementing this requirement, OEHHA develops new IURs and revises existing IURs for many air pollutants. The IUR for 1-BP was developed using the most recent guidance, “Air Toxics Hot Spots Program Technical Support Document for Cancer Potency Factors,” finalized by OEHHA in 2009.The values for 1-BP are as follows:Inhalation Unit Risk Factor 3.7 x 10e-6 (µg/m10e+3)10e-1Inhalation Slope Factor 1.3 × 10e-2 (mg/kg-day)10e-1A draft document for the 1-BP IUR was released on May 12, 2021, to solicit public comment and was discussed at a virtual public workshop during the subsequent 45-day public review period. No public comments were received on the document. The document was peer reviewed by the State’s Scientific Review Panel (SRP) on Toxic Air Contaminants in October 2021 before being finalized.

National Toxicology Program (NTP). 2013. Monograph on 1-bromopropane. Report on Carcinogens. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/1bromopropane_508.pdf

National Toxicology Program (NTP). 2012. NTP technical report on the toxicology and carcinogenesis studies of 1-bromopropane (CASRN 106-94-5) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 564. https://ntp.niehs.nih.gov/go/tr564 

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential reproductive and developmental effects of 1-bromopropane. NIH Publication 04-4479. National Toxicology Program-Center for the Evaluation of Risks to Human Reproduction. Online at: https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/bromopropanes/1-bromopropane/1bp_monograph.pdf 

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of tribromomethane (bromoform) (CASRN 75-25-2) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 350. https://ntp.niehs.nih.gov/go/tr350 

National Toxicology Program (NTP). 1987. NTP technical report on the toxicology and carcinogenesis studies of bromodichloromethane (CASRN 75-27-4) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 321. https://ntp.niehs.nih.gov/go/tr321 

National Toxicology Program (NTP). 1982b. Carcinogenesis bioassay of 1,2-dibromo-3-chloropropane (CASRN 96-12-8) in F344 rats and B6C3F1 mice (inhalation study). Research Triangle Park, NC: National Toxicology Program. Technical Report 206. https://ntp.niehs.nih.gov/go/tr206

National Toxicology Program (NTP). 1982a. Carcinogenesis bioassay of 1,2-dibromoethane (CASRN 106-93-4) in F344 rats and B6C3F1 mice (inhalation study). Research Triangle Park, NC: National Toxicology Program. Technical Report 210. https://ntp.niehs.nih.gov/go/tr210 

NTP-CEBS (2011a). NTP technical report on the toxicology and carcinogenesis studies of 1-bromopropane (CASRN 106-94-5) in F344/N rats and B6C3F1 mice (inhalation studies). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program. Accessed December 2022. https://cebs.niehs.nih.gov/cebs/publication/TR-564

NTP-CEBS (2011b). NTP Technical Report on the toxicology and carcinogenesis studies of 1-bromopropane (CASRN 106-94-5) in F344/N rats and B6C3F1 mice (inhalation studies). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program. Accessed December 2022. https://cebs.niehs.nih.gov/cebs/publication/TR-564

On April 1, 2022, the Environmental Protection Agency (EPA) determined that Washington's human health criteria (HHC) for certain pollutants were not protective of Washington's designated uses and were not based on sound scientific rationale and, accordingly, proposed to restore protective HHC for those pollutants in Washington's waters. EPA is finalizing protective and science-based Federal HHC in this final rule to protect Washington's waters, including waters where tribes hold treaty-reserved rights to fish.

Docket No. RIN 2040–AG21

NTP (National Toxicology Program). 2021. Report on Carcinogens, fifteenth edition.; Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://doi.org/10.22427/NTP-OTHER-1003

The U.S. Environmental Protection Agency (EPA) is issuing the Contaminant Candidate List (CCL) which is a list of contaminants in drinking water that are currently not subject to any proposed or promulgated national primary drinking water regulations. In addition, these contaminants are known or anticipated to occur in public water systems and may require regulation under the Safe Drinking Water Act (SDWA). This list is the Fifth Contaminant Candidate List (CCL 5) published by the agency since the SDWA amendments of 1996. CCL 5 includes 66 chemicals, 3 chemical groups (cyanotoxins, disinfection byproducts (DBPs), and per- and polyfluoroalkyl substances (PFAS)), and 12 microbial contaminants.

National Toxicology Program (NTP). Testing status of vanadyl sulfate 08004. Available: https://doi.org/10.22427/NTP-DATA-DTXSID4021428 [accessed December 9, 2022]

National Toxicology Program (NTP). Testing status of sodium metavanadate M940043. Available: https://doi.org/10.22427/NTP-DATA-DTXSID3044336 [accessed December 9, 2022]

The Office of Administrative Law approved the Office of Environmental Health Hazard Assessment’s proposal to amend Title 27, California Code of Regulations by adding new subsection 25607.2(b) to Section 25607.2. This new subsection addresses warning content for exposures to acrylamide in food by providing an additional non-mandatory, safe harbor warning option for businesses that cause significant exposures to acrylamide in foods.The regulation will be effective on January 1, 2023.

National Toxicology Program (NTP). (2005). NTP-CERHR monograph on the potential human reproductive and developmental effects of acrylamide. NIH Publication No. 05-4472. US Department of Health and Human Services, Public Health Service, National Institutes of Health, Bethesda, MD. https://ntp.niehs.nih.gov//sites/default/files/ntp/ohat/acrylamide/acrylamide_monograph.pdf

National Toxicology Program (NTP). 2012 NTP technical report on the toxicology and carcinogenesis studies of acrylamide (CASRN 79-06-1) in F344/N rats and B6C3F1 mice (feed and drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 575. https://ntp.niehs.nih.gov/go/tr575abs

National Toxicology Program (NTP). 2014. NTP technical report on the toxicology and carcinogenesis studies of glycidamide (CASRN 5694-00-8) in F344/N Nctr rats and B6C3F1/Nctr mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 588. https://doi.org/10.22427/NTP-TR-588

National Toxicology Program (NTP). 2015. National Toxicology Program handbook for preparing report on carcinogens monographs. US Department of Health and Human Services. https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/handbook

NTP (National Toxicology Program). 2021. Report on carcinogens, fifteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://doi.org/10.22427/NTP-OTHER-1003

NTP (National Toxicology Program). 2021. Acrylamide. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/acrylamide.pdf

On September 1, 2022, the Office of Administrative Law approved the Office of Environmental Health Hazard Assessment’s proposal to amend Title 27, California Code of Regulations by adopting Sections 25607.48 and 25607.49. These new sections provide safe harbor guidance for businesses that cause exposures to glyphosate from consumer products that require a warning under Proposition 65. The regulations will be effective on January 1, 2023.

National Toxicology Program (NTP): “reasonably anticipated to be a human carcinogen”, NTP, 2021. Report on Carcinogens, Fifteenth Edition.; Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc15

The Office of Environmental Health Hazard Assessment (OEHHA) is adopting new Reference Exposure Levels (RELs) for Chromium, Trivalent (Inorganic Water-Soluble Compounds) (Cr(III)) for use in the Air Toxics Hot Spots Program. RELs are airborne concentrations of a chemical that are not anticipated to result in adverse noncancer health effects for specified exposure durations in the general population, including sensitive subpopulations. The adopted RELs cover different types of exposure to Cr(III) in air: infrequent 1-hour exposures, repeated 8-hour exposures, and continuous long-term exposure.

National Toxicology Program (NTP). 1996a. NTP technical report on the toxicology and carcinogenesis studies of nickel oxide (CASRN 1313-99-1) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 451. https://ntp.niehs.nih.gov/go/tr451abs

National Toxicology Program (NTP). 1996b. NTP technical report on the toxicology and carcinogenesis studies of nickel sulfate hexahydrate (CASRN 10101-97-0) in F344/N rats and B6C3F1 mice (inhalation studies) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 454. https://ntp.niehs.nih.gov/go/tr454abs

National Toxicology Program (NTP). 2008. NTP technical report on the toxicology and carcinogenesis studies of chromium picolinate monohydrate (CASRN. 27882-76-4) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 556. https://ntp.niehs.nih.gov/go/tr556abs

The Office of Environmental Health Hazard Assessment (OEHHA) is proposing to adopt a Proposition 65 No Significant Risk Level (NSRL) for antimony trioxide by amending Title 27, California Code of Regulations, section 25705(b). The proposed NSRL for antimony trioxide is 0.13 micrograms per day.

National Toxicology Program (NTP). 2017 NTP Technical report on the toxicology and carcinogenesis studies of antimony trioxide (CASRN 1309-64-4) in Wistar Han [Crl:WI (Han)] rats and B6C3F1/N mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 590. https://doi.org/10.22427/NTP-TR-590

National Toxicology Program (NTP). 2018. Report on carcinogens monograph on antimony trioxide (CASRN 1309-64-4). Research Triangle Park, NC: National Toxicology Program. RoC Monograph 13. https://doi.org/10.22427/ROC-MGRAPH-13

On August 4, 2022, the Office of Administrative Law approved amendments to Title 27, California Code of Regulations by adopting Sections 25697.38 through 24607.47 into Title 27 of the California Code of Regulations. The new sections address exposures to listed cannabis (marijuana) smoke and Delta-9-THC.

National Toxicology Program (NTP). 1996. NTP technical report on the toxicology and carcinogenesis studies of of 1-trans-delta 9-tetrahydrocannabinol (CASRN 1972-08-3) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 446. https://ntp.niehs.nih.gov/go/tr446abs

On September 5, 2000, in response to a petition filed under the Emergency Planning and Community Right-to-Know Act (EPCRA), EPA issued a proposed rule to add a diisononyl phthalate (DINP) category to the list of toxic chemicals subject to the reporting requirements under EPCRA and the Pollution Prevention Act (PPA). EPA proposed to add this chemical category to the EPCRA toxic chemical list based on its preliminary conclusion that this category met the EPCRA toxicity criterion. EPA has updated its hazard assessment for DINP and is proposing to add DINP as a category defined to include branched alkyl di-esters of 1,2 benzenedicarboxylic acid in which alkyl ester moieties contain a total of nine carbons. The updated hazard assessment demonstrates that the proposed DINP category meets the EPCRA toxicity criterion because the members of the category can reasonably be anticipated to cause cancer and serious or irreversible chronic health effects in humans; specifically, developmental, kidney, and liver toxicity. EPA is proposing to add the DINP category to the toxic chemical list on this basis and is requesting comment on the updated DINP hazard assessment and associated updated economic analysis.

NTP (National Toxicology Program). 2016. Di(2-ethylhexyl) Phthalate. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/diethylhexylphthalate.pdf

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-isononyl phthalate (DINP). Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dinp/dinp_monograph_final.pdf

OSHA is considering rulemaking to revise its standards for occupational exposure to lead based on medical findings since the issuance of OSHA’s lead standards that adverse health effects in adults can occur at Blood Lead Levels (BLLs) lower than the medical removal level (≥60 mg/dL in general industry, ≥50 mg/dL in construction) and lower than the level required under current standards for an employee to return to their former job status (<40 mg/dL).1 The agency is seeking input on reducing the current BLL triggers in the medical surveillance and medical removal protection provisions of the general industry and construction standards for lead. The agency is also seeking input about how current ancillary provisions in the lead standards can be modified to reduce worker BLLs.

National Toxicology Program (NTP). (2012). NTP monograph on health effects of low-level lead. Retrieved from: https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf. Accessed on November 10, 2020

The Office of Environmental Health Hazard Assessment (OEHHA) has adopted an NSRL of 3.7 micrograms per day for exposures to 1,3-dichloropropene by the oral and inhalation routes.

National Toxicology Program (NTP). 1985. NTP technical report on the toxicology and carcinogenesis studies of telone II (technical-grade 1,3-dichloropropene (CASRN 542-75-6) containing 1.0% epichlorohydrin as a stabilizer) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 269.
https://ntp.niehs.nih.gov/go/tr269abs

The Food and Drug Administration (FDA) is announcing the availability of a draft guidance for industry entitled "Action Levels for Lead in Juice: Guidance for Industry." The draft guidance, when finalized, would establish action levels of 10 parts per billion (ppb) for lead in single-strength (ready-to-drink) apple juice and 20 ppb for lead in all other single-strength juice types, including juice blends that contain apple juice.

National Toxicity Program (NTP). 2012. NTP monograph on health effects of low-level lead. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf

The Consumer Product Safety Commission (Commission or CPSC) is announcing the availability of a document titled, \"Final Guidance for Industry and Test Method Developers: CPSC Staff Evaluation of Alternative Test Methods and Integrated Testing Approaches and Data Generated from Such Methods to Support FHSA Labeling Requirements.'' The final guidance will be available at: https://www.regulations.gov under docket number, CPSC-2021-0006, under “Supporting and Related Material\".

ICCVAM - Validation and regulatory acceptance of toxicological test methods. March 1997. https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/about_docs/validate.pdf

ICCVAM - ICCVAM guidelines for the nomination and submission of new, revised, and alternative test methods. September 2003. https://ntp.niehs.nih.gov/sites/default/files/iccvam/suppdocs/subguidelines/sd_subg034508.pdf

ICCVAM - Appendix D: ICCVAM validation and regulatory acceptance criteria. https://ntp.niehs.nih.gov/sites/default/files/iccvam/suppdocs/subguidelines/sg034508/sgappd.pdf

The Office of Environmental Health Hazard Assessment (OEHHA) is recommending that the State Water Resources Control Board (Water Board) establish the notification level (NL) for perfluorohexane sulfonic acid (PFHxS) at 2 parts per trillion, or the lowest level at which it can be reliably detected in drinking water using currently available and appropriate technologies. This recommendation is based on OEHHA’s development of a health-protective concentration intended to prevent noncancer effects, including thyroid, liver, and developmental toxicity.

National Toxicology Program (NTP). (2019). NTP technical report on the toxicity studies of perfluoroalkyl sulfonates (perfluorobutane sulfonic acid, perfluorohexane sulfonate potassium salt, and perfluorooctane sulfonic acid) administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 96. https://doi.org/10.22427/NTP-TOX-96

Effective February 25, 2022, for purposes of Proposition 65, the Office of Environmental Health Hazard Assessment (OEHHA) is adding perfluorooctanoic acid (PFOA) (CASRN 335-67-1) to the list of chemicals known to the State of California to cause cancer.The listing of perfluorooctanoic acid (PFOA) is based on its formal identification by the National Toxicology Program (NTP), an authoritative body for purposes of Proposition 65, that the chemical causes cancer. The criteria used by OEHHA for the listing of chemicals under the “authoritative bodies” mechanism can be found in Title 27, Cal. Code of Regs., section 25306.The basis for the listing was described in a public notice published in the March 19, 2021, issue of the California Regulatory Notice Register (Register 2021, No. 12-Z). The title of the notice was “Notice of Intent to List Chemical by the Authoritative Bodies Mechanism: Perfluorooctanoic Acid.” The publication of the notice initiated a 45-day public comment period. OEHHA received five sets of comments during the comment period.

National Toxicology Program (NTP 2011). Specifications for the conduct of studies to evaluate the toxic and carcinogenic potential of chemical, biological and physical agents in laboratory animals for the National Toxicology Program (NTP). January 2011. https://ntp.niehs.nih.gov/ntp/test_info/finalntp_toxcarspecsjan2011.pdf

National Toxicology Program (NTP 2019a). NTP historical controls report, all routes and vehicles, Harlan Sprague-Dawley rats. Version April 2019. US Department of Health and Human Services, NTP, Research Triangle Park, NC. Available from: https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2019/r_hcrpt_allrte20190400.pdf

National Toxicology Program (NTP 2019b). NTP historical controls report, all routes and vehicles, Harlan Sprague-Dawley rats. Version November 2019. US Department of Health and Human Services, NTP, Research Triangle Park, NC. Available from: https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2019/r_hcrpt_allrte20191100.pdf

National Toxicology Program (NTP 2020). NTP technical report on the toxicology and carcinogenesis studies of perfluorooctanoic acid (CASRN 335-67-1) administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats. Technical Report Series No. 598. US Department of Health and Human Services, NTP, Research Triangle Park, NC.  https://doi.org/10.22427/NTP-TR-598

The U.S. Environmental Protection Agency (EPA) is amending the list of hazardous air pollutants (HAP) under Clean Air Act (CAA) to add 1-bromopropane (1-BP) in response to public petitions previously granted by the EPA. This action amends the list of hazardous air pollutants initially listed under the CAA.

NTP (National Toxicology Program). 2014. Bromopropane. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/bromopropane.pdf

On June 16, 2021, the U.S. Environmental Protection Agency (EPA) published the agency's decision to delay the effective and compliance dates of the National Primary Drinking Water Regulations: Lead and Copper Rule Revisions (LCRR), published on January 15, 2021, to allow time for EPA to review the rule in accordance with Presidential directives issued on January 20, 2021, to the heads of Federal agencies to review certain regulations, and conduct important consultations with affected parties. EPA has completed its review. The agency's review included a series of virtual public engagements to hear directly from a diverse set of stakeholders. This document describes the comments conveyed by stakeholders, EPA's decision to proceed with a proposed rule that would revise certain key sections of the LCRR while allowing the rule to take effect, and other non-regulatory actions that EPA and other Federal agencies can take to reduce exposure to lead in drinking water.

National Toxicity Program (NTP). 2012. Monograph on health effects of low-level Lead. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf

In response to a petition filed under the Emergency Planning and Community Right-to-Know Act (EPCRA), EPA is proposing to add 12 chemicals to the list of toxic chemicals subject to the reporting requirements under EPCRA and the Pollution Prevention Act (PPA). EPA believes that each of the 12 chemicals meets the EPCRA criteria. In addition, based on the available bioaccumulation and persistence data, EPA believes that one chemical should be classified as a persistent, bioaccumulative, and toxic (PBT) chemical and designated as a chemical of special concern with a 100-pound reporting threshold.

National Toxicology Program (NTP). 2005. 1,3-Dichloro-2-propanol (CASRN 96–23–1). Review of toxicological literature. Prepared by Integrated Laboratory Systems, Inc., Research Triangle Park, North Carolina, for the National Toxicology Program, National Institute of Environmental Health Sciences.  https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dichloropropanol_508.pdf

National Toxicology Program (NTP). 1992. Final report on the reproductive toxicity of formamide (FORM) (CASRN 75–12–7) in CD–1 Swiss mice: Volume 1 NTIS Technical Report 109213(327). https://ntrl.ntis.gov/NTRL/dashboard/searchResults/titleDetail/PB93109213.xhtml

National Toxicology Program (NTP). 1992. Final report on the reproductive toxicity of formamide (FORM) (CASRN 75–12–7) CD–1 (trade name) Swiss mice: Volume 2. Laboratory supplement. NTIS Technical Report 109221(249).  https://ntrl.ntis.gov/NTRL/dashboard/searchResults/titleDetail/PB93109221.xhtml

National Toxicology Program (NTP). 1998. Final report on the developmental toxicity of formamide (CASRN 75–12–7) administered by gavage to Sprague-Dawley CD rats on gestational days 6–19. NTIS Technical Report 139701(106).  https://ntrl.ntis.gov/NTRL/dashboard/searchResults/titleDetail/PB99139701.xhtml

National Toxicology Program (NTP). 2001. Developmental toxicity evaluation of formamide (CASRN 75– 12–7) administered by gavage to New Zealand white rabbits on gestational days 6 through 29. NTIS Technical Report 104060(460) https://ntrl.ntis.gov/NTRL/dashboard/searchResults/titleDetail/PB2001104060.xhtml

National Toxicology Program (NTP). 1991. NTP technical report on the toxicology and carcinogenesis studies of tris(2- chloroethyl) phosphate (CASRN 115– 96–8) in F344/N rats and B6C3F1 mice (gavage studies). National Toxicology Program Technical Report Series 391: 1– 233. https://ntp.niehs.nih.gov/go/tr391abs

National Toxicology Program (NTP). 1991. Final report on the reproductive toxicity of tris(2- chloroethyl)phosphate reproduction and fertility assessment in Swiss CD–1 mice when administered via gavage. NTIS Technical Report 129170(253).   https://ntrl.ntis.gov/NTRL/dashboard/searchResults/titleDetail/PB92129170.xhtml

Morrissey, R. E., B.A. Schwetz, J.C. Lamb, M.D. Ross, J.L. Teague, and R.W. Morris. 1988. Evaluation of rodent sperm vaginal cytology and reproductive organ weight data from National Toxicology Program 13-week studies. Fundam. Appl. Toxicol. 11(2): 343–358.  https://doi.org/10.1016/0272-0590(88)90159-5

The Food and Drug Administration (FDA or we) is responding to objections and a public hearing request that we received from Combe Inc., on the final rule entitled \"Termination of Listing of Color Additives Exempt From Certification; Lead Acetate,\" which published on October 31, 2018. The final rule amended the color additive regulations to no longer provide for the safe use of lead acetate in cosmetics intended for coloring hair on the scalp. After reviewing the objections, we have concluded that the objections do not raise issues of material fact that justify a hearing. Therefore, the stay of the effectiveness for the repeal and delisting of the color additive regulation is now lifted, and we are amending the color additive regulations to no longer provide for the safe use of lead acetate in cosmetics intended for coloring hair on the scalp.

National Toxicity Program, 2012. Monograph on health effects of low-level lead. U.S. Department of Health and Human Services. June 2012. https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf

The Food and Drug Administration (FDA, Agency, or we) is announcing the availability of an over-the-counter (OTC) monograph proposed order (order ID OTC000008) entitled “Amending Over-the-Counter (OTC) Monograph M020: Sunscreen Drug Products for OTC Human Use.” FDA is issuing this proposed order to amend and revise the deemed final administrative order concerning nonprescription sunscreen drug products (Deemed Final Order) established by the enactment of the Coronavirus Aid, Relief, and Economic Security Act (CARES Act). This proposed order, if finalized, would replace the Deemed Final Order in its entirety with new conditions under which nonprescription sunscreen drug products would be determined to be generally recognized as safe and effective (GRASE) under the Federal Food, Drug, and Cosmetic Act (FD&C Act). It also sets forth certain characteristics that would establish that a sunscreen drug product is not GRASE.

National Toxicology Program (NTP). 2004. NTP technical report on the toxicology and carcinogenesis studies of triethanolamine (CASRN 102-71-6) in B6C3F1 mice (dermal study). Research Triangle Park, NC: National Toxicology Program. Technical Report 518. https://ntp.niehs.nih.gov/go/tr518abs

National Toxicology Program (NTP). 1999. NTP technical report on the toxicology and carcinogenesis studies of triethanolamine (CASRN 102-71-6) in F344/N rats and B6C3F1 mice (dermal studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 449. https://ntp.niehs.nih.gov/go/tr449abs

National Toxicology Program (NTP). 1992. NTP technical report on the toxicity studies of 2-hydroxy-4- methoxybenzophenone (CASRN 131–57–7) administered topically and in dosed feed to F344/N rats and B6C3F1 mice. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 21. https://ntp.niehs.nih.gov/go/tox021abs

Testing status of 2-hydroxy-4- methoxybenzophenone 10260–S (available at https://doi.org/10.22427/NTP-DATA-DTXSID3022405), accessed March 27, 2018.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) will convene a meeting of the Carcinogen Identification Committee (CIC) for possible listing of perfluorooctane sulfonic acid (PFOS) and its salts and transformation and degradation precursors under the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65)[1]. OEHHA is also opening a 45-day public comment period on the hazard identification document for these chemicals. The public comment period will end on Monday, November 8, 2021. A copy of the document is available on OEHHA’s web site at https://oehha.ca.gov/proposition-65. The document may also be requested from OEHHA’s Proposition 65 Implementation Office by calling (916) 445-6900.

National Toxicology Program (NTP). 2020. NTP technical report on the toxicology and carcinogenesis studies of perfluorooctanoic acid (CASRN 335-67-1) administered in feed to Sprague Dawley (HSD:Sprague Dawley SD) rats. Research Triangle Park, NC: National Toxicology Program. Technical Report 598. https://doi.org/10.22427/NTP-TR-598

National Toxicology Program (NTP). 2019. NTP technical report on the toxicity studies of perfluoroalkyl sulfonates (perfluorobutane sulfonic acid, perfluorohexane sulfonate potassium salt, and perfluorooctane sulfonic acid) administered by gavage to Sprague Dawley (Hsd: Sprague Dawley SD) rats. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 96. https://ntp.niehs.nih.gov/go/tox096abs

National Toxicology Program (NTP). 2015. Handbook for preparing report on carcinogens monographs. Office of the Report on Carcinogens, National Institute of Environmental Health Sciences. https://ntp.niehs.nih.gov/go/rochandbook

The Consumer Product Safety Commission is withdrawing its proposed rule on flammability standards for residential upholstered furniture that published March 4, 2008 in the Federal Register. This rulemaking is no longer active because it has been superseded by the COVID-19 Regulatory Relief and Work From Home Safety Act.

National Toxicology Program; NTP review of halogenated flame retardants. https://ntp.niehs.nih.gov/go/hfr

On July 6, 2021, the Office of Administrative Law approved the amendment to Title 27, California Code of Regulations, section 25705, to add a No Significant Risk Level for the chemical dibromoacetic acid. The regulation will be effective on October 1, 2021. This regulation establishes a No Significant Risk Level of 2.8 micrograms per day for dibromoacetic acid for purposes of Proposition 65.

National Toxicology Program (NTP). 2007. NTP technical report on the toxicology and carcinogenesis studies of dibromoacetic acid (CASRN. 631-64-1) in F344/N rats and B6C3F1 mice (drinking water studies). NTP Technical Report Series No. 537. NIH Publication No. 07-4475. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr537

NTP. Sodium nitrite (7632-00-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2021-05-10. https://cebs.niehs.nih.gov/cebs/publication/TR-495

NTP. Sodium chlorate (7775-09-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2021-05-10. https://cebs.niehs.nih.gov/cebs/publication/TR-517

On July 6, 2021, the Office of Administrative Law approved the amendment to Title 27, California Code of Regulations, section 25705, to add a No Significant Risk Level for the chemical trichloroacetic acid. The regulation will be effective on October 1, 2021. This regulation establishes a No Significant Risk Level of 9.9 micrograms per day for trichloroacetic acid for purposes of Proposition 65

National Toxicology Program (NTP). 2015. NTP technical report on the toxicology and carcinogenesis studies of bromodichloroacetic acid (CASRN 71133-14-7) in F344/N rats and B6C3F1/N mice and toxicology and carcinogenesis studies of bromodichloroacetic acid in F344/NTac rats and B6C3F1/N mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 583. NTP Technical Report Series No. 583. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://doi.org/10.22427/NTP-TR-583

National Toxicology Program (NTP). 1999. Historical controls. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/data/controls

On June 24, 2021, the Office of Administrative Law approved the amendment to Title 27, California Code of Regulations, section 25705, to add a No Significant Risk Level for the chemical dichloroacetic acid. The regulation will be effective on October 1, 2021. This regulation establishes a No Significant Risk Level of 17 micrograms per day for dichloroacetic acid for purposes of Proposition 65.

National Toxicology Program (NTP). 2015. NTP technical report on the toxicology and carcinogenesis studies of bromodichloroacetic acid (CASRN 71133-14-7) in F344/N rats and B6C3F1/N mice and toxicology and carcinogenesis studies of bromodichloroacetic acid in F344/NTac rats and B6C3F1/N mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 583. https://doi.org/10.22427/NTP-TR-583

National Toxicology Program (NTP). 1999. Historical controls. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/data/controls

The Food and Drug Administration (FDA or we) is amending the color additive regulations to provide for the safe use of an aqueous extract of butterfly pea flower (Clitoria ternatea) as a color additive in various food categories at levels consistent with good manufacturing practice. We are taking this action in response to a color additive petition (CAP) submitted by Exponent, Inc., on behalf of Sensient Colors, LLC (Sensient).

National Toxicology Program (NTP). 1992. NTP technical report on the toxicology and carcinogenesis studies of quercetin (CASRN 117–39–5) in F344 rats (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 409. https://ntp.niehs.nih.gov/go/tr409abs

The Agency for Toxic Substances and Disease Registry (ATSDR), within the Department of Health and Human Services (HHS) announces the availability of the Toxicological Profile for Perfluoroalkyls published May 05, 2021.

National Toxicology Program (NTP). 2016. Report on Carcinogens, fourteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc14

National Toxicology Program (NTP). 2016. Monograph on immunotoxicity associated with exposure to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/go/749926

A state report released today finds that consumption of synthetic food dyes can result in hyperactivity and other neurobehavioral problems in some children, and that children vary in their sensitivity to synthetic food dyes.The report by the California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) also finds that current federal levels for safe intake of synthetic food dyes may not sufficiently protect children’s behavioral health. The levels were established by the US Food and Drug Administration decades ago and do not reflect newer research.The percentage of American children and adolescents diagnosed with Attention Deficit/Hyperactivity Disorder (ADHD) has increased from an estimated 6.1% to 10.2% during the last 20 years. Concerns about increasing rates of ADHD and other behavioral disorders prompted the California Legislature to ask OEHHA to conduct the food dye assessment.Evidence shows that synthetic food dyes are associated with adverse neurobehavioral outcomes in some children, said OEHHA Director Dr. Lauren Zeise. With increasing numbers of U.S. children diagnosed with behavioral disorders, this assessment can inform efforts to protect children from exposures that may exacerbate behavioral problems.The report is the product of a two-year, multifaceted evaluation of seven synthetic food dyes that have been approved by the FDA. OEHHA extensively reviewed existing studies of the effects of these dyes on both humans and laboratory animals.

NTP Office of Health Assessment and Translation. 2019. OHAT systematic review. https://ntp.niehs.nih.gov/go/ohathandbook

National Toxicology Program (NTP). 1993. NTP technical report on the toxicity studies of a chemical mixture of 25 groundwater contaminants administered in drinking water to F344/N rats and B6C3F1 mice. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 35. https://ntp.niehs.nih.gov/go/tox035abs

The U.S. Environmental Protection Agency (EPA or Agency) is announcing final regulatory determinations for eight of the 109 contaminants listed on the Fourth Contaminant Candidate List. Specifically, the Agency is making final determinations to regulate perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) and to not regulate 1,1-dichloroethane, acetochlor, methyl bromide (bromomethane), metolachlor, nitrobenzene, and RDX. The Safe Drinking Water Act (SDWA), as amended in 1996, requires EPA to make regulatory determinations every five years on at least five unregulated contaminants. A regulatory determination is a decision about whether or not to begin the process to propose and promulgate a national primary drinking water regulation for an unregulated contaminant.

National Toxicology Program (NTP). 1983. Report on the subchronic toxicity via gavage of nitrobenzene (C60082) in Fischer 344 rats and B6C3F1 mice [unpublished]. National Toxicology Program, prepared by the EG&G Mason Research Institute, Worcester, MA, for the National Toxicology Program, National Institute of Environmental Health Services, Public Health Service, U.S. Department of Health and Human Services, Research Triangle Park, NC; MRI–NTP 08–83–19 (as cited in USEPA, 2009).

National Toxicology Program (NTP). 1992. Toxicology and carcinogenesis studies of methyl bromide (CASRN 74-83-9) in B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 385. https://ntp.niehs.nih.gov/go/tr385abs

National Toxicology Program (NTP). 2020. Technical report on the toxicology and carcinogenesis studies of perfluorooctanoic acid (CASRN 335-67-1) administered in feed to Sprague Dawley (Hsd: Sprague Dawley SD) rats. Research Triangle Park, NC: National Toxicology Program. Technical Report 598. https://doi.org/10.22427/NTP-TR-598 

Reducing childhood lead exposure is a priority for the Environmental Protection Agency (EPA). As part of EPA's efforts to reduce childhood lead exposure, and in coordination with the President's Task Force on Environmental Health Risks and Safety Risks to Children, EPA reevaluated the 2001 dust-lead clearance levels (DLCL). Clearance levels indicate the amount of lead in dust on a surface following the completion of an abatement activity. Surface dust is collected via dust wipe samples that are sent to a laboratory for analysis to determine whether clearance has been achieved. The post-abatement dust-lead levels are evaluated against, and must be below, the applicable clearance levels. The DLCL have not changed since they were issued in 2001. EPA is finalizing its proposal to lower the DLCL from 40 micrograms of per square foot (µg/ft\2\) to 10 µg/ft\2\ for floors, and from 250 µg/ft\2\ to 100 µg/ft\2\ for window sills.

National Toxicity Program (NTP). 2012. Monograph on health effects of low-level lead. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf

Effective December 18, 2020, the Office of Environmental Health Hazard Assessment (OEHHA) is adding the developmental endpoint to the existing reproductive toxicity (female endpoint) listing of bisphenol A (BPA) (CAS RN. 80-05-7) on the Proposition 65 list of chemicals known to the State to cause cancer or reproductive toxicity. Bisphenol A was added to the Proposition 65 list as known to cause reproductive toxicity for the female reproductive toxicity endpoint, effective May 15, 2015. The listing now includes an additional endpoint, developmental toxicity.The chemical was delisted effective April 19, 2013, based on a trial court injunction prohibiting the listing of BPA for the developmental endpoint pending final resolution of the case - American Chemistry Council [ACC] v Office of Environmental Health Hazard Assessment, et al., Sacramento County case number 34-2013-00140720. That court eventually denied the ACC’s challenge to the listing and the ACC appealed. The Court of Appeal kept an injunction in place pending their resolution of the case. On October 19, 2020 the Third District Court of Appeal entered a judgment affirming the trial court decision and an order dissolving the injunction. The time to seek California Supreme Court review has passed, so the Court of Appeal decision is final. Therefore, OEHHA is reinstating the developmental toxicity endpoint for the listing of BPA as causing reproductive toxicity at this time, on the same basis as the original listing for that endpoint https://oehha.ca.gov/proposition-65/crnr/notice-intent-list-bisphenol.

National Toxicology Program (NTP). 2008. Monograph on the potential human reproductive and developmental effects of bisphenol A. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/bisphenol/bisphenol.pdf

On December 2, 2020, the Office of Administrative Law approved the amendment of Title 27, California Code of Regulations, section 25705, which adopted a Proposition 65 No Significant Risk Level (NSRL) of 23 micrograms per day for the chemical p-chloro-α,α,α-trifluorotoluene (PCBTF). The regulation will be effective on April 1, 2021.

National Toxicology Program (NTP). 2018. NTP technical report on the toxicology and carcinogenesis studies of p-chloro-α,α,α- trifluorotoluene in Sprague Dawley rats (Hsd:Sprague Dawley SD) and B6C3F1/N mice (inhalation studies). NTP Technical Report Series No. 594. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://doi.org/10.22427/NTP-TR-594 

National Toxicology Program (NTP). 2015. Handbook for preparing report on carcinogens monographs. Office of the Report on Carcinogens, National Institute of Environmental Health Sciences. https://ntp.niehs.nih.gov/go/rochandbook

The Environmental Protection Agency (EPA) is finalizing changes to existing regulations to protect the public from lead in plumbing materials used in public water systems or residential or nonresidential facilities providing water for human consumption. The changes in this rule codify aspects of the Reduction of Lead in Drinking Water Act of 2011 (RLDWA) and the Community Fire Safety Act of 2013 (CFSA).

National Toxicity Program (NTP). 2012. Monograph on health effects of low-level lead. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf

The Office of Environmental Health Hazard Assessment (OEHHA) is adopting new Reference Exposure Levels (RELs) for Toluene for use in the Air Toxics Hot Spots Program. RELs are airborne concentrations of a chemical that are not anticipated to result in adverse noncancer health effects for specified exposure durations in the general population, including sensitive subpopulations. The adopted RELs cover different types of exposure to toluene in air: infrequent 1-hour exposures, repeated 8-hour exposures, and continuous long-term exposures.OEHHA is required to develop guidelines for conducting health risk assessments under the Air Toxics Hot Spots Program (Health and Safety Code Section 44360(b)(2)). In response to this statutory requirement, OEHHA develops RELs for many air pollutants, including Toluene. The Toluene RELs were developed using the most recent “Air Toxics Hot Spots Program Technical Support Document for the Derivation of Noncancer Reference Exposure Levels” (OEHHA, 2008). Toluene has been demonstrated to have neurotoxic effects. This chemical will also be added to the list of Toxic Air Contaminants that may disproportionately impact children, pursuant to Health and Safety Code Section 39669.5(b)(1).

National Toxicology Program (NTP) (1990). NTP technical report on the toxicology and carcinogenesis studies of toluene in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 371. https://ntp.niehs.nih.gov/go/tr371abs

The Office of Environmental Health Hazard Assessment (OEHHA) is adopting a new cancer inhalation unit risk (IUR) and slope factor for p-Chloro-a,a,a-Trifluorotoluene for use in the Air Toxics Hot Spots Program. IURs are used to estimate lifetime cancer risks associated with inhalation exposure to a carcinogen. OEHHA is required to develop guidelines for conducting health risk assessments under the Air Toxics Hot Spots Program (Health and Safety Code Section 44360(b)(2)). In implementing this requirement, OEHHA develops new IURs and revises existing IURs for many air pollutants. The IUR for PCBTF was developed using the most recent “Air Toxics Hot Spots Program Technical Support Document for Cancer Potency Factors,” finalized by OEHHA in 2009.

National Toxicology Program (NTP). 1992. NTP technical report on the toxicity studies of p-chloro-a,a,a-trifluorotoluene (CASRN 98-56-6) administered in corn oil and a-cyclodextrin to F344/N rats and B6C3F1 mice in 14-day comparative gavage studies. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 14. https://ntp.niehs.nih.gov/go/tox014abs

National Toxicology Program (NTP). 2009. Chemical information profile for 1-Chloro-4-(trifluoromethyl)-benzene (CASRN 98-56-6); supporting nomination for toxicological evaluation by the National Toxicology Program. National Toxicology Program, National Institute of Environmental Health Sciences, June 2009. https://ntp.niehs.nih.gov/ntp/noms/support_docs/pcbtf060409.pdf

National Toxicology Program (NTP). 2018. NTP technical report on the toxicity studies of p-chloro-a,a,a-trifluorotoluene (CASRN 98-56-6) in Sprague Dawley rats (Hsd:Sprague Dawley SD) and B6C3F1/N mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 594. https://doi.org/10.22427/NTP-TR-594

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is announcing the publication of the updated Public Health Goal (PHG) for 1,2-dibromo-3-chloropropane (DBCP). A PHG is the level of a drinking water contaminant at which adverse health effects are not expected to occur from a lifetime of exposure. The updated Public Health Goal of 0.003 parts per billion (ppb) is based on carcinogenicity and is set at a level of risk of one additional cancer case per one million persons exposed over a 70-year lifetime.

National Toxicology Program (NTP). 1982. NTP technical report on the carcinogenesis bioassay of 1,2-dibromo-3-chloropropane in F344 rats and B6C3F1 mice (inhalation study). Research Triangle Park, NC: National Toxicology Program. Technical Report 206. https://ntp.niehs.nih.gov/go/tr206abs

EPA is proposing corrections to existing regulatory language for the Toxics Release Inventory (TRI) Program. EPA is proposing corrections that will update identifiers, formulas, and names for certain TRI-listed chemicals and updates to the text that identifies which chemicals the 0.1 percent de minimis concentration applies to in order to remedy a cross-reference to a no-longer-accurate Occupational Safety and Health Administration (OSHA) regulatory citation. These proposed corrections maintain previous regulatory actions and do not alter existing reporting requirements or impact compliance burdens or costs.

NTP (National Toxicology Program). 2016. Report on Carcinogens, fourteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc14

The Environmental Protection Agency and the National Highway Traffic Safety Administration, on behalf of the Department of Transportation, are issuing final rules to amend and establish carbon dioxide and fuel economy standards. Specifically, EPA is amending carbon dioxide standards for model years 2021 and later, and NHTSA is amending fuel economy standards for model year 2021 and setting new fuel economy standards for model years 2022-2026. The standards set by this action apply to passenger cars and light trucks, and will continue our nation's progress toward energy independence and carbon dioxide reduction, while recognizing the realities of the marketplace and consumers' interest in purchasing vehicles that meet all of their diverse needs. These final rules represent the second part of the Administration's action related to the August 24, 2018 proposed Safer Affordable Fuel-Efficient (SAFE) Vehicles Rule. These final rules follow the agencies' actions, taken September 19, 2019, to ensure One National Program for automobile fuel economy and carbon dioxide emissions standards, by finalizing regulatory text related to preemption under the Energy Policy and Conservation Act and withdrawing a waiver previously provided to California under the Clean Air Act.

NTP (National Toxicology Program). 2016. Report on Carcinogens, fourteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc14

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is the lead agency for the implementation of the Safe Drinking Water and Toxic Enforcement Act of 1986. OEHHA received a request for a Safe Use Determination (SUD) for exposures to bisphenol A (BPA) from certain polycarbonate eyewear products manufactured, distributed, or sold by The Vision Council (TVC) member companies.Based on OEHHA’s screening-level analysis of the information and data provided by TVC, the upper-end estimate of dermal exposure to BPA for users of certain polycarbonate eyewear products (prescription glasses and sunglasses, OTC reading glasses, non-prescription sunglasses, and safety glasses) manufactured, distributed, or sold by TVC member companies, with acetonitrile extractable concentrations of BPA as specified above, is 0.53 µg/day. This exposure estimate falls below the \"Maximum Allowable Dose Level (MADL)” for BPA (dermal exposure from solid materials) of 3 µg per day. The MADL is defined as the level of exposure that corresponds to the “no observed effect level” divided by 1000. Thus, exposures to BPA from use of such eyewear products, under the conditions described in OEHHA’s assessment, would not require a Proposition 65 warning.

CERHR (2008). NTP-CERHR monograph on the potential human reproductive and developmental effects of bisphenol A. Research Triangle Park, NC, National Toxicology Program: 395. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/bisphenol/bisphenol.pdf

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is announcing the publication of Public Health Goals (PHGs) for four trihalomethanes (THMs) found in drinking water as a result of disinfection methods: chloroform, bromodichloromethane (BDCM), dibromochloromethane (DBCM), and bromoform. A PHG is the level of a drinking water contaminant at which adverse health effects are not expected to occur from a lifetime of exposure.

National Toxicology Program (NTP). 1985. Toxicology and carcinogenesis studies of chlorodibromomethane (CAS No. 124- 48-1) in F344/N rats and B6C3F1 mice (gavage studies). NTP Technical Report Series No. 282, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr282abs

National Toxicology Program (NTP). 1987. Toxicology and carcinogenesis studies of bromodichloromethane (CAS No. 75-27- 4) in F344/N rats and B6C3F1 mice (gavage studies). NTP Technical Report Series No. 321, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC. 182 pp. https://ntp.niehs.nih.gov/go/tr321abs

National Toxicology Program (NTP). 1988. Chloroform reproduction and fertility assessment in CD-1 mice when administered by gavage. Report by Environmental Health Research and Testing, Inc., Lexington, Kentucky, to National Toxicology Program, NTP-89-018. NTIS PB89-148639. National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/racb87045abs

National Toxicology Program (NTP). 1989a. Toxicology and carcinogenesis studies of tribromomethane (bromoform) (CAS No. 75-25-2) in F344/N rats and B6C3F1 mice (gavage studies). NTP Technical Report Series No. 350, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr350abs

National Toxicology Program (NTP). 1989b. Bromoform: reproduction and fertility assessment in Swiss CD-1 mice when administered by gavage. Report no. NTP-89-068. National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/racb87111abs

National Toxicology Program (NTP). 1994. Comparative toxicology studies of corn oil, safflower oil, and tricaprylin (CAS Nos. 8001-30-7, 8001-23-8, and 538-23-8) in male F344/N rats as vehicles for gavage. NTP Technical Report Series No. 426, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr426abs

National Toxicology Program (NTP). 1996. Final report on the short term reproductive and developmental toxicity of chlorodibromomethane (CAS No. 124-48-1) administered in drinking water to Sprague-Dawley rats. Report by R.O.W. Sciences, Inc., Gaithersburg, MD. Pub No. NTIS/PB97-111728. National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/rdgt94003abs

National Toxicology Program (NTP). 1998. Final Report on the short-term reproductive and developmental toxicity of bromodichloromethane (CAS No. 75-27-4) administered in drinking water to Sprague-Dawley rats. Pub no. NTIS/PB99-111262. National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/rdgt94017abs

National Toxicology Program (NTP). 2006. Toxicology and carcinogenesis studies of bromodichloromethane (CAS No. 75-27- 4) in male F344/N rats and female B6C3F1 mice (drinking water studies). National Toxicoly Program Tech Rep Ser 532:1-248. https://ntp.niehs.nih.gov/go/tr532abs

National Toxicology Program (NTP). 2007. Toxicology studies of bromodichloromethane (CAS No. 75-27-4) in genetically modified (FVB Tg.AC Hemizygous) mice (dermal, drinking water, and gavage studies) and carcinogenicity studies of bromodichloromethane in genetically modified [B6.129-Trp53(tm1Brd) (N5) haploinsufficient] mice (drinking water and gavage studies). NTP Genet Modif Model Rep 5:1-227. https://ntp.niehs.nih.gov/go/gmm05abs

National Toxicology Program (NTP). 2016a. Chloroform. Report on Carcinogens, fourteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.  https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chloroform.pdf

National Toxicology Program (NTP). 2016b. Bromodichloromethane. Report on Carcinogens, fourteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/bromodichloromethane.pdf

Effective January 3, 2020, the Office of Environmental Health Hazard Assessment is adding cannabis (marijuana) smoke and Δ9-tetrahydrocannabinol (Δ9-THC) to the list of chemicals known to the state to cause reproductive toxicity (developmental endpoint) for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65)

NTP. 1996. Toxicology and carcinogenesis studies of 1-trans-delta(9)- tetrahydrocannabinol (CAS No. 1972-08-3) in F344 rats and B6C3F1 mice (gavage studies). National Toxicoly Program Tech Rep Ser 446:1-317. https://ntp.niehs.nih.gov/go/tr446abs

On April 23, 2019, the Administrator of the World Trade Center (WTC) Health Program received a petition (Petition 023) to add \"endometrial cancer'' to the List of WTC-Related Health Conditions (List). Upon reviewing the scientific and medical literature, including information provided by the petitioner, the Administrator has determined that the available evidence does not have the potential to provide a basis for a decision on whether to add the major site uterine cancer, including its subtype, endometrial cancer, to the List. The Administrator also finds that insufficient evidence exists to request a recommendation of the WTC Health Program Scientific/Technical Advisory Committee (STAC), to publish a proposed rule, or to publish a determination not to publish a proposed rule.

NTP (National Toxicology Program). 2016. Report on Carcinogens, fourteenth edition.; Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc14

Addressing childhood lead exposure is a priority for EPA. As part of EPA's efforts to reduce childhood lead exposure, EPA evaluated the current dust-lead hazard standards (DLHS) and the definition of lead-based paint (LBP). Based on this evaluation, this final rule revises the DLHS from 40 [micro]g/ft\2\ and 250 [micro]g/ft\2\ to 10 [micro]g/ft\2\ and 100 [micro]g/ft\2\ on floors and window sills, respectively. EPA is also finalizing its proposal to make no change to the definition of LBP because insufficient information exists to support such a change at this time.

National Toxicity Program (NTP). 2012. Monograph on health effects of low-level lead. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list p-chloro-α,α,α-trifluorotoluene (also known as para-chlorobenzotrifluoride, or PCBTF) as known to the state to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986[1]. This action is being proposed under the authoritative bodies listing mechanism.

National Toxicology Program (NTP). 2018. NTP technical report on the toxicology and carcinogenesis studies of p-chloro-α,α,α-trifluorotoluene in Sprague Dawley rats (Hsd:Sprague Dawley SD) and B6C3F1/N mice (inhalation studies). Research Triangle Park, NC. Technical Report 594. https://ntp.niehs.nih.gov/go/tr594abs

Under the Toxic Substances Control Act (TSCA), EPA is promulgating a rule to ensure that any discontinued uses of asbestos cannot re-enter the marketplace without EPA review, closing a loophole in the regulatory regime for asbestos.

NTP (National Toxicology Program). 2016. Report on Carcinogens, fourteenth edition.; Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc14

NTP (National Toxicology Program). Asbestos. 2016. Report on Carcinogens, fourteenth edition.; Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.  https://ntp.niehs.nih.gov/ntp/roc/content/profiles/asbestos.pdf

The Food and Drug Administration (FDA, the Agency, or we) is issuing this final action establishing that certain active ingredients used in nonprescription (also known as over-the-counter (OTC)) consumer antiseptic products intended for use without water (referred to throughout as consumer antiseptic rubs or consumer rubs) are not eligible for evaluation under the OTC Drug Review for use in consumer antiseptic rubs. Drug products containing these ineligible active ingredients will require approval under a new drug application (NDA) or abbreviated new drug application (ANDA) prior to marketing. FDA is issuing this final action after considering the recommendations of the Nonprescription Drugs Advisory Committee (NDAC), public comments on the Agency's notices of proposed rulemaking, and all data and information on OTC consumer antiseptic rub products that have come to the Agency's attention. This final action finalizes the 1994 tentative final monograph (TFM) for OTC consumer antiseptic rub drug products that published in the Federal Register of June 17, 1994 (the 1994 TFM), as amended by the proposed rule published in the Federal Register (FR) of June 30, 2016 (2016 Consumer Antiseptic Rub proposed rule). Effective April 13, 2020.

Docket No. FDA-1975-N-0012

National Toxicology Program (NTP). 2004. NTP technical report on the toxicology and carcinogenesis studies of urethane, ethanol, and urethane/ethanol (urethane, CASRN 51-79-6; ethanol, CASRN 64-17-5) in B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 510. https://ntp.niehs.nih.gov/go/tr510abs

National Toxicology Program (NTP). 1995. NTP technical report on the toxicology and carcinogenesis studies of benzethonium chloride (CASRN 121–54–0) in F344/N rats and B6C3F1 mice (dermal studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 438. https://ntp.niehs.nih.gov/go/tr438abs

National Toxicology Program (NTP). 1988. NTP technical report on the toxicology and carcinogenesis studies of 4-Hexylresorcinol (CASRN 136-77-6) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 330. https://ntp.niehs.nih.gov/go/tr330abs

Docket No. FDA-2016-N-0124 (Formerly Part of Docket No. FDA-1975-N-0012)

National Toxicology Program (NTP). 1999. NTP technical report on the toxicology and carcinogenesis studies of diethanolamine (CASRN 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 478. https://ntp.niehs.nih.gov/go/tr478abs

On February 5, 2019, the Office of Administrative Law approved the amendment of Title 27, California Code of Regulations, section 25705, to add a No Significant Risk Level for the chemical bromodichloroacetic acid. The regulation will be effective on April 1, 2019. This regulation establishes a No Significant Risk Level of 0.95 micrograms per day for bromodichloroacetic acid for purposes of Proposition 65.

National Toxicology Program (NTP). 2015. Toxicology studies of bromodichloroacetic acid (CASRN 71133-14-7) in F344/N rats and B6C3F1/N mice and toxicology and carcinogenesis studies of bromodichloroacetic acid in F344/NTac rats and B6C3F1/N mice (drinking water studies). NTP Technical Report Series No. 583. https://ntp.niehs.nih.gov/go/tr583abs

On February 5, 2019, the Office of Administrative Law approved the amendment of Title 27, California Code of Regulations, section 25705, to add a No Significant Risk Level for the chemical bromochloroacetic acid. The regulation will be effective on April 1, 2019. This regulation establishes a No Significant Risk Level of 0.70 micrograms per day for bromochloroacetic acid for purposes of Proposition 65.

National Toxicology Program (NTP). 2009. NTP technical report on the toxicology and carcinogenesis studies of bromochloroacetic acid (CASRN 5589-96-8) in F344/N rats and B6C3F1 mice (drinking water studies). Technical Report Series No. 549. NIH Publication No. 09-5890. https://ntp.niehs.nih.gov/go/tr549abs

This regulation establishes an exemption from the requirement of a tolerance for residues of chlorate in or on cantaloupe and tomato under the Federal Food, Drug, and Cosmetic Act (FFDCA).

National Toxicology Program (NTP). 2005. NTP technical report on the toxicology and carcinogenesis studies of sodium chlorate (CASRN 7775-09-9) in F344/N rats and B6C3F1 mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 517. https://ntp.niehs.nih.gov/go/tr517abs.

The Food and Drug Administration (FDA, the Agency, or we) is partially granting a petition submitted by the Breast Cancer Fund (now known as the Breast Cancer Prevention Partners), Center for Environmental Health, Center for Food Safety, Center for Science in the Public Interest, Consumers Union, Environmental Defense Fund, Environmental Working Group, Improving Kids’ Environment, Natural Resources Defense Council, WE ACT for Environmental Justice, and Mr. James Huff, by amending the food additive regulations to no longer authorize the use of benzophenone, ethyl acrylate, eugenyl methyl ether, myrcene, pulegone, and pyridine as synthetic flavoring substances for use in food. We are taking this action because, despite FDA’s scientific analysis and determination that these substances do not pose a risk to public health under the conditions of their intended use, the petitioners provided data demonstrating that these additives induce cancer in laboratory animals, and, as a result of this finding in animals, FDA cannot as a matter of law maintain the listing of these synthetic flavoring substances in the food additive regulations. Because of evidence that benzophenone causes cancer in animals, FDA also is amending the food additive regulations to no longer provide for the use of benzophenone as a plasticizer in rubber articles intended for repeated use in contact with food. FDA is denying as moot the portions of the petition proposing that the food additive regulations be amended to no longer authorize the use of styrene as a synthetic flavoring substance because this use has been permanently and completely abandoned. In addition, FDA is declining to act on the petitioners’ request to issue a regulation to prohibit the use of these synthetic flavoring substances in food because that issue is not the proper subject of a food additive petition.

NTP. Ethyl acrylate (140-88-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). https://cebs.niehs.nih.gov/cebs/test_article/140-88-5.

NTP. Benzophenone (119-61-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). https://cebs.niehs.nih.gov/cebs/test_article/119-61-9.

NTP. Methyleugenol (93-15-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). https://cebs.niehs.nih.gov/cebs/test_article/93-15-2.

NTP. beta-Myrcene (123-35-3). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). https://cebs.niehs.nih.gov/cebs/test_article/123-35-3.

NTP. Pulegone (89-82-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). https://cebs.niehs.nih.gov/cebs/test_article/89-82-7.

NTP. Pyridine (110-86-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). https://cebs.niehs.nih.gov/cebs/test_article/110-86-1.

The Office of Environmental Health Hazard Assessment (OEHHA) is adopting a new cancer inhalation unit risk factor (IUR) for tert-butyl acetate (TBAc). IURs are used to estimate lifetime cancer risks associated with inhalation exposure to a carcinogen.

National Toxicology Program (NTP). 1995. NTP technical report on the toxicology and carcinogenesis studies of t-butyl alcohol (CASRN 75-65-0) in F344/N rats and B6C3F1 mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 436. https://ntp.niehs.nih.gov/go/tr436abs

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is announcing the publication of updated Public Health Goals (PHGs) for cis- and trans-1,2-dichloroethylene (cis-/trans-1,2-DCE) in drinking water. A PHG is the level of a drinking water contaminant at which adverse health effects are not expected to occur from a lifetime of exposure. The California Safe Drinking Water Act of 1996 requires OEHHA to develop PHGs based exclusively on public health considerations. PHGs published by OEHHA are considered by the State Water Resources Control Board in setting drinking water standards (Maximum Contaminant Levels, or MCLs) for California.The technical support document, available for download below, presents an update of the cis- and trans-1,2-DCE PHGs. The updated PHGs are 13 parts per billion (ppb) for cis-1,2-DCE based on kidney effects and 50 ppb for trans-1,2-DCE based on immune system effects.

National Toxicology Program (NTP). 2002. NTP technical report on the toxicity studies of trans-1,2-dichloroethylene (CASRN 156-60-5) administered in microcapsules in feed to F344/N rats and B6C3F1 mice. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 55. https://ntp.niehs.nih.gov/go/tox55abs

Effective May 25, 2018, the Office of Environmental Health Hazard Assessment (OEHHA) is adding TRIM® VX to the list of chemicals known to the State of California to cause cancer for purposes of Proposition 65. The listing of TRIM® VX is based on formal identification by the National Toxicology Program (NTP), an authoritative body, that the chemical causes cancer. The criteria used by OEHHA for the listing of chemicals under the “authoritative bodies” mechanism can be found in Title 27, Cal. Code of Regs., section 25306.The documentation supporting OEHHA’s determination that the criteria for administrative listing have been satisfied for TRIM® VX is included in the “Notice of Intent to List: TRIM® VX” posted on OEHHA’s website and published in the January 26, 2018 issue of the California Regulatory Notice Register (Register 2018, No. 4-Z). The publication of the notice initiated a public comment period that closed on February 26, 2018. OEHHA received two public comments on TRIM® VX. The comments and OEHHA’s responses are posted with the Notice of Intent to List.

National Toxicology Program (NTP). 2016. NTP technical report on the toxicology and carcinogenesis studies of TRIM® VX in Wistar Han [Crl:WI (Han)] rats and B6C3F1/N mice (inhalation studies). Technical Report Series No. 591. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr591abs.

Acrylamide is on the Proposition 65 list of chemicals known to the state to cause cancer or reproductive toxicity (such as birth defects and other reproductive harm).Acrylamide is formed in some baked, fried and roasted foods. It is also present in tobacco smoke. Smokers are exposed to particularly high levels of acrylamide.Acrylamide is a carcinogen. It was added to the Proposition 65 list in 1990 because studies showed it produced cancer in laboratory rats and mice. In February 2011, acrylamide was added to the Proposition 65 list as causing reproductive and developmental effects because, in studies of laboratory animals, acrylamide affected the growth of offspring exposed in the womb and caused genetic damage that resulted in the death of mouse and rat embryos.Plant-based foods that are rich in carbohydrates can form acrylamide when baked, fried or roasted – whether they are cooked at home, in restaurants or by commercial food processors and manufacturers. French fries, potato chips, other fried and baked snack foods, coffee, roasted grain-based coffee substitutes, roasted asparagus, canned sweet potatoes and pumpkin, canned black olives, roasted nuts, prune juice, breakfast cereals, crackers, cookies, breads, and toast all may contain varying amounts of acrylamide. Foods that have been boiled or steamed do not contain acrylamide.The U.S. Food and Drug Administration (FDA) and other health and scientific organizations continue to study the health effects of acrylamide in food. The FDA has not advised people at this time to stop eating products that contain acrylamide. The FDA does advise people to quit smoking.

NTP (National Toxicology Program). 2016. Report on Carcinogens, fourteenth edition.; Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc14

National Toxicology Program. (NTP). 2018. Acrylamide.https://www.niehs.nih.gov/health/topics/agents/acrylamide/index.cfm

National Toxicology Program. (NTP). 2013. Fact sheet on acrylamide. https://www.niehs.nih.gov/health/assets/docs_a_e/acrylamide_508.pdf

On May 9, 2018, the Office of Administrative Law approved the amendment of Title 27, California Code of Regulations, section 25705, No Significant Risk Level (NSRL) for the chemical vinylidene chloride. The regulation will be effective on July 1, 2018. This regulation establishes a No Significant Risk Level of 0.88 micrograms per day for vinylidene chloride for purposes of Proposition 65.

National Toxicology Program (NTP, 2015). Toxicology and carcinogenesis studies of vinylidene chloride (CASRN 75-35-4) in F344/N rats and B6C3F1 mice (inhalation studies). NTP Technical Report Series No. 582. U.S. Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr582abs

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is announcing the publication of updated Public Health Goals (PHGs) for nitrate and nitrite in drinking water. A PHG is the level of a drinking water contaminant at which adverse health effects are not expected to occur from a lifetime of exposure. The California Safe Drinking Water Act of 1996 requires OEHHA to develop PHGs based exclusively on public health considerations. PHGs published by OEHHA are considered by the State Water Resources Control Board in setting drinking water standards (Maximum Contaminant Levels, or MCLs) for California.The technical support document, presents an update of the nitrate and nitrite PHGs. A review of the scientific literature published since the development of the original nitrate and nitrite PHGs in 1997 has identified no new information to support changing the current PHGs of 45 parts per million (ppm) for nitrate and 3 ppm for nitrite. Nitrate and nitrite can also be expressed in terms of their concentrations as nitrogen. When expressed as nitrogen, 45 ppm nitrate is equivalent to 10 ppm nitrogen. The PHG of 3 ppm for nitrite is 1 ppm when expressed as nitrogen. The PHGs for nitrate and nitrite expressed as nitrogen have not changed. The combined nitrate/nitrite PHG of 10 ppm (as nitrogen), which accounts for the additive toxicity of nitrate and nitrite, also remains unchanged. It does not replace the individual values, and the maximum contribution from nitrite should not exceed 1 ppm nitrite-nitrogen. These PHGs protect against the occurrence of infant methemoglobinemia, a blood disorder that results in decreased oxygen distribution to tissues, as well as other effects, such as liver toxicity, that have been shown to occur at higher levels of exposure and in the general population.

National Toxicology Program (NTP). 2001. NTP technical report on the toxicology and carcinogenesis studies of sodium nitrite (CASRN 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 495. https://ntp.niehs.nih.gov/go/tr495abs

NTP (National Toxicology Program). 2014. Report on Carcinogens, thirteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

The Office of Environmental Health Hazard Assessment (OEHHA) is adopting revised Reference Exposure Levels (RELs) for Ethylene Glycol mono-n-Butyl Ether (EGBE) (CAS No. 111-76-2) for use in the Air Toxics Hot Spots program. RELs are airborne concentrations of a chemical that are not anticipated to result in adverse noncancer health effects for specified exposure durations in the general population, including sensitive subpopulations. The adopted RELs cover different types of exposure to EGBE in air: infrequent 1-hour exposures, repeated 8-hour exposures, and continuous long-term exposure.

National Toxicology Program (NTP). 2000. NTP technical report on the toxicology and carcinogenesis studies of 2-butoxyethanol (CASRN 111-76-2) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 484. https://ntp.niehs.nih.gov/go/tr484abs

National Toxicology Program Nonneoplastic Lesion Atlas. Nose, epithelium - accumulation, hyaline droplet. available: https://ntp.niehs.nih.gov/atlas/nnl/respiratory-system/nose/Epithelium-AccumulationHyalineDroplet [accessed October 2015]

On April 6, 2018, the Office of Administrative Law approved an amendment of Title 27, California Code of Regulations, section 25705, No Significant Risk Level (NSRL) for the chemical glyphosate. The regulation will be effective on July 1, 2018. This regulation establishes a NSRL of 1100 micrograms per day for glyphosate.

National Toxicology Program (NTP). 2015. Handbook for preparing Report on Carcinogens monographs. Office of the Report on Carcinogens, Division of the NTP, National Institute of Environmental Health Sciences, US Department of Health and Human Services. https://ntp.niehs.nih.gov/go/rochandbook

The National Institute for Occupational Safety and Health (NIOSH) of the Centers for Disease Control and Prevention (CDC) announces the availability for public comment on the drugs proposed for placement on the NIOSH List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings, 2018 (List), as well as the NIOSH Policy and Procedures for Developing the NIOSH List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings.

NTP (National Toxicology Program). 2016. Report on Carcinogens, fourteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

The Food and Drug Administration (FDA, the Agency, or we) is issuing this final rule establishing that certain active ingredients used in nonprescription (also known as over-the-counter or OTC) antiseptic products intended for use by health care professionals in a hospital setting or other health care situations outside the hospital are not generally recognized as safe and effective (GRAS/GRAE).

Docket No. FDA–2015–N–0101

National Toxicology Program (NTP). 2000. NTP technical report on the toxicology and carcinogenesis studies of diethanolamine (CASRN 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 478. https://ntp.niehs.nih.gov/go/tr478abs

National Toxicology Program (NTP). 1995. NTP technical report on the toxicology and carcinogenesis studies of benzethonium chloride (CASRN 121-54-0) in F344/N rats and B6C3F1 mice (dermal studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 438. https://ntp.niehs.nih.gov/go/tr438abs

National Toxicology Program (NTP). 2004. NTP technical report on the toxicology and carcinogenesis studies of urethane (CASRN 51-79-6), ethanol (CASRN 64-17-5), and urethane/ethanol in B6C3F1 mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 510. https://ntp.niehs.nih.gov/go/tr510abs

National Toxicology Program (NTP). 1988. NTP technical report on the toxicology and carcinogenesis studies of 4-hexylresorcinol in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 330. https://ntp.niehs.nih.gov/go/tr330abs

In accordance with the Paperwork Reduction Act of 1995, the Forest Service is seeking comments from all interested individuals and organizations on the extension with no revision of a currently approved information collection, Qualified Products Lists for Fire Chemicals for Wildland Fire Management.

National Toxicology Program (NTP).  2016. Report on Carcinogens, fourteenth edition.; Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc14.

The United States Consumer Product Safety Commission (Commission or CPSC) issues this final rule prohibiting children’s toys and child care articles that contain concentrations of more than 0.1 percent of diisononyl phthalate (DINP), diisobutyl phthalate (DIBP), di-n-pentyl phthalate (DPENP), di-n-hexyl phthalate (DHEXP), and dicyclohexyl phthalate (DCHP). Section 108 of the Consumer Product Safety Improvement Act of 2008 (CPSIA) established permanent and interim prohibitions on the sale of certain consumer products containing specific phthalates. That provision also directed the CPSC to convene a Chronic Hazard Advisory Panel (CHAP) to study the effects on children’s health of all phthalates and phthalate alternatives as used in children’s toys and child care articles and to provide recommendations to the Commission regarding whether any phthalates or phthalate alternatives, other than those already permanently prohibited, should be prohibited. The CPSIA requires the Commission to promulgate a final rule after receiving the final CHAP report. This rule fulfills that requirement.

National Toxicology Program (NTP). 2015. Handbook for conducting a literature-based health assessment using OHAT approach for systematic review and evidence integration. National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC. January 2015. https://ntp.niehs.nih.gov/go/ohathandbook

National Toxicology Program (NTP). 2016. Report on Carcinogens, fourteenth edition. National Toxicology Program, U.S. Department of Health and Human Services, Public Health Service. Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/roc14

Docket No. CPSC-2014-0033

National Toxicology Program (NTP). 1982. Carcinogenesis bioassay of di(2-ethylhexyl) adipate (CASRN 103-23-1) in F344 rats and B6C3F1 mice (feed study). National Toxicology Program (NTP), Research Triangle Park, NC. NTP technical report series No. 212. https://ntp.niehs.nih.gov/go/tr212

National Toxicology Program (NTP). 1989. Developmental toxicity of dimethyl phthalate (CASRN 131-11-3) administered to CD rats on gestational days 6 through 15. National Toxicology Program. NTP Study: TER88066. January 9, 1989. https://ntp.niehs.nih.gov/go/ter88066abs

National Toxicology Program (NTP). 1997. Reproductive assessment by continuous breeding: evolving study design and summaries of ninety studies. Environmental Health Perspectives 105 (Suppl 1), 199–395. https://ehp.niehs.nih.gov/doi/pdf/10.1289/ehp.97105s1199

National Toxicology Program (NTP). 2000. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-n-butyl phthalate (DBP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dbp/dbp_monograph_final.pdf

National Toxicology Program (NTP). 2002. NTP-CERHR monograph on the potential human reproductive and developmental effects of di(2-ethylhexyl) phthalate (DEHP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dehp/dehp-monograph.pdf

National Toxicology Program (NTP). 2003a. NTP-CERHR monograph on the potential human reproductive and developmental effects of butyl benzyl phthalate (BBP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. March 2003. NIH publication no. 03-4487. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/bb-phthalate/bbp_monograph_final.pdf

National Toxicology Program (NTP). 2003b. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-isodecyl phthalate (DIDP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. April 2003. NIH publication no. 03-4485. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/didp/didp_monograph_final.pdf

National Toxicology Program (NTP). 2003c. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-isononyl phthalate (DINP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. March 2003. NIH publication no. 03-4484. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dinp/dinp_monograph_final.pdf

National Toxicology Program (NTP). 2003d. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-n-hexyl phthalate (DnHP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. March 2003. NIH publication no. 03-4489. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dnhp/dnhp_monograph_final.pdf

National Toxicology Program (NTP). 2006. NTP-CERHR monograph on the potential human reproductive and developmental effects of di(2-ethylhexyl) phthalate (DEHP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. November 2006. NIH publication no. 06-4476. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dehp/dehp-monograph.pdf

National Toxicology Program (NTP). 2000. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-n-butyl phthalate (DBP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dbp/dbp_monograph_final.pdf

National Toxicology Program (NTP). 2003a. NTP-CERHR monograph on the potential human reproductive and developmental effects of butyl benzyl phthalate (BBP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. March 2003. NIH publication no. 03-4487. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/bb-phthalate/bbp_monograph_final.pdf

National Toxicology Program (NTP). 2003c. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-isononyl phthalate (DINP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. March 2003. NIH publication no. 03-4484. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/didp/didp_monograph_final.pdf

National Toxicology Program (NTP). 2003d. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-n-hexyl phthalate (DnHP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. March 2003. NIH publication no. 03-4489. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dnhp/dnhp_monograph_final.pdf

National Toxicology Program (NTP). 2003e. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-n-octyl phthalate (DnOP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. NIH publication no. 03-4488. May 2003. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dnop/dnop_monograph_final.pdf

National Toxicology Program (NTP). 2004. Diethylhexylphthalate: multigenerational reproductive assessment by continuous breeding when diethylhexylphthalate (CASRN 117-81-7) was administered to Sprague Dawley rats in the diet. National Toxicology Program (NTP), Research Triangle Park, NC. NTP Study no. RACB98004. https://ntp.niehs.nih.gov/publications/abstracts/repro/racb98004

National Toxicology Program (NTP). 2006. NTP-CERHR monograph on the potential human reproductive and developmental effects of di(2-ethylhexyl) phthalate (DEHP). Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program, Research Triangle Park, NC. November 2006. NIH publication no. 06-4476. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dehp/dehp-monograph.pdf

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is the lead agency for the implementation of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The Carcinogen Identification Committee (CIC) advises and assists OEHHA in compiling the list of chemicals known to the state to cause cancer as required by Health and Safety Code section 25249.8. The Committee serves as the state’s qualified experts for determining whether a chemical has been clearly shown through scientifically valid testing according to generally accepted principles to cause cancer.

National Toxicology Program (NTP). 1993a. National Toxicology Program, U.S. Department of Health and Human Services. NTP technical report on the toxicology and carcinogenesis studies of coumarin (CASRN 91-64-5) in F344/N rats and B6C3F1 mice (gavage studies). National Toxicology Program Technical Report Series No. 422. https://ntp.niehs.nih.gov/go/tr422abs.

National Toxicology Program (NTP). 1993b. National Toxicology Program, U.S. Department of Health and Human Services. NTP technical report on the toxicology and carcinogenesis studies of 3,4-dihydrocoumarin (CASRN 119-84-6) in F344/N rats and B6C3F1 mice (gavage studies). National Toxicology Program Technical Report Series No. 423. https://ntp.niehs.nih.gov/go/tr423abs.

National Toxicology Program (NTP). 1997. National Toxicology Program, U.S. Department of Health and Human Services. Effect of dietary restriction on toxicology and carcinogenesis studies in F344/N rats and B6C3F1 mice. National Toxicology Program Technical Report Series No. 460. https://ntp.niehs.nih.gov/go/tr460abs.

National Toxicology Program (NTP). 1999a. Rats: Fischer F344 (for study years 1984-1994). Historical Controls Database, National Toxicology Program, from https://ntp.niehs.nih.gov/go/historical_controls.

National Toxicology Program (NTP). 1999b. Mice: B6C3F1 (for study years 1984-1994). Historical Controls Database, National Toxicology Program, from https://ntp.niehs.nih.gov/go/historical_controls.

Effective July 7, 2017, OEHHA is adding penta-bromo-di-phenyl ether mixture [DE-71 (technical grade)] to the list of chemicals known to the state to cause cancer for purposes of Proposition 65, under the \"authoritative bodies\" mechanism.

National Toxicology Program (NTP). 2016. NTP technical report on the toxicology studies of a pentabromodiphenyl ether mixture [DE-71 (technical grade)] (CASRN 32534-81-9) in F344/N rats and B6C3F1/N mice and toxicology and carcinogenesis studies of a pentabromodiphenyl ether mixture [DE-71 (technical grade)] in Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 589. https://doi.org/10.22427/NTP-TR-589.

On May 4, 2017, the Office of Administrative Law approved the amendment of Title 27, California Code of Regulations, section 25705, No Significant Risk Level (NSRL) for the chemical styrene.  The regulation will be effective on July 1, 2017.  This regulation establishes a No Significant Risk Level of 27 micrograms per day for styrene for purposes of Proposition 65.

National Toxicology Program (NTP). 2011. Report on Carcinogens, twelfth edition. US Department of Health and Human Services, Public Health Service, NTP, Research Triangle Park, North Carolina, page 383-391.  https://ntp.niehs.nih.gov/go/roc.

On April 4, 2017, the Office of Administrative Law approved the amendment of Title 27, California Code of Regulations, section 25805, Maximum Allowable Dose Level (MADL) for the chemical ethylene glycol (ingested).  The regulation will be effective on July 1, 2017.  This regulation establishes a MADL of 8,700 (oral) micrograms per day for ethylene glycol (ingested).  

National Toxicology Program (NTP). 2004. NTP-CERHR monograph on the potential human reproductive and developmental effects of ethylene glycol. Research Triangle Park, NC: National Toxicology Program. NTP CERHR MON. 2004 Jan;(11):1-III36. PubMed PMID: 16015391. https://ntp.niehs.nih.gov/ntp/ohat/egpg/ethylene/eg_monograph.pdf

The Centers for Disease Control and Prevention (CDC), as part of its continuing efforts to reduce public burden and maximize the utility of government information, invites the general public and other Federal agencies to take this opportunity to comment on proposed and/or continuing information collections, as required by the Paperwork Reduction Act of 1995. This notice invites comment on ``Childhood Blood Lead Surveillance (CBLS) and Adult Blood Lead Epidemiology and Surveillance (ABLES).'' The National Center for Environmental Health (NCEH) is leading a new three-year information collection request (ICR) that covers two CDC information collections, one for childhood blood lead surveillance by NCEH and another for adult blood lead surveillance by the National Institute for Occupational Safety and Health (NIOSH). CDC requests an annual time burden of 1,120 burden hours for both collections.

National Toxicity Program (NTP). 2012. Monograph on health effects of low-level lead. Research Triangle Park, NC: National Toxicology Program.
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf

This regulation establishes an exemption from the requirement of a tolerance for residues of isoamyl acetate (CAS Reg. No. 123-92-2) when used as an inert ingredient (buffering agent) in pesticide formulations applied to growing crops and raw agricultural commodities after harvest. The Technology Sciences Group on behalf of the Jeneil Biosurfactant Company submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment of an exemption from the requirement of a tolerance.

National Toxicology Program (NTP). 1994. Summary of data for chemical selection isoamyl acetate (CASRN 123-92-2). Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov//sites/default/files/ntp/htdocs/chem_background/exsumpdf/isoamylacetate_508.pdf

This document provides the reasons for EPA's response to a petition it received under the Toxic Substances Control Act (TSCA). The TSCA section 21 petition was received from Earthjustice, Natural Resources Defense Council, Toxic-Free Future, Safer Chemicals, Healthy Families, BlueGreen Alliance, and Environmental Health Strategy Center on December 13, 2016. The petitioners requested that EPA issue an order under TSCA section 4, requiring that testing be conducted by manufacturers (which includes importers) and processors on tetra-bromo-bis-phenol A (``TBBPA'') (CAS No. 79-94-7). After careful consideration, EPA denied the TSCA section 21 petition for the reasons discussed in this document.

National Toxicology Program (NTP). Modified one-generation studies. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/test_info/mog_guidance_508.pdf

This regulation establishes a time-limited tolerance for residues of oxytetracycline in or on fruit, citrus, group 10-10. This action is in response to EPA's granting of an emergency exemption under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) authorizing use of the pesticide in citrus production. This regulation establishes a maximum permissible level for residues of oxytetracycline in or on the commodities in this crop group. The time-limited tolerance expires on December 31, 2019.

National Toxicology Program (NTP). 1987. NTP technical report on toxicology and carcinogenesis studies of oxytetracycline hydrochloride (CASRN 2058-46-0) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 315. https://ntp.niehs.nih.gov/go/tr315abs.

This document announces the availability of EPA's response to a petition it received on November 23, 2016, under section 21 of the Toxic Substances Control Act (TSCA). The TSCA section 21 petition was received from the Fluoride Action Network, Food & Water Watch, Organic Consumers Association, the American Academy of Environmental Medicine, the International Academy of Oral Medicine and Toxicology, and other individual petitioners. The TSCA section 21 petition requested that EPA exercise its authority under TSCA section 6 to ``prohibit the purposeful addition of fluoridation chemicals to U.S. water supplies.'' After careful consideration, EPA has denied the TSCA section 21 petition for the reasons discussed in this document.

National Toxicology Program (NTP). 2016. NTP research report on systematic literature review on the effects of fluoride on learning and memory in animal studies. Research Triangle Park, NC: National Toxicology Program. Research Report 1. https://doi.org/10.22427/NTP-RR-1.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is adopting new Reference Exposure Levels (RELs) for carbonyl sulfide (COS) for use in the Air Toxics Hot Spots Program. RELs are airborne concentrations of a chemical that are not anticipated to result in adverse noncancer health effects for specified exposure durations in the general population, including sensitive subpopulations. The adopted RELs cover different types of exposure to COS in air: infrequent 1-hour exposures, repeated 8-hour exposures, and continuous long-term exposure.

National Toxicology Program (NTP). (2010) Testing status of carbonyl sulfide. Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). https://doi.org/10.22427/NTP-DATA-DTXSID6023949.

As required under section 6(b)(4) of the Toxic Substances Control Act (TSCA), EPA is proposing to establish a process for conducting risk evaluations to determine whether a chemical substance presents an unreasonable risk of injury to health or the environment, without consideration of costs or other non-risk factors, including an unreasonable risk to a potentially exposed or susceptible subpopulation, under the conditions of use. Risk evaluation is the second step, after Prioritization, in a new process of existing chemical substance review and management established under recent amendments to TSCA. This proposed rule identifies the steps of a risk evaluation process including scope, hazard assessment, exposure assessment, risk characterization, and finally a risk determination. EPA is proposing that this process be used for the first ten chemical substances to be evaluated from the 2014 update of the TSCA Work Plan for Chemical Assessments, chemical substances designated as High-Priority Substances during the prioritization process, and those chemical substances for which EPA has initiated a risk evaluation in response to manufacturer requests. The proposed rule also includes the required \"form and criteria'' applicable to such manufacturer requests.

National Toxicology Program (NTP). 2015a. Handbook for conducting a literature-based health assessment using Office of Health Assessment and Translation (OHAT) approach for systematic review and evidence integration. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/go/ohathandbook.

National Toxicology Program (NTP). 2015b. OHAT risk of bias tool. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/go/riskbias.

The Department of Veterans Affairs (VA) amends its adjudication regulations regarding presumptive service connection, adding certain diseases associated with contaminants present in the base water supply at U.S. Marine Corps Base Camp Lejeune (Camp Lejeune), North Carolina, from August 1, 1953, to December 31, 1987. This final rule establishes that veterans, former reservists, and former National Guard members, who served at Camp Lejeune for no less than 30 days (consecutive or nonconsecutive) during this period, and who have been diagnosed with any of eight associated diseases, are presumed to have incurred or aggravated the disease in service for purposes of entitlement to VA benefits.

Docket No. RIN 2900–AP66

NTP (National Toxicology Program). 2014. Report on Carcinogens, thirteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

National Toxicology Program (NTP). 2015. Report on Carcinogens monograph on trichloroethylene (CASRN 79-01-6). Research Triangle Park, NC: National Toxicology Program. RoC Monograph 13. https://doi.org/10.22427/ROC-MGRAPH-13

This final rule amends HUD's lead-based paint regulations to reduce blood lead levels in children under age six (6) who reside in federally-owned or -assisted pre-1978 housing, formally adopting a revised definition of “elevated blood lead level” (EBLL) in children under the age of six (6), in accordance with Centers for Disease Control and Prevention (CDC) guidance. It also establishes more comprehensive testing and evaluation procedures for the housing where such children reside. This final rule also addresses certain additional elements of the CDC guidance pertaining to assisted housing and makes technical corrections and clarifications.

National Toxicity Program (NTP). 2012. Monograph on health effects of low-level lead. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf

The Safe Drinking Water Act (SDWA) requires the U.S. Environmental Protection Agency (EPA) to conduct a review every six years of existing national primary drinking water regulations (NPDWRs) and determine which, if any, need to be revised. The purpose of the review, called the Six- Year Review, is to evaluate current information for regulated contaminants to determine if there is new information on health effects, treatment technologies, analytical methods, occurrence and exposure, implementation and/or other factors that provides a health or technical basis to support a regulatory revision that will improve or strengthen public health protection. EPA has completed a detailed review of 76 NPDWRs and at this time has determined that eight NPDWRs are candidates for regulatory revision. The eight NPDWRs are included in the Stage 1 and the Stage 2 Disinfectants and Disinfection Byproducts Rules, the Surface Water Treatment Rule, the Interim Enhanced Surface Water Treatment Rule and the Long Term 1 Enhanced Surface Water Treatment Rule. EPA requests comments on the eight NPDWRs identified as candidates for revision and will consider comments and data as it proceeds with determining whether further action is needed. In addition, as part of this Six-Year Review, EPA identified 12 other NPDWRs that were or continue to be addressed in recently completed, ongoing or pending regulatory actions. EPA thus excluded those 12 NPDWRs from detailed review. This document is not a final regulatory decision, but rather the initiation of a process that will involve more detailed analyses of factors relevant to deciding whether a rulemaking to revise an NPDWR should be initiated.

National Toxicology Program (NTP). 2014. NTP technical report on the toxicology studies of bromodichloroacetic acid in F344/N rats and B6C3F1/N mice and toxicology and carcinogenesis studies of bromodichloroacetic acid in F344/NTac rats and B6C3F1/N mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 583. https://ntp.niehs.nih.gov/go/tr583abs

National Toxicology Program (NTP). 2016. NTP research report on systematic literature review on the effects of fluoride on learning and memory in animal studies. Research Triangle Park, NC: National Toxicology Program. Research Report 1. https://doi.org/10.22427/NTP-RR-1.

Trichloroethylene (TCE) is a volatile organic compound widely used in industrial and commercial processes and has some limited uses in consumer and commercial products. EPA identified significant health risks associated with TCE use in vapor degreasing and EPA’s proposed determination is that these risks are unreasonable risks. To address these unreasonable risks, EPA is proposing under section 6 of the Toxic Substances Control Act (TSCA) to prohibit the manufacture (including import), processing, and distribution in commerce of TCE for use in vapor degreasing; to prohibit commercial use of TCE in vapor degreasing; to require manufacturers, processors, and distributors, except for retailers of TCE for any use, to provide downstream notification of these prohibitions throughout the supply chain; and to require limited recordkeeping.

National Toxicology Program (NTP). 2011. Trichloroethylene. Report on Carcinogens, twelfth edition, US Department of Health and Human Services, Public Health Service, NTP, Research Triangle Park, North Carolina, https://ntp.niehs.nih.gov/ntp/roc/content/profiles/trichloroethylene.pdf.

The Occupational Safety and Health Administration (OSHA) is amending its existing standards for occupational exposure to beryllium and beryllium compounds. OSHA has determined that employees exposed to beryllium at the previous permissible exposure limits face a significant risk of material impairment to their health. The evidence in the record for this rulemaking indicates that workers exposed to beryllium are at increased risk of developing chronic beryllium disease and lung cancer.

Docket No. OSHA-H005C-2006-0870

National Toxicology Program (NTP). 2014. Beryllium and beryllium compounds. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/berylliumandberylliumcompounds.pdf

National Toxicology Program (NTP). 1993. NTP technical report on the toxicology and carcinogenesis studies of talc (CASRN 14807-96-6) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 421. https://ntp.niehs.nih.gov/go/tr421abs

National Toxicology Program (NTP). 1999. NTP Report on Carcinogens background document for beryllium and beryllium compounds. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc10/be_no_appendices_508.pdf

NTP (National Toxicology Program). 2002. Report on Carcinogens, tenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

National Toxicology Program (NTP). 2014. NTP technical report on the toxicology studies of bromodichloroacetic acid in F344/N rats and B6C3F1/N mice and toxicology and carcinogenesis studies of bromodichloroacetic acid in F344/NTac rats and B6C3F1/N mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 583. https://ntp.niehs.nih.gov/go/tr583abs

National Toxicology Program (NTP). 2016. NTP research report on systematic literature review on the effects of fluoride on learning and memory in animal studies. Research Triangle Park, NC: National Toxicology Program. Research Report 1. https://doi.org/10.22427/NTP-RR-1.

Recent scientific and technological advances have the potential to improve assessment of public health risks posed by chemicals, yet questions remain how best to integrate the findings from the new tools and methods into risk assessment. A new National Academies of Sciences, Engineering, and Medicine report recommends approaches for using 21st century science to evaluate the many factors that lead to health risks and disease, laying the groundwork for a new direction in risk assessment that acknowledges the complexity of disease causation.

National Toxicology Program (NTP). 2004. A National Toxicology Program for the 21st Century: A Roadmap for the Future [online]. https://ntp.niehs.nih.gov//sites/default/files/ntp/about_ntp/ntpvision/ntproadmap_508.pdf.

Trichloroethylene (TCE) is a volatile organic compound widely used in industrial and commercial processes and has some limited uses in consumer and commercial products. EPA identified significant health risks associated with TCE use in aerosol degreasing and for spot cleaning in dry cleaning facilities. EPA has preliminarily determined that these risks are unreasonable risks. To address these unreasonable risks, EPA is proposing under section 6 of the Toxic Substances Control Act (TSCA) to prohibit the manufacture, processing, and distribution in commerce of TCE for use in aerosol degreasing and for use in spot cleaning in dry cleaning facilities; to prohibit commercial use of TCE for aerosol degreasing and for spot cleaning in dry cleaning facilities; to require manufacturers, processors, and distributors, except for retailers of TCE for any use, to provide downstream notification of these prohibitions throughout the supply chain; and to require limited record keeping.

NTP (National Toxicology Program). 2014. Report on Carcinogens, thirteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

EPA is issuing a final rule to implement the Formaldehyde Standards for Composite Wood Products Act, which added Title VI to the Toxic Substances Control Act (TSCA). The purpose of TSCA Title VI is to reduce formaldehyde emissions from composite wood products, which will reduce exposures to formaldehyde and result in benefits from avoided adverse health effects. This final rule includes formaldehyde emission standards applicable to hardwood plywood, medium-density fiberboard, and particleboard, and finished goods containing these products, that are sold, supplied, offered for sale, or manufactured (including imported) in the United States. This final rule includes provisions relating to, among other things, laminated products, products made with no-added formaldehyde resins or ultra low-emitting formaldehyde resins, testing requirements, product labeling, chain of custody documentation and other recordkeeping requirements, enforcement, import certification, and product inventory sell-through provisions, including a product stockpiling prohibition. This final rule also establishes a third-party certification program for hardwood plywood, medium-density fiberboard, and particleboard and includes procedures for the accreditation of third-party certifiers and general requirements for accreditation bodies and third-party certifiers.

NTP (National Toxicology Program). 2014. Report on Carcinogens, thirteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

Effective October 21, 2016, the Office of Environmental Health Hazard Assessment (OEHHA) is adding pentachlorophenol and by-products of its synthesis (complex mixture) to the list of chemicals known to the state to cause cancer for purposes of Proposition 65.

NTP (National Toxicology Program). 2014. Report on Carcinogens, thirteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is announcing the publication of the updated Public Health Goal (PHG) for antimony in drinking water. A PHG is the level of a drinking water contaminant at which adverse health effects are not expected to occur from a lifetime of exposure. The California Safe Drinking Water Act of 1996 requires OEHHA to develop PHGs based exclusively on public health considerations. PHGs published by OEHHA are considered by the State Water Resources Control Board in setting drinking water standards (Maximum Contaminant Levels, or MCLs) for California.

National Toxicology Program (NTP). 1995. NTP technical report on the toxicology and carcinogenesis studies of toxicology and carcinogenesis studies of hydroquinone (CASRN 123-31-9) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 366. https://ntp.niehs.nih.gov/go/tr366abs

National Toxicology Program (NTP). 1992. NTP technical report on the toxicity studies of antimony potassium tartrate (CASRN 28300-74-5) in F344/N rats and B6C3F1 mice (drinking water and intraperitoneal injection studies). Research Triangle Park, NC: National Toxicology Program. Toxicity Report 11. https://ntp.niehs.nih.gov/go/tox11abs

Effective August 5, 2016, the Office of Environmental Health Hazard Assessment (OEHHA) is adding 1-bromopropane (CAS No. 106-94-5) to the list of chemicals known to the state to cause cancer for purposes of Proposition 65.

National Toxicology Program (NTP). 2011. NTP technical report on the toxicology and carcinogenesis studies of 1-bromopropane (CASRN 106-94-5) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 564. https://ntp.niehs.nih.gov/go/tr564abs

Effective July 29, 2016, the Office of Environmental Health Hazard Assessment (OEHHA) is adding bromodichloroacetic acid (CAS No. 71133-14-7) to the list of chemicals known to the state to cause cancer for purposes of Proposition 65.

National Toxicology Program (NTP). 2015. NTP technical report on the toxicology studies of bromodichloroacetic acid (CASRN 71133-14-7) in F344/N rats and B6C3F1/N nice and toxicology and carcinogenesis studies of bromodichloroacetic acid (CASRN 71133-14-7) in F344/NTac rats and B6C3F1/N mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 583. https://doi.org/10.22427/NTP-TR-583

This correction revises the addresses relating to two of the public hearings.

The Department of Energy (DOE or the Department) is proposing to amend its current chronic beryllium disease prevention program regulation. The proposed amendments would improve and strengthen the current provisions and continue to be applicable to DOE Federal and contractor employees who are, were, or potentially were exposed to beryllium at DOE sites.

Docket No. AU-RM-11-CBDPP  

NTP (National Toxicology Program). 2014. Beryllium and beryllium compounds. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/berylliumandberylliumcompounds.pdf

Effective April 22, 2016, the Office of Environmental Health Hazard Assessment (OEHHA) is adding styrene (CAS No. 100-42-5) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65).The listing of styrene is based on formal identification by the National Toxicology Program (NTP), an authoritative body, that the chemical causes cancer. The criteria used by OEHHA for the listing of chemicals under the “authoritative bodies” mechanism can be found in Title 27, Cal. Code of Regs., section 25306.

NTP (National Toxicology Program). 2011. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

On May 11, 2015, Bisphenol A (BPA) was added to the Proposition 65 list of chemicals known to the state to cause reproductive toxicity based on the female reproductive endpoint. Female reproductive toxicity occurs when a chemical damages any aspect of the female reproductive system. BPA is commonly used in certain linings of metal cans and lids of glass bottles containing food and beverages. Under Proposition 65, one year after the listing, beginning May 11, 2016, warnings are required for all exposures to BPA unless the person causing the exposure can show that the exposure when multiplied by 1,000 times has no observable effect.

National Toxicology Program (NTP). 2008. NTP-CERHR Monograph on the potential human reproductive and developmental effects of Bisphenol A. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/bisphenol/bisphenol.pdf

The Occupational Safety and Health Administration (OSHA) is amending its existing standards for occupational exposure to respirable crystalline silica. OSHA has determined that employees exposed to respirable crystalline silica at the previous permissible exposure limits face a significant risk of material impairment to their health. The evidence in the record for this rulemaking indicates that workers exposed to respirable crystalline silica are at increased risk of developing silicosis and other nonmalignant respiratory diseases, lung cancer, and kidney disease. This final rule establishes a new permissible exposure limit of 50 micrograms of respirable crystalline silica per cubic meter of air (50 mg/m3) as an 8-hour time-weighted average in all industries covered by the rule. It also includes other provisions to protect employees, such as requirements for exposure assessment, methods for controlling exposure, respiratory protection, medical surveillance, hazard communication, and recordkeeping.
The final rule is effective on June 23, 2016

NTP (National Toxicology Program). 2011. Silica crystalline (respirable size). Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/silica.pdf

This regulation establishes tolerances for residues of diflubenzuron in or on multiple commodities which are identified and discussed later in this document. Interregional Research Project Number 4 (IR–4) requested these tolerances under the Federal Food, Drug, and Cosmetic Act (FFDCA).

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of para-chloroaniline hydrochloride (CASRN 20265-96-7) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 351. https://ntp.niehs.nih.gov/go/tr351abs

This regulation establishes an exemption from the requirement of a tolerance for residues of benzyl acetate (CAS Reg. No. 140–11–4), when used as an inert ingredient (solvent) in pesticide formulations applied to growing crops only under 40 CFR 180.920. Technology Sciences Group, on behalf of the Huntsman Corporation, submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment of an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of benzyl acetate.

National Toxicology Program (NTP). 1993. NTP technical report on the toxicology and carcinogenesis studies of benzyl acetate (CASRN 140-11-4) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 431. https://ntp.niehs.nih.gov/go/tr431abs

On September 16, 2009, the National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC) announced in the Federal Register https://www.gpo.gov/fdsys/pkg/FR-2009-09-16/pdf/E9-22297.pdf plans to evaluate the scientific data on1-bromopropane (1-BP) and to issue its findings on the potential health risks. A draft document entitled, Criteria for a Recommended Standard: Occupational Exposure to 1-Bromopropane (1-BP), has been developed which contains an assessment of toxicological data and provides recommendations for the safe handling of 1-BP-containing materials.

National Toxicology Program (NTP). 2011. 1-Bromopropane (CASRN 106-94-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-564.
https://cebs.niehs.nih.gov/cebs/publication/TR-564

On January 19, 2016, the Office of Administrative Law approved the adoption of Section 25205, Lead Agency Website to Title 27, Article 2, of the California Code of Regulations. The regulation will be effective on April 1, 2016. This regulation establishes a framework for a website operated by the Office of Environmental Health Hazard Assessment that will provide supplemental information to the public about warnings they receive for exposures to Proposition 65 listed chemicals. This regulation is separate from but related to the pending rulemaking to repeal and adopt a new Article 6 of the California Code of Regulations on clear and reasonable warnings. Note that the lead agency website described in this regulation is not currently operational.

NTP (National Toxicology Program). 2014. Report on Carcinogens, thirteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

The Environmental Protection Agency (EPA) is adding 1-bromopropane to the list of toxic chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA) of 1986 and section 6607 of the Pollution Prevention Act (PPA) of 1990. 1-Bromopropane has been classified by the National Toxicology Program in their 13th Report on Carcinogens as ‘‘reasonably anticipated to be a human carcinogen.’’ The EPA has determined that 1-bromopropane meets the EPCRA section 313(d)(2)(B) criteria because it can reasonably be anticipated to cause cancer in humans.

NTP (National Toxicology Program). 2014. Report on Carcinogens, thirteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

National Toxicology Program (NTP). 2013. Report on Carcinogens. Monograph on 1-bromopropane. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/1bromopropane_508.pdf

NTP (National Toxicology Program). 2014. 1-Bromopropane. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/bromopropane.pdf

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is removing a chemical from the list of chemicals known to the state to cause cancer, for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65).

Diaminotoluene (mixed) was originally added to the Proposition 65 list under the authoritative bodies listing mechanism on January 1, 1990. Regulations governing the listing of chemicals under the authoritative bodies mechanism are published in Title 27, California Code of Regulations, Section 25306. OEHHA received a petition from Big Lots Stores, Inc. for reconsideration of listing for diaminotoluene (mixed) on October 21, 2014. While the US Environmental Protection Agency (US EPA) (1988) document that provided the basis for the listing indicates that the hazard ranking of diaminotoluene (mixed) “is applicable to all isomers of diaminotoluene”, and that the “evidence on potential carcinogenicity from animal studies is “sufficient”, the US EPA document also indicates that “this evidence is based on the carcinogenic properties of the isomer 2,4-diaminotoluene”. No other information on the mixture or individual isomers is included in the US EPA document. For this reason and in accordance with 27 CCR, Section 25306(j), OEHHA referred the chemical to the Carcinogen Identification Committee (CIC) for a recommendation concerning whether the chemical should continue to be included on the list of chemicals known to the state to cause cancer. At a public meeting on November 4, 2015, the CIC determined that diaminotoluene (mixed) has not been clearly shown, through scientifically valid testing according to generally accepted principles, to cause cancer. Therefore, diaminotoluene (mixed) is delisted effective November 20, 2015.

National Toxicology Program (NTP). NTP technical report on the toxicology and carcinogenesis studies of 2,6-xylidine (2,6-dimethylaniline) (CASRN 87-62-7) in Charles River CD rats (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 278. https://ntp.niehs.nih.gov/go/tr278abs

National Toxicology Program (NTP). NTP technical report on the toxicology and carcinogenesis studies of pyridine (CASRN 110-86-1) in F344/N rats, Wistar rats, and B6C3F1 mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 470. https://ntp.niehs.nih.gov/go/tr470abs

National Cancer Institute (NCI). 1978. NCI technical report on the bioassay of 2,5-toluenediamine sulfate (CASRN 6369-59-1) for possible carcinogenicity. Bethesda, MA: National Cancer Institute. Technical Report 126. https://ntp.niehs.nih.gov/go/tr126abs

Environmental Protection Agency (EPA) is denying a petition to remove ethylene glycol monobutyl ether (EGBE) from the category Certain Glycol Ethers under the list of chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA) of 1986 and section 6607 of the Pollution Prevention Act (PPA) of 1990.EPA has reviewed the available data on this chemical and has determined that EGBE does not meet the deletion criterion of EPCRA section 313(d)(3). Specifically, EPA is denying this petition because EPA’s review of the petition and available information resulted in the conclusion that EGBE meets the listing criterion of EPCRA section 313(d)(2)(B) due to its potential to cause serious or irreversible chronic health effects in humans, specifically, liver toxicity and concerns for hematological effects.

National Toxicology Program (NTP). 2000. NTP technical report on the toxicology and carcinogenesis studies 2-butoxyethanol (CASRN 111-76-2) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 484. https://ntp.niehs.nih.gov/go/tr484abs

National Toxicology Program (NTP). 2000. NTP technical report on the toxicology and carcinogenesis studies of acetonitrile (CASRN 75-05-8) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 447. https://ntp.niehs.nih.gov/go/tr447abs

National Toxicology Program (NTP). 1993. NTP technical report on the toxicity studies of ethylene glycol ethers 2-methoxyethanol, 2-ethoxyethanol, 2-butoxyethanol (CASRNs 109-86-4, 110-80-5, and 111-76-2) administered in drinking water to F344/N rats and B6C3F1 mice. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 26. https://ntp.niehs.nih.gov/go/tox26abs

The Food and Drug Administration (FDA) is amending the biologics regulations by removing the general safety test (GST) requirements for biological products. FDA is finalizing this action because the existing codified GST regulations are duplicative of requirements that are also specified in biologics license applications (BLAs), or are no longer necessary or appropriate to help ensure the safety, purity, and potency of licensed biological products. FDA is taking this action as part of its retrospective review of its regulations to promote improvement and innovation, in response to the Executive order.

Docket No. FDA-2014-N-1110

Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Authorization Act of 2000 (42 U.S.C. 2851–3). https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/about_docs/pl106545.pdf.

Effective June 19, 2015, the Office of Environmental Health Hazard Assessment (OEHHA) is adding ethylene glycol (ingested) (CAS No. 107-21-1) to the list of chemicals known to the state to cause reproductive toxicity for purposes of Proposition 65.

National Toxicology Program (NTP). 2004. NTP-CERHR monograph on the potential human reproductive and developmental effects of ethylene glycol. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/egpg/ethylene/eg_monograph.pdf

Eight synthetic flavorings—which may be found in ice cream, baked goods, candy and beverages—are known to cause cancer in lab animals, and should be banned by the U.S. Food and Drug Administration, a coalition of leading health groups said in a petition filed with the agency today.

National Toxicology Program (NTP). 2006. NTP technical report on the toxicology and carcinogenesis studies of benzophenone (CASRN 119-61-9) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 533. https://ntp.niehs.nih.gov/go/tr533abs

National Toxicology Program (NTP). 2000. NTP Report on Carcinogens background document for methyleugenol. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc10/me_no_appendices_508.pdf

National Toxicology Program (NTP). 2000. NTP technical report on the toxicology and carcinogenesis studies of methyleugenol (CASRN 93-15-2) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 491. https://ntp.niehs.nih.gov/go/tr491abs

National Toxicology Program (NTP). 2010. NTP technical report on the toxicology and carcinogenesis studies of beta-myrcene (CASRN 123-35-3) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 557. https://ntp.niehs.nih.gov/go/tr557abs

National Toxicology Program (NTP). 2011. NTP technical report on the toxicology and carcinogenesis studies of pulegone (CASRN 89-82-7) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 563. https://ntp.niehs.nih.gov/go/tr563abs

National Toxicology Program (NTP). 2000. NTP technical report on the toxicology and carcinogenesis studies of pyridine (CASRN 110-86-1) in F344/N rats, Wistar Rats, and B6C3F1 mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 470. https://ntp.niehs.nih.gov/go/tr470abs

NTP (National Toxicology Program). 2014. Styrene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/styrene.pdf

National Toxicology Program (NTP). 2008. NTP Report on Carcinogens background document for styrene. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/2010/finalbds/styrene_final_508.pdf

National Toxicology Program (NTP). 2000. NTP technical report on the toxicology and carcinogenesis studies of 2,4-Hexadienal (CASRN 142-83-6) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 509. https://ntp.niehs.nih.gov/go/tr509abs

Effective May 11, 2015, the Office of Environmental Health Hazard Assessment (OEHHA) is adding bisphenol A (BPA) (CAS No. 80-05-7) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65).

National Toxicology Program (NTP). 2008. NTP-CERHR monograph on the potential human reproductive and eevelopmental effects of bisphenol A. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/bisphenol/bisphenol.pdf

National Toxicology Program CLARITY-BPA program. https://ntp.niehs.nih.gov/go/bpa [accessed July 2015]

The Office of Environmental Health Hazard Assessment (OEHHA) convened a meeting of the Proposition 65 Carcinogen Identification Committee (CIC) on November 19, 2014, at the California Environmental Protection Agency Headquarters Building in Sacramento, California. The Committee considered whether or not dibenzanthracenes (as a chemical group), dibenz[a,c]anthracene, dibenz[a,j]anthracene, and N-nitrosomethyl-n-alkylamines with alkyl chain lengths of 3 through 12 and 14 carbons should be listed under Proposition 65 as known to the state to cause cancer.

NTP (National Toxicology Program). 1980. Report on Carcinogens, first edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

Effective March 27, 2015,the Office of Environmental Health Hazard Assessment (OEHHA) is adding beta-myrcene(CAS No. 123-35-3)to the list of chemicals known to the state to cause cancer for purposes of Proposition 65

National Toxicology Program (NTP). 2010. NTP technical report on the toxicology and carcinogenesis studies of beta-myrcene (CASRN 123-35-3) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 557. https://ntp.niehs.nih.gov/go/tr557abs

EPA is developing a significant new use rule (SNUR) under section 5(a)(2) of the Toxic Substances Control Act (TSCA) for 2,4-toluene diisocyanate, 2,6-toluene diisocyanate, toluene diisocyanate unspecified isomers (these three chemical substances are hereafter referred to as toluene diisocyanates or TDI) and related compounds.

NTP (National Toxicology Program). 2011. Toluene diisocyanates. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/toluenediisocyanates.pdf

Under the Toxic Substances Control Act (TSCA), EPA is promulgating a significant new use rule (SNUR) to add nine benzidine-based chemical substances to the existing SNUR on benzidine-based chemical substances. With respect to both the newly-added benzidine-based chemical substances and the previously-listed benzidine-based chemical substances, this rule makes inapplicable the exemption relating to persons that import or process substances as part of an article. EPA is also promulgating a SNUR for di-n-pentyl phthalate (DnPP) and a SNUR for alkanes, C12-13, chloro. These actions require persons who intend to manufacture (defined by statute to include import) or process these chemical substances for an activity that is designated as a significant new use to notify EPA at least 90 days before commencing such manufacture or processing. The required notifications will provide EPA with the opportunity to evaluate activities associated with a significant new use and, if necessary based on the information available at that time, an opportunity to protect against potential unreasonable risks, if any, from that activity before it occurs. EPA is also making a technical amendment to the codified list of control numbers for approved information collection activities so that it includes the control number assigned by the Office of Management and Budget (OMB) to the information collection activities contained in this rule. This final rule is effective February 27, 2015.

National Toxicology Program (NTP). 2012. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of butyl benzyl phthalate (BBP). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/bb-phthalate/bbp_monograph_final.pdf

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-n-octyl phthalate (DnOP). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dnop/dnop_monograph_final.pdf

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-isononyl phthalate (DINP). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dinp/dinp_monograph_final.pdf

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-isodecyl phthalate (DIDP). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/didp/didp_monograph_final.pdf

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental dffects of di(2-ethylhexyl) phthalate (DEHP). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dehp/dehp-monograph.pdf

National Toxicology Program (NTP). 2003. Testing status of di-n-pentylphthalate (131-18-0). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://cebs.niehs.nih.gov/cebs/test_article/131-18-0

This notice announces the availability of Set 26 Toxicological Profiles for review and comment. Comments can include additional information or reports on studies about the health effects of Set 26 substances. Although ATSDR considered key studies for each of these substances during the profile development process, this Federal Register notice solicits any relevant, additional studies, particularly unpublished data. ATSDR will evaluate the quality and relevance of such data or studies for possible inclusion into the profile. ATSDR remains committed to providing a public comment period for this document as a means to best serve public health and our clients. The Set 26 Toxicological Profiles are available online at https://www.atsdr.cdc.gov/toxprofiles/index.asp and https://www.regulations.gov/#!home, docket ATSDR–2014–0001.The Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA), § 104(i)(3),[42 U.S.C. 9604(i)(3)], directs the ATSDR administrator to prepare Toxicological Profiles of priority hazardous substances and, as necessary, to revise and publish each updated toxicological profile.

National Toxicology Program (NTP). 1988a. Developmental toxicity evaluation of 1,1,1-trichloroethane (CASRN 71-55-6) administered to CD rats. Final report part 1. Research Triangle Park, NC: National Toxicology Program. PB88131321. https://ntp.niehs.nih.gov/go/t0151abs

National Toxicology Program (NTP). 1988b. Developmental toxicity evaluation of 1,1,1-trichloroethane (CASRN 71-55-6) administered to CD rats. Final report part 2. Research Triangle Park, NC: National Toxicology Program. PB88134101. https://ntp.niehs.nih.gov/go/t0151abs

NTP (National Toxicology Program). 1989a. 1,1,1-Trichloroethane. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tetrachloroethylene.pdf

NTP (National Toxicology Program). 1989b. Fiscal year 1989 annual plan. NTP 89167. National Toxicology Program. U.S. Department of Health and Human Services, 102-104. https://ntp.niehs.nih.gov/go/annualreport

National Toxicology Program (NTP). 1996. NTP technical report on renal toxicity studies of selected halogenated ethanes administered by gavage to F344/N rats. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 45. https://ntp.niehs.nih.gov/go/tox45abs

National Toxicology Program (NTP). 2000. NTP technical report on toxicity studies of 1,1,1-trichloroethane (CASRN 71-55-6) administered in microcapsules in feed to F344/N rats and B6C3F1 mice. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 41. https://ntp.niehs.nih.gov/go/tox41abs

National Toxicology Program (NTP). 1986. Toxicology and carcinogenesis studies of tetrachloroethylene (perchloroethylene) (CASRN 127-18-4) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 311. https://ntp.niehs.nih.gov/go/tr311abs

NTP (National Toxicology Program). 2011. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

NTP (National Toxicology Program). 2016. Report on Carcinogens, fourteenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

The Office of Environmental Health Hazard Assessment (OEHHA) has developed a PBPK (physiologically based pharmacokinetic) model describing the relationship between airborne lead and blood levels in workers and released it in October 2013. The model was developed at the request of the California Department of Public Health (CDPH) and is being used to understand workplace exposures.

NTP (National Toxicology Program). 2011. Lead and lead compounds. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/lead.pdf

This action supplements our proposed amendments to the national emission standards for hazardous air pollutants (NESHAP) for the Primary Aluminum Production source category published in the Federal Register onDecember 6, 2011. In that action, the Environmental Protection Agency (EPA) proposed amendments based on the initial residual risk and technology reviews (RTR) for this source category, and also proposed certain emission limits reflecting performance of Maximum Achievable Control Technology (MACT). Today’s action reflects a revised technology review and a revised residual risk analysis for the Primary Aluminum Production source category and proposes new and revised emission standards based on those analyses, newly obtained emissions test data, and comments we received in response to the 2011 proposal, including certain revisions to the technology-based standards reflecting performance of MACT. This action also proposes new compliance requirements to meet the revised standards. This action, if adopted, will provide improved environmental protection regarding potential emissions of hazardous air pollutant (HAP) emissions from primary aluminum production facilities.

NTP (National Toxicology Program). 2011. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

In order to clarify the scope of the listing, OEHHA is referring diaminotoluene (mixed) to the CIC for a determination as to whether the chemical should continue to be included on the list of chemicals known to the state to cause cancer pursuant to Title 27, Cal. Code of Regs., section 25306 (j).

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of two pentachlorophenol technical-grade mixtures in B6C3F1 mice. Research Triangle Park, NC: National Toxicology Program. Technical Report 349. NIH Publication No. 89-2804. https://ntp.niehs.nih.gov/go/tr349abs.

This action supplements our proposed amendments to the national emission standards for hazardous air pollutants (NESHAP) for the Ferroalloys Production source category published in the Federal Register on November 23, 2011. In that action, the Environmental Protection Agency (EPA) proposed amendments based on the initial technology and residual risk reviews for this source category. Today’s action presents a revised technology review and a revised residual risk review for the Ferroalloys Production source category and proposes revisions to the standards based on those reviews. This action also proposes new compliance requirements to meet the revised standards. This action would result in significant environmental improvements through the reduction of fugitive manganese emissions and through more stringent emission limits for several processes.

NTP (National Toxicology Program). Report on Carcinogens, twelfth edition.; Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc.

OSHA is reviewing its overall approach to managing chemical exposures in the workplace and seeks stakeholder input about more effective and efficient approaches that addresses challenges found with the current regulatory approach. This review involves considering issues related to updating permissible exposure limits (PELs), as well as examining other strategies that could be implemented to address workplace conditions where workers are exposed to chemicals. The notice details the role of past court decisions on the Agency’s current approach to chemical management for the purpose of informing stakeholders of the legal framework in which the Agency must operate. It then describes possible modifications of existing processes, along with potential new sources of data and alternative approaches the Agency may consider. The Agency is particularly interested in information about how it may take advantage of newer approaches, given its legal requirements. This RFI is concerned primarily with chemicals that cause adverse health effects from long-term occupational exposure, and is not related to activities being conducted under Executive Order 13650, Improving Chemical Facility Safety and Security.

National Toxicology Program (NTP). (2013). High throughput screening initiative. Retrieved from: https://ntp.niehs.nih.gov/go/28213.

The Office of Environmental Health Hazard Assessment (OEHHA) is adopting new and revised Reference Exposure Levels (RELs) for benzene.

National Toxicology Program (NTP). 1986. NTP technical report on the toxicology and carcinogenesis studies of benzene (CASRN 71-43-2) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 289. https://ntp.niehs.nih.gov/go/tr289abs

Effective May 2, 2014, the Office of Environmental Health Hazard Assessment (OEHHA) is adding N,N-dimethyl-p-toluidine to the list of chemicals known to the State to cause cancer for purposes of Proposition 65.

National Toxicology Program (NTP). 2012. National Toxicology Program. NTP technical report on the toxicology and carcinogenesis studies of N,N-dimethyl-p-toluidine (CASRN 99-97-8) in F344/N rats and B6C3F1/N mice (gavage studies). Technical Report Series No. 579. NIH Publication No. 12-5921. U.S. Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/tr579abs

This action establishes more stringent vehicle emissions standards and will reduce the sulfur content of gasoline beginning in 2017, as part of a systems approach to addressing the impacts of motor vehicles and fuels on air quality and public health. The gasoline sulfur standard will make emission control systems more effective for both existing and new vehicles, and will enable more stringent vehicle emissions standards. The vehicle standards will reduce both tailpipe and evaporative emissions from passenger cars, light-duty trucks, medium-duty passenger vehicles, and some heavy-duty vehicles. This will result in significant reductions in pollutants such as ozone, particulate matter, and air toxics across the country and help state and local agencies in their efforts to attain and maintain health-based National Ambient Air Quality Standards. Motor vehicles are an important source of exposure to air pollution both regionally and near roads. These vehicle standards are intended to harmonize with California's Low Emission Vehicle program, thus creating a federal vehicle emissions program that will allow automakers to sell the same vehicles in all 50 states. The vehicle standards will be implemented over the same timeframe as the greenhouse gas/fuel efficiency standards for light-duty vehicles (promulgated by EPA and the National Highway Safety Administration in 2012), as part of a comprehensive approach toward regulating emissions from motor vehicles.

NTP (National Toxicology Program). Benzene. Report on Carcinogens, twelfth edition.; Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/benzene.pdf.

NTP (National Toxicology Program). 1,3-butadiene. Report on Carcinogens, twelfth edition.; Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/butadiene.pdf.

NTP (National Toxicology Program). Formaldehyde. Report on Carcinogens, twelfth edition.; Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/formaldehyde.pdf.

NTP (National Toxicology Program). Acetaldehyde. Report on Carcinogens, twelfth edition.; Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acetaldehyde.pdf.

NTP (National Toxicology Program). Naphthalene. Report on Carcinogens, twelfth edition.; Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/naphthalene.pdf.

This regulation establishes tolerances for residues of diflubenzuron (N-[[(4-chlorophenyl)amino]carbonyl]-2,6-difluorobenzimide) in or on fruit, citrus, group 10-10 and citrus, oil. Chemtura Corporation, requested these tolerances under the Federal Food, Drug, and Cosmetic Act (FFDCA).

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of para-chloroaniline hydrochloride in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 351. https://ntp.niehs.nih.gov/go/tr351abs

The Food and Drug Administration (FDA) is amending the food additive regulations to provide for the expanded safe use of acacia (gum arabic) in foods. This action is in response to a petition filed by Nexira.

National Toxicology Program (NTP). 1982. NTP technical report on the carcinogenesis bioassay of gum arabic (CASRN 9000-01-5) in F344 rats and B6C3F1 mice (feed study). Research Triangle Park, NC: National Toxicology Program. Technical Report 227. https://ntp.niehs.nih.gov/go/tr227abs

EPA is adding ortho-nitrotoluene (o-nitrotoluene) to the list of toxic chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA) of 1986 and section 6607 of the Pollution Prevention Act (PPA) of 1990. o-Nitrotoluene has been classified by the National Toxicology Program in its 12th Report on Carcinogens as “reasonably anticipated to be a human carcinogen.” EPA has determined that o-nitrotoluene meets the EPCRA section 313(d)(2)(B) criteria because it can reasonably be anticipated to cause cancer in humans.

National Toxicology Program (NTP). 2011. Ortho-nitrotoluene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitrotoluene.pdf

On May 2, 2013, the Administrator of the World Trade Center (WTC) Health Program received a petition (Petition 002) requesting the addition of prostate cancer to the List of WTC-Related Health Conditions (List) covered in the WTC Health Program. In this final rule, the Administrator adds malignant neoplasm of the prostate (prostate cancer) to the List in the WTC Health Program regulations.

NTP (National Toxicology Program). 2011. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

EPA issued a proposed rule in the Federal Register of June 10, 2013, concerning a third-party certification framework for the formaldehyde standards for composite wood products. After receiving requests for an extension, EPA extended the comment period from August 9, 2013, to August 26, 2013. EPA received additional comments and believes it is appropriate to further extend the comment period in order to give stakeholders additional time to assess the impacts of the proposal, review technical documents in the docket, and prepare comments. This document extends the comment period from August 26, 2013, to September 25, 2013.

NTP (National Toxicology Program). 2011. Formaldehyde. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/formaldehyde.pdf

This regulation establishes an exemption from the requirement of a tolerance for residues of guar guar hydroxypropyltrimethylammonium chloride (CAS Reg. No. 71329-50-5) when used as an inert ingredient (thickener/drift reduction agent) in pesticide formulations applied to growing crops. SciReg. Inc., on behalf of Rhodia Inc., submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment of an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of guar hydroxypropyltrimethylammonium chloride.

National Toxicology Program (NTP). 1982. NTP technical report on the carcinogenesis bioassay of guar gum (CASRN  9000-30-0) in F344 rats and B6C3F1 mice (feed study). Research Triangle Park, NC: National Toxicology Program. Technical Report 229. https://ntp.niehs.nih.gov/go/tr229abs

Effective April 19, 2013, the Office of Environmental Health Hazard Assessment (OEHHA) is removing bisphenol A (BPA) (CAS No. 80-05-7) from the list of chemicals known to the State to cause cancer or reproductive toxicity for purposes of Proposition 65.1 The chemical was added to the list on April 11, 2013 based on reproductive endpoints (developmental toxicity).

National Toxicology Program (NTP). 2008. NTP-CERHR monograph on the potential human reproductive and developmental effects of bisphenol A. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf

National Toxicology Program (NTP). (1985) Bisphenol A: reproduction and fertility assessment in CD-1 mice when administered in the feed. NTP-85-192. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/go/racb84080abs

On September 12, 2012, HHS published a final rule in the Federal Register adding certain types of cancer to the List of World Trade Center (WTC)-Related Health Conditions (List) established in the WTC Health Program regulation. Breast cancer was included on the List, although only individuals experiencing nighttime sleep disruption as a result of response and cleanup activities involving shiftwork are currently considered to have experienced exposure relevant for certification. A recent publication in The Lancet Oncology by the International Agency for Research on Cancer (IARC) concludes that there is limited evidence that polychlorinated biphenyls (PCBs) cause breast cancer in humans. As described below, the WTC Program Administrator (Administrator) has found that PCBs were present in WTC dust in the New York City disaster area and, accordingly, the Program will now certify breast cancer in eligible WTC responders and survivors who were exposed to either shiftwork/nighttime sleep disruption or PCBs as a result of the 9/11 attacks.

National Toxicology Program (NTP). 2011. Polychlorinated biphenyls. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/polychlorinatedbiphenyls.pdf

The Consumer Product Safety Commission (CPSC or Commission) codifies its statement of policy on animal testing that provides guidance for manufacturers of products subject to the Federal Hazardous Substances Act (FHSA) regarding replacement, reduction, and refinement of animal testing methods. Effective January 9, 2013.

ICCVAM Authorization Act of 2000
https://ntp.niehs.nih.gov//sites/default/files/iccvam/docs/about_docs/pl106545.pdf

EPA and NHTSA, on behalf of the Department of Transportation, are issuing final rules to further reduce greenhouse gas emissions and improve fuel economy for light-duty vehicles for model years 2017 and beyond. On May 21, 2010, President Obama issued a Presidential Memorandum requesting that NHTSA and EPA develop through notice and comment rulemaking a coordinated National Program to improve fuel economy and reduce greenhouse gas emissions of light-duty vehicles for model years 2017-2025, building on the success of the first phase of the National Program for these vehicles for model years 2012-2016. This final rule, consistent with the President's request, responds to the country's critical need to address global climate change and to reduce oil consumption. NHTSA is finalizing Corporate Average Fuel Economy standards for model years 2017-2021 and issuing augural standards for model years 2022-2025 under the Energy Policy and Conservation Act, as amended by the Energy Independence and Security Act. NHTSA will set final standards for model years 2022-2025 in a future rulemaking. EPA is finalizing greenhouse gas emissions standards for model years 2017-2025 under the Clean Air Act. These standards apply to passenger cars, light-duty trucks, and medium-duty passenger vehicles, and represent the continuation of a harmonized and consistent National Program. Under the National Program automobile manufacturers will be able to continue building a single light-duty national fleet that satisfies all requirements under both programs while ensuring that consumers still have a full range of vehicle choices that are available today. EPA is also finalizing minor changes to the regulations applicable to model years 2012-2016, with respect to air conditioner performance, nitrous oxides measurement, off-cycle technology credits, and police and emergency vehicles.

National Toxicology Program (NTP). 2012. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

Title I of the James Zadroga 9/11 Health and Compensation Act of 2010 amended the Public Health Service Act (PHS Act) to establish the World Trade Center (WTC) Health Program. The WTC Health Program, which is administered by the Director of the National Institute for Occupational Safety and Health (NIOSH), within the Centers for Disease Control and Prevention (CDC), provides medical monitoring and treatment to eligible firefighters and related personnel, law enforcement officers, and rescue, recovery, and cleanup workers who responded to the September 11, 2001, terrorist attacks in New York City, at the Pentagon, and in Shanksville, Pennsylvania, and to eligible survivors of the New York City attacks. In accordance with WTC Health Program regulations, which establish procedures for adding a new condition to the list of covered health conditions, this final rule adds to the List of WTC-Related Health Conditions the types of cancer proposed for inclusion by the notice of proposed rulemaking.

National Toxicology Program (NTP). 2012. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

Effective July 24, 2012, the Office of Environmental Health Hazard Assessment (OEHHA) is adding two chemicals, isopyrazam (CAS No. 881685-58-1) and 3,3’,4,4’‑tetrachloroazobenzene (CAS No. 14047-09-7), to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (commonly known as Proposition 651)

National Toxicology Program (NTP). 1998. NTP technical report on the toxicity studies of 3,3',4,4'-tetrachloroazobenzene (CASRN 14047-09-7) administered by gavage to F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Toxicity Report 65.
https://ntp.niehs.nih.gov/go/tox65abs

The Toxic Substances Control Act (TSCA) Interagency Testing Committee (ITC) transmitted its 69th Report to the EPA Administrator on April 5, 2012. In the 69th ITC Report, which is included with this notice, the ITC is adding a category of cadmium compounds including any chemical that contains cadmium as part of that chemical's structure, 6 non-phthalate plasticizers, 25 phosphate ester flame retardants, 2 other flame retardants, 9 chemicals to which children living near hazardous waste sites may be exposed, and a category of 69 diisocyanates and related compounds (including 14 Action Plan chemicals and 55 related compounds) to the TSCA Priority Testing List. In addition, the ITC is removing 103 cadmium compounds and 14 High Production Volume (HPV) Challenge Program orphan chemicals from the Priority Testing List during this reporting period (June to November 2011). The ITC is adding the category of cadmium compounds and removing 103 cadmium compounds to provide a more comprehensive approach to assessing cadmium compounds' safety.

National Toxicology Program (NTP). 2012. Tris(1,3-dichloro-2-propyl) phosphate (13674-87-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC: National Toxicology Program.
https://cebs.niehs.nih.gov/cebs/test_article/13674-87-8

The U.S. Environmental Protection Agency (EPA) is announcing the IRIS 2012 agenda and requesting scientific information on health effects that may result from exposure to the chemical substances on the agenda, including assessments that EPA is starting this year.

National Toxicology Program (NTP). 2012. NTP monograph on health effects of low-level lead. Research Triangle Park, NC: National Toxicology Program.
https://ntp.niehs.nih.gov/ntp/ohat/lead/final/monographhealtheffectslowlevellead_newissn_508.pdf

EPA is proposing to issue a test rule under Toxic Substances Control Act (TSCA) section 4(a)(1)(B) to require manufacturers and processors of 23 high production volume (HPV) chemical substances to develop screening-level health, environmental, and fate data based on the potential for substantial exposures of workers and consumers to these chemicals. EPA is also proposing to issue simultaneously a significant new use rule (SNUR) for another 22 HPV chemical substances under TSCA section 5(a)(2). The SNUR would require persons to file a significant new use notice (SNUN) with EPA prior to manufacturing, importing, or processing any of these chemical substances for use in a consumer product or for any use, or combination of uses, that is reasonably likely to expose 1,000 or more workers at a single corporate entity. The required notification would provide EPA with the opportunity to evaluate the intended use and, if necessary, to prohibit or limit that activity before it occurs. EPA is also soliciting comment on a number of issues with regard to both the test rule and the SNUR.

National Toxicology Program (NTP). 2003. Test method protocol for the BALB/c 3T3 neutral red uptake cytotoxicity test, a test for basal cytotoxicity for an in vitro validation study—phase III. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/sites/default/files/iccvam/methods/acutetox/invidocs/phiiiprot/3t3phiii.pdf

National Toxicology Program (NTP). 2003. Test method protocol for the NHK neutral red uptake cytotoxicity test, a test for basal cytotoxicity for an in vitro validation study—phase III. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. 
https://ntp.niehs.nih.gov//sites/default/files/iccvam/methods/acutetox/invidocs/phiiiprot/nhkphiii.pdf

National Toxicology Program (NTP). 2003. Test method protocol for solubility determination, in vitro cytotoxicity validation study—phase III. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/sites/default/files/iccvam/methods/acutetox/invidocs/phiiiprot/solphiii.pdf

The Food and Drug Administration (FDA) is establishing a list of harmful and potentially harmful constituents (HPHCs) in tobacco products and tobacco smoke (the established HPHC list) as required by the Federal Food, Drug, and Cosmetic Act (the FD&C Act).

National Toxicology Program (NTP). 2012. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

In this final rule, OSHA is modifying its Hazard Communication Standard (HCS) to conform to the United Nations' Globally Harmonized System of Classification and Labelling of Chemicals (GHS). OSHA has determined that the modifications will significantly reduce costs and burdens while also improving the quality and consistency of information provided to employers and employees regarding chemical hazards and associated protective measures. Consistent with the requirements of Executive Order 13563, which calls for assessment and, where appropriate, modification and improvement of existing rules, the Agency has concluded this improved information will enhance the effectiveness of the HCS in ensuring that employees are apprised of the chemical hazards to which they may be exposed, and in reducing the incidence of chemical-related occupational illnesses and injuries.The modifications to the standard include revised criteria for classification of chemical hazards; revised labeling provisions that include requirements for use of standardized signal words, pictograms, hazard statements, and precautionary statements; a specified format for safety data sheets; and related revisions to definitions of terms used in the standard, and requirements for employee training on labels and safety data sheets. OSHA is also modifying provisions of other standards, including standards for flammable and combustible liquids, process safety management, and most substance-specific health standards, to ensure consistency with the modified HCS requirements. The consequences of these modifications will be to improve safety, to facilitate global harmonization of standards, and to produce hundreds of millions of dollars in annual savings.

National Toxicology Program (NTP). 2012. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

The Food and Drug Administration (FDA) is announcing the availability of a final recommendation for the revision of the permitted daily exposure (PDE) for the solvent cumene according to the maintenance procedures for the guidance for industry entitled “Q3C Impurities: Residual Solvents.” The recommendation was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH).

National Toxicology Program (NTP). 1996. NTP technical report on the toxicology and carcinogenesis studies of 2,2-bis(bromomethyl)-1,3-propanediol (FR-1138) (CASRN  3296-90-0) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-452.
https://ntp.niehs.nih.gov/go/tr452abs

On May 3, 2011, under authority of Clean Air Act (CAA) sections 111 and 112, the EPA proposed both national emission standards for hazardous air pollutants (NESHAP) from coal- and oil-fired electric utility steam generating units (EGUs) and standards of performance for fossil-fuel-fired electric utility, industrial-commercial-institutional, and small industrial-commercial-institutional steam generating units (76 FR 24976). After consideration of public comments, the EPA is finalizing these rules in this action.

National Toxicology Program (NTP). 1996. NTP technical report on the toxicology and carcinogenesis studies of nickel subsulfide (CASRN 12035-72-2) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-453.
https://ntp.niehs.nih.gov/go/tr453abs

National Toxicology Program (NTP). 1996. NTP technical report on the toxicology and carcinogenesis studies of nickel sulfate hexahydrate (CASRN 10101-97-0) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-454.
https://ntp.niehs.nih.gov/go/tr454abs

With the issuance of this final rule, the Administrator of the Drug Enforcement Administration (DEA) places the substance carisoprodol, including its salts, isomers, and salts of isomers, whenever the existence of such salts, isomers, and salts of isomers is possible, into Schedule IV of the Controlled Substances Act (CSA). This action is pursuant to the CSA which requires that such actions be made on the record after opportunity for a hearing.

National Toxicology Program (NTP). 2000. NTP technical report on the toxicity studies carisoprodol (CASRN 78-44-4) administered to F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TOX-56.
https://ntp.niehs.nih.gov/go/tox56abs

EPA is promulgating this final rule under section 4(a)(1)(B) of the Toxic Substances Control Act (TSCA) to require manufacturers, importers, and processors to conduct testing to obtain screening level data for health and environmental effects and chemical fate for 15 high production volume (HPV) chemical substances listed in this final rule. This test data is needed in order to help EPA to determine whether these 15 HPV chemical substances pose a risk to human health and/or environmental safety. Based on comments received by EPA on the proposed rule for this final rule, EPA has determined that only 15 of the 29 HPV chemical substances proposed for testing meet the criteria for testing at this time.

National Toxicology Program (NTP). 2002. Metabolism, toxicity, and predicted carcinogenicity studies of diazoaminobenzene (CASRN 136-35-6) administered dermally to F344/N rats and B6C3F1 mice. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TOX-73.
https://ntp.niehs.nih.gov/go/tox73abs

In accordance with the Paperwork Reduction Act of 1995, the Forest Service is seeking comments from all interested individuals and organizations on the extension (without revision) of a currently approved information collection, Qualified Products List for Water Enhancers (Gels) for Wildland Firefighting.

National Toxicology Program (NTP). 2011. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

In accordance with the Paperwork Reduction Act of 1995, the Forest Service is seeking comments from all interested individuals and organizations on the extension (with contact revision) of a currently approved information collection, Qualified Products List for Long-Term Retardant For Wildland Firefighting.

National Toxicology Program (NTP). 2011. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

EPA and NHTSA, on behalf of the Department of Transportation, are each finalizing rules to establish a comprehensive Heavy-Duty National Program that will reduce greenhouse gas emissions and fuel consumption for on-road heavy-duty vehicles, responding to the President's directive on May 21, 2010, to take coordinated steps to produce a new generation of clean vehicles. NHTSA's final fuel consumption standards and EPA's final carbon dioxide (CO2) emissions standards are tailored to each of three regulatory categories of heavy-duty vehicles: Combination Tractors; Heavy-duty Pickup Trucks and Vans; and Vocational Vehicles. The rules include separate standards for the engines that power combination tractors and vocational vehicles. Certain rules are exclusive to the EPA program. These include EPA's final hydrofluorocarbon standards to control leakage from air conditioning systems in combination tractors, and pickup trucks and vans. These also include EPA's final nitrous oxide (N2O) and methane (CH4) emissions standards that apply to all heavy-duty engines, pickup trucks and vans.EPA's final greenhouse gas emission standards under the Clean Air Act will begin with model year 2014. NHTSA's final fuel consumption standards under the Energy Independence and Security Act of 2007 will be voluntary in model years 2014 and 2015, becoming mandatory with model year 2016 for most regulatory categories. Commercial trailers are not regulated in this phase of the Heavy-Duty National Program.The agencies estimate that the combined standards will reduce CO2 emissions by approximately 270 million metric tons and save 530 million barrels of oil over the life of vehicles sold during the 2014 through 2018 model years, providing over $7 billion in net societal benefits, and $49 billion in net societal benefits when private fuel savings are considered.EPA is also finalizing provisions allowing light-duty vehicle manufacturers to use CO2 credits to meet the light-duty vehicle N2O and CH4 standards, technical amendments to the fuel economy provisions for light-duty vehicles, and a technical amendment to the criteria pollutant emissions requirements for certain switch locomotives.

National Toxicology Program (NTP). 2011. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

In accordance with the Paperwork Reduction Act of 1995, the Forest Service is seeking comments from all interested individuals and organizations on the extension (without revision) of a currently approved information collection, Qualified Products List for Class A Foams for Wildland Firefighting.

National Toxicology Program (NTP). 2011. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

The Food and Drug Administration (FDA) is requesting comments, including scientific and other information, concerning the harmful and potentially harmful constituents (HPHCs) in tobacco products and tobacco smoke. This information will assist the Agency in establishing a list of HPHCs in tobacco products and tobacco smoke (the HPHC list).

National Toxicology Program (NTP). 2011. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) today published the nation’s first public health goal (PHG) for hexavalent chromium in drinking water. Hexavalent Chromium in Drinking Water Fact Sheet.The final PHG for hexavalent chromium, also known as chromium 6, is set at 0.02 parts per billion (ppb), which is the same level as the draft that was released for public comment in December 2010.“This final public health goal is the culmination of years of study and research on the health effects of this chemical,” said Dr. George Alexeeff, OEHHA’s Acting Director. “As the nation’s first official goal for this contaminant, it will be an important tool that the Department of Public Health will use to develop a regulatory standard that will protect Californians from the health risks of chromium 6 in drinking water.”

National Toxicology Program (NTP). 2008. NTP technical report on the toxicology and carcinogenesis studies of sodium dichromate dihydrate (CASRN 7789-12-0) in F344/N rats and B6C3F1 mice. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-546. https://ntp.niehs.nih.gov/go/tr546abs

This regulation establishes an exemption from the requirement of a tolerance for residues of carboxymethyl guar gum sodium salt (CAS Reg. No. 39346-76-4) and carboxy-methyl-hydroxy-propyl guar (CAS Reg. No. 68130-15-4); when used as an inert ingredient (thicker/drift reduction agent) in pesticide formulations applied to growing crops. SciReg Inc., on behalf of Rhodia Inc., submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment of an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of carboxymethyl guar gum sodium salt and carboxy-methyl-hydroxy-propyl guar.

National Toxicology Program (NTP). 1982. Carcinogenesis bioassay of guar gum (CASRN 9000-30-0) in F344 rats and B6C3F1 mice (feed study). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-229.
https://ntp.niehs.nih.gov/go/tr229abs

Bisphenol A (BPA) (Chemical Abstracts Service Registry Number (CASRN) 80-05-7), a high production volume (HPV) chemical, is a reproductive, developmental, and systemic toxicant in animal studies and is weakly estrogenic. EPA is providing this ANPRM to request comment on requiring toxicity testing to determine the potential for BPA to cause adverse effects, including endocrine-related effects, in environmental organisms at low concentrations. EPA is also seeking comment on requiring environmental testing consisting of sampling and monitoring for BPA in surface water, ground water, drinking water, soil, sediment, sludge, and landfill leachate in the vicinity of expected BPA releases to determine whether environmental organisms may currently be exposed to concentrations of BPA in the environment that are at or above levels of concern for adverse effects, including endocrine-related effects. This ANPRM is directed only toward the environmental presence and environmental effects of BPA. EPA is working with the Department of Health and Human Services (HHS) on potential human health issues, but is not considering any additional testing specifically in regard to human health issues at this time.

National Toxicology Program (NTP). 1982. Carcinogenesis bioassay of bisphenol A (CASRN 80-05-7) in F344 rats and B6C3F1 mice (feed study). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-215.
https://ntp.niehs.nih.gov/go/tr215abs

PHMSA amends the Hazardous Materials Regulations by removing saccharin and its salts from the list of hazardous substances and reportable quantities. The Comprehensive Environmental Response, Compensation and Liability Act, requires PHMSA to list and regulate all hazardous substances designated by statute or by the U.S. Environmental Protection Agency (EPA). EPA recently removed saccharin and its salts from their list of hazardous substances through notice and comment rulemaking. This final rule simply harmonizes the lists to better enable shippers and carriers to identify the affected hazardous substances, comply with all applicable regulatory requirements, and make required notifications if the release of a hazardous substance occurs.

National Toxicology Program (NTP). 2011. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

National Toxicology Program (NTP). 1999. NTP Report on Carcinogens background document for saccharin (CASRN 81-07-2). Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/saccharin1_3apps_508.pdf

This regulation establishes an exemption from the requirement of a tolerance for residues of Diethylene Glycol MonoEthyl Ether (DEGEE) when used as an inert ingredient as a solvent, stabilizer and/or antifreeze within pesticide formulations/products, for preharvest use on growing crops and raw agricultural commodities, without limitation. Huntsman, Dow AgroSciences L.L.C., Nufarm Americas Inc., BASF, Stepan Company, Loveland Products Inc., and Rhodia Inc. submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment of an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of DEGEE on growing crops and raw agricultural commodities.

National Toxicology Program (NTP). 1993. NTP technical report on the toxicology and carcinogenesis studies of ethylene glycol (CASRN 107-21-1) in B6C3F1 mice (feed studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-413.
https://ntp.niehs.nih.gov/go/tr413abs

The Food and Drug Administration (FDA) is issuing this document to address labeling and effectiveness testing for certain over-the-counter (OTC) sunscreen products containing specified active ingredients and marketed without approved applications. This document addresses labeling and effectiveness testing issues raised by the nearly 2,900 submissions that we received in response to the sunscreen proposed rule of August 27, 2007 (2007 proposed rule). The document also identifies specific claims that render a product that is subject to this rule misbranded or would not be allowed on any OTC sunscreen product marketed without an approved application. The document does not address issues related to sunscreen active ingredients or certain other issues regarding the GRASE determination for sunscreen products. The document requires OTC sunscreen products to comply with the content and format requirements for OTC drug labeling contained in the 1999 Drug Facts final rule (published in the Federal Register of March 17, 1999, by lifting the delay of implementation date for that rule that we published on September 3, 2004).

National Toxicology Program (NTP). 2011. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

This regulation establishes an exemption from the requirement of a tolerance for residues of ethylene glycol (CAS Reg. No. 107-21-1) when used as a pesticide inert ingredient as a solvent, stabilizer and/or antifreeze within pesticide formulations/products without limitation. Huntsman, et. al, submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting an establishment of an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of ethylene glycol. Also, this regulation establishes an exemption from the requirement of a tolerance for residues of ethylene glycol (CAS Reg. No. 107-21-1) when used as an inert ingredient as an encapsulating agent for pesticides being applied post-harvest as residual, and crack and crevice sprays in and around food and nonfood areas of residential and nonresidential structures, including food handling establishments, with no limit. The Sumitomo Chemical Company submitted a petition to EPA under FFDCA, requesting an establishment of an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of ethylene glycol.

National Toxicology Program (NTP). 1978. Bioassay of nitrofen (1836-75-5) for possible carcinogenicity. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-26
https://ntp.niehs.nih.gov/go/tr026abs

DoD is issuing a final rule amending the Defense Federal Acquisition Regulation Supplement (DFARS) to implement the requirements for minimizing the use of materials containing hexavalent chromium in items acquired by DoD (deliverables and construction materials hereafter referred to as deliverables). Hexavalent chromium is a chemical that has been used in numerous DoD weapons systems and platforms due to its corrosion protection properties. However, hexavalent chromium is a known carcinogen. This rule codifies a DoD policy for addressing the serious human health and environmental risks related to the use of hexavalent chromium. The rule prohibits the delivery of items containing more than 0.1 percent by weight hexavalent chromium in any homogeneous material under DoD contracts unless there is no acceptable alternative to the use of hexavalent chromium.

National Toxicology Program (NTP). 2011. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding four chemicals -- androstenedione (CAS No. 63-05-8), dibromoacetonitrile (CAS No. 3252-43-5), hexachlorobutadiene (CAS No. 87-68-3), and malonaldehyde, sodium salt (CAS No. 24382-04-5) -- to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 ). The listing of the four chemicals is effective May 3, 2011.

National Toxicology Program (NTP). 1988. NTP technical report on the toxicology and carcinogenesis studies of malonaldehyde, sodium salt (3-hydroxy-2-propenal, sodium salt) (CASRN 24382-04-5) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-331.
https://ntp.niehs.nih.gov/go/tr331abs

National Toxicology Program (NTP). 2010. NTP technical report on the toxicology and carcinogenesis studies of androstenedione (CASRN 63-05-8) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-560.
https://ntp.niehs.nih.gov/go/tr560abs

National Toxicology Program (NTP). 2010. NTP technical report on the toxicology and carcinogenesis studies of dibromoacetonitrile (CASRN 3252-43-5) in F344/N rats and B6C3F1 mice (drinking water studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-544.
https://ntp.niehs.nih.gov/go/tr544abs

This regulation establishes an exemption from the requirement of a tolerance for residues of sodium ferric ethylenediaminetetraacetate (EDTA) in or on all food commodities when applied as a molluscicide and used in accordance with good agricultural practices. W. Neudorff GmbH KG submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of sodium ferric EDTA under the FFDCA.

National Toxicology Program (NTP). 1977. Bioassay of trisodium ethylenediaminetetraacetate trihydrate (EDTA) (CASRN 150-38-9) for possible carcinogenicity. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-011.
https://ntp.niehs.nih.gov/go/tr011abs

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding acrylamide (CAS No. 79-06-1) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of acrylamide is effective February 25, 2011. Acrylamide is being listed as a chemical known to the State of California to cause developmental and male reproductive toxicity.

National Toxicology Program (NTP). 2011. Report on Carcinogens, twelfth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

This regulation establishes an exemption from the requirement of a tolerance for residues of (S,S)-Ethylene-diamine Di-succinic Acid Tri-sodium Salt (CAS Reg. No. 178949–82–1) when used as an inert ingredient (sequestrant or chelating agent) in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest under EPA regulations. Innospec Limited submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment of an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of (S,S)-ethylenediamine disuccinic acid trisodium salt.

National Toxicology Program (NTP). 1977. Bioassay of trisodium ethylenediaminetetraacetate trihydrate (EDTA) (CASRN 150-38-9) for possible carcinogenicity. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-011.
https://ntp.niehs.nih.gov/go/tr011abs

4-Methylimidazole meets the criteria for listing as known to the State to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code Section 25249.5 et seq.), more commonly known as Proposition 65, via the authoritative bodies mechanism. The regulatory requirements for listing by this mechanism are set forth in Title

National Toxicology Program (NTP). 2007. NTP technical report on the toxicology and carcinogenesis of 4-methylimidazole (CASRN 822-36-6) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-535.
https://ntp.niehs.nih.gov/go/tr535abs

EPA is adding 16 chemicals to the list of toxic chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA) of 1986 and section 6607 of the Pollution Prevention Act of 1990 (PPA). These 16 chemicals have been classified by the National Toxicology Program in their Report on Carcinogens as “reasonably anticipated to be a human carcinogen.” EPA has determined that these 16 chemicals meet the EPCRA section 313(d)(2)(B) criteria because they can reasonably be anticipated to cause cancer in humans.

NTP (National Toxicology Program). 2005. 1-amino-2,4-dibromoanthraquinone. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/aminodibromoanthraquinone.pdf

NTP (National Toxicology Program). 2005. 2,2-bis(bromomethyl)-1,3-propanediol. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/bis_bromomethyl_propanediol.pdf

NTP (National Toxicology Program). 2005. Furan. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/furan.pdf

NTP (National Toxicology Program). 2005. Glycidol. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/glycidol.pdf

NTP (National Toxicology Program). 2005. Isoprene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/isoprene.pdf

NTP (National Toxicology Program). 2005. Methyleugenol. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/methyleugenol.pdf

NTP (National Toxicology Program). 2005. 1,6-dinitropyrene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitroarenes.pdf

NTP (National Toxicology Program). 2005. 1,8-dinitropyrene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitroarenes.pdf

NTP (National Toxicology Program). 2005. 6-nitrochrysene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitroarenes.pdf

NTP (National Toxicology Program). 2005. 4-nitropyrene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitroarenes.pdf

NTP (National Toxicology Program). 2005. o-Nitroanisole. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. ) https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitroanisole.pdf

NTP (National Toxicology Program). 2005. Nitromethane. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. )
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitromethane.pdf

NTP (National Toxicology Program). 2005. Phenolphthalein. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. )
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/phenolphthalein.pdf

NTP (National Toxicology Program). 2005. Tetrafluoroethylene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. )
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tetrafluoroethylene.pdf

NTP (National Toxicology Program). 2005. Tetranitromethane. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. )
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tetranitromethane.pdf

NTP (National Toxicology Program). 2005. Vinyl fluoride. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. )
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/vinylhalides.pdf

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the publication of the final technical support documents for the Public Health Goals (PHGs) for benzo(a)pyrene, methoxychlor, and TCDD (dioxin) in drinking water. The PHG for benzo(a)pyrene is established at 0.007 parts per billion (ppb), based on carcinogenic effects in rats and mice. The PHG for methoxychlor is established at 0.09 ppb, based on effects in male offspring of female mice treated with methoxychlor during pregnancy. The PHG for TCDD is established at 0.00005 parts per trillion (ppt), based on tumors in multiple sites in female rats.

National Toxicology Program (NTP). 1982. NTP technical report on the carcinogenesis bioassay of 2,3,7,8-tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6) in Swiss-Webster mice. Research Triangle Park, NC: National Toxicology Program. Technical Report 201. https://ntp.niehs.nih.gov/go/tr201abs

National Toxicology Program (NTP). 1982. NTP technical report on the carcinogenesis bioassay of 2,3,7,8-tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6) in Osborne-Mendel rats and B6C3F1 mice (gavage study). Research Triangle Park, NC: National Toxicology Program. Technical Report 209. https://ntp.niehs.nih.gov/go/tr209abs

After the proposed test rule for hazardous air pollutants was issued in 1996, EPA’s Office of Air and Radiation (OAR) and EPA's Office of Research and Development (ORD) informed the Office of Pollution Prevention and Toxics (OPPT) that they no longer support the need for a final rule. Additionally, OPPT has determined that the record does not address scientific information developed since the original proposal was issued in 1996. Therefore, OPPT is withdrawing this proposed test rule and removing it from the EPA Semi-Annual Regulatory Agenda.

Docket No. OPPTS-42187

National Toxicology Program (NTP). 1996. Management status report. Research Triangle Park, NC: National Toxicology Program.

EPA is finalizing several revisions to the Lead Renovation, Repair, and Painting Program (RRP) rule that published in the Federal Register on April 22, 2008. The RRP rule established accreditation, training, certification, and recordkeeping requirements as well as work practice standards on persons performing renovations for compensation in most pre-1978 housing and child-occupied facilities. In this document, EPA is eliminating the “opt-out” provision that currently exempts a renovation firm from the training and work practice requirements of the rule where the firm obtains a certification from the owner of a residence he or she occupies that no child under age 6 or pregnant women resides in the home and the home is not a child-occupied facility. EPA is also requiring renovation firms to provide a copy of the records demonstrating compliance with the training and work practice requirements of the RRP rule to the owner and, if different, the occupant of the building being renovated or the operator of the child-occupied facility. In addition, the rule makes minor changes to the certification, accreditation and state authorization requirements. This final rule is effective July 6, 2010.

National Toxicology Program (NTP). 2009. Lead and lead compounds. Report on Carcinogens, Eleventh Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

The Food and Drug Administration (FDA) announces the availability of five documents related to FDA’s continuing assessment of Bisphenol A (BPA) and solicits public comments on the four documents prepared by FDA’s Center for Food Safety and Applied Nutrition (CFSAN). These documents do not represent an agency opinion or position on BPA, on which an interim update was recently provided. (See https://www.fda.gov/NewsEvents/PublicHealthFocus/ucm064437.htm). Rather, these documents provide perspectives and opinions that are being considered by FDA as it continues its safety assessment of BPA. This action will enable FDA to consider comments from the public in its assessment of BPA for food contact applications.

National Toxicology Program (NTP). 2008. NTP-CERHR monograph on the potential human reproductive and developmental effects of bisphenol A. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding Bromochloroacetic acid (CAS No. 5589-96-8), Cumene (CAS No. 98-82-8) and Diclofop-methyl (CAS No. 51338-27-3) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 ). The listing of bromochloroacetic acid, cumene and diclofop-methyl is effective April 6, 2010.

National Toxicology Program (NTP). 2009. NTP technical report on the toxicology and carcinogenesis studies of cumene (CASRN 98-82-8) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 542. https://ntp.niehs.nih.gov/go/tr542abs

National Toxicology Program (NTP). 2009. NTP technical report on the toxicology and carcinogenesis studies of bromochloroacetic acid (CASRN 5589-96-8) in F344/N rats and B6C3F1 mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 549. https://ntp.niehs.nih.gov/go/tr549abs

Under the Clean Air Act Section 211(o), as amended by the Energy Independence and Security Act of 2007 (EISA), the Environmental Protection Agency is required to promulgate regulations implementing changes to the Renewable Fuel Standard program. The revised statutory requirements specify the volumes of cellulosic biofuel, biomass-based diesel, advanced biofuel, and total renewable fuel that must be used in transportation fuel. This action finalizes the regulations that implement the requirements of EISA, including the cellulosic, biomass-based diesel, advanced biofuel, and renewable fuel standards that will apply to all gasoline and diesel produced or imported in 2010.

National Toxicology Program (NTP). 2009. Report on carcinogens, eleventh edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

In response to two petitions seeking disclosure of selected inert ingredients on pesticide labels, based on hazard, EPA is initiating rulemaking to increase public availability of the identities of the inert ingredients in pesticide products. This action would assist consumers and users of pesticides in making informed decisions and reduce the presence of potentially hazardous ingredients in pesticides.

National Toxicology Program (NTP). 2009. Report on carcinogens, eleventh edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is announcing the availability of the final technical support document for the Public Health Goal (PHG) for the solvent 1,2,3-trichloropropane in drinking water. This document establishes a PHG for 1,2,3-trichloropropane of 0.0007 parts per billion, versus the current Notification Level of 0.005 ppb, set in 2005. The PHG is based on an updated cancer potency calculation.

National Toxicology Program (NTP). 1982. Carcinogenesis bioassay of 1,2-dibromo-3-chloropropane (CASRN 96-12-8) in F344/N rats and B6C3F1 mice (inhalation studies). TR-206.
https://ntp.niehs.nih.gov/go/tr206abs

National Toxicology Program (NTP). 1993. NTP technical report on the toxicology and carcinogenesis of 1,2,3-trichloropropane (CASRN 96-18-4) in F344/N rats and B6C3F1 mice (gavage studies). TR-384.
https://ntp.niehs.nih.gov/go/tr384abs 

National Toxicology Program (NTP). 2009. Report on carcinogens, eleventh edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

This regulation establishes an exemption from the requirement of a tolerance for residues of amine salts of alkyl (C8-C24) benzenesulfonic acid (dimethylaminopropylamine, isopropylamine, mono-, di-, and triethanolamine) when used as an inert ingredient in pesticide formulations applied to growing crops and applied to animals. The Joint Inerts Task Force, Cluster Support Team Number 8, submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of amine salts of alkyl (C8-C24) benzenesulfonic acid (dimethyl aminopropylamine, isopropylamine, mono-, di, and triethanolamine).

National Toxicology Program (NTP). 1992. NTP technical report on the toxicology and carcinogenesis studies of diethanolamine (CASRN 111-42-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-478.
https://cebs.niehs.nih.gov/cebs/publication/TR-478

OEHHA within the California Environmental Protection Agency is announcing the availability of the final technical support document for the Public Health Goal (PHG) for the solvent tri-chloro-ethyl-ene in drinking water. This document increases the PHG for tri-chloro-ethyl-ene to 1.7 parts per billion, versus 0.8 ppb in the original PHG published in 1999. The PHG is based on the same cancer endpoint with an updated potency calculation.

National Toxicology Program (NTP). 1988. NTP technical report on the toxicology and carcinogenesis studies of trichloroethyl­ene (CAS No. 79-01-6) in four strains of rats (ACI, August, Marshall, Osborne-Mendel) (gavage studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-273. 
https://ntp.niehs.nih.gov/go/tr273abs

National Toxicology Program (NTP). 1990. Carcinogenesis studies of trichloroethylene (without epichlorohydrin) (CASRN 79-01-6) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-243.
https://ntp.niehs.nih.gov/go/tr243abs

This regulation amends the exemption from the requirement of a tolerance for residues of silver (excludes silver salts) in or on all foods when applied or used in public eating places, dairy processing equipment, and food processing equipment. ETO H2O, Inc., submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act requesting to establish concentration limits for silver in end-use solutions eligible for tolerance exemption. The regulation being established will exempt all foods from the requirement of a tolerance for residues of silver resulting from contact with surfaces treated with solutions in which the end-use concentration of silver is not to exceed 50 parts per million (ppm).

National Toxicology Program (NTP). 2002. Developmental toxicity evaluation for silver acetate (CASRN 563-63-3) administered by gavage to Sprague-Dawley rats on gestational days 6-19. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TER20001.
https://ntp.niehs.nih.gov/go/ter20001abs

A revised Public Health Goal (PHG) of 0.3 parts per billion (ppb) is hereby established for pentachlorophenol (PCP) in drinking water, based on carcinogenicity. The earlier PHG for PCP of 0.4 ppb, developed in 1997, is based on the same rodent carcinogenicity data and a cancer potency value identical to that used in this revised PHG.

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of two pentachlorophenol (CASRN 87-86-5) technical-grade mixtures in B6C3F1 mice (feed studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-349.
https://ntp.niehs.nih.gov/go/tr349abs

National Toxicology Program (NTP). 1999. NTP technical report on the toxicology and carcinogenesis studies of pentachlorophenol (CASRN 87-86-5) in F344/N rats (feed studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-483.
https://ntp.niehs.nih.gov/go/tr483abs

National Toxicology Program (NTP). 2009. Report on carcinogens, eleventh edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

This regulation establishes time-limited tolerances for combined residues of diflubenzuron and its metabolites p-chlorophenylurea and p-chloroaniline in or on alfalfa, forage and alfalfa, hay. This action is in response to EPAs granting of an emergency exemption under section 18 of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) authorizing use of the pesticide on alfalfa and mixed grass/alfalfa fields. This regulation establishes a maximum permissible level for residues of diflubenzuron and its metabolites p-chlorophenylurea and p-chloroaniline, in these food commodities. The time-limited tolerances expire and are revoked on December 31, 2011.

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of para-chloroaniline hydrochloride (CASRN 20265-96-7) in F344/N rats and B6C3F1 mice (gavage studies).  Research Triangle Park, NC: National Toxicology Program. Technical Report 351. https://ntp.niehs.nih.gov/go/tr351abs

This regulation establishes an exemption from the requirement of a tolerance for residues of (S,S)-Ethylene-di-amine-di-succinic Acid (CAS Reg. No. 20846-91-7) ((S,S)EDDS) when used as an inert ingredient sequestrant or chelating agent in pesticide formulations applied to growing crops only under 40 CFR 180.920. Associated Octel Company, Limited, submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), as amended by the Food Quality Protection Act of 1996 (FQPA), requesting an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of (S,S)Ethylenediaminedisuccinic acid.

National Cancer Institute (NCI). 1977. NCI technical report on the bioassay of trisodium ethylen ediaminetetraacetate trihydrate (EDTA) for possible carcinogenicity. Bethesda, MA: National Cancer Institute. Technical Report 011. https://ntp.niehs.nih.gov/go/tr011abs

Based on its review of the air quality criteria and national ambient air quality standards (NAAQS) for lead (Pb), EPA is making revisions to the primary and secondary NAAQS for Pb to provide requisite protection of public health and welfare, respectively. With regard to the primary standard, EPA is revising the level to 0.15 μg/m3. EPA is retaining the current indicator of Pb in total suspended particles (Pb-TSP). EPA is revising the averaging time to a rolling 3-month period with a maximum (not-to-be-exceeded) form, evaluated over a 3-year period. EPA is revising the secondary standard to be identical in all respects to the revised primary standard.

NTP (National Toxicology Program). 2005. Lead and lead compounds. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/lead.pdf

The ATSDR toxicological profile succinctly characterizes the toxicology and adverse health effects information for the toxic substance. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicological properties.

NTP (National Toxicology Program). 2005. Report on carcinogens, eleventh edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

NTP (National Toxicology Program). 2005. Cadmium and cadmium compounds. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cadmium.pdf

NTP (National Toxicology Program). 2005. Chromium hexavalent compounds. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chromiumhexavalentcompounds.pdf

The Toxic Substances Control Act (TSCA) Interagency Testing Committee (ITC) transmitted its 63rd Report to the Administrator of the EPA on October 7, 2008. In the 63rd ITC report, which is included with this notice, the ITC is revising the TSCA section 4(e) Priority Testing List by removing 1 tungsten compound and 1 High Production Volume (HPV) Challenge Program orphan chemical.

National Toxicology Program December 9-10, 2008 Report on carcinogens (RoC) expert panel meeting: cobalt-tungsten carbide powders and hard metals. https://ntp.niehs.nih.gov/go/849588 [accessed 12 July 2022]

We are setting emission standards for new non-road spark-ignition engines that will substantially reduce emissions from these engines. The exhaust emission standards apply starting in 2010 for new marine spark-ignition engines, including first-time EPA standards for stern-drive and inboard engines. The exhaust emission standards apply starting in 2011 and 2012 for different sizes of new land-based, spark-ignition engines at or below 19 kilowatts (kW). These small engines are used primarily in lawn and garden applications. We are also adopting evaporative emission standards for vessels and equipment using any of these engines. In addition, we are making other minor amendments to our regulations.

NTP (National Toxicology Program). 2005. 1,3-butadiene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/butadiene.pdf

NTP (National Toxicology Program). 2005. Acetaldehyde. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acetaldehyde.pdf

NTP (National Toxicology Program). 2005. Naphthalene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/naphthalene.pdf

In this order, EPA denies objections to, and requests for hearing on, a prior order denying a petition requesting that EPA revoke all pesticide tolerances for dichlorvos under section 408(d) of the Federal Food, Drug, and Cosmetic Act. The objections and hearing requests were filed on February 1, 2008, by the Natural Resources Defense Council (NRDC). The Original petition was also filed by NRDC.

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of dichlorvos (CASRN 62-73-7) in F344/N rats and B6C3F1 mice (gavage studies).  Research Triangle Park, NC: National Toxicology Program. Technical Report 342. https://ntp.niehs.nih.gov/go/tr342abs

EPA is adopting a comprehensive program to dramatically reduce pollution from locomotives and marine diesel engines. The controls will apply to all types of locomotives, including line-haul, switch, and passenger, and all types of marine diesel engines below 30 liters per cylinder displacement, including commercial and recreational, propulsion and auxiliary. The near-term emission standards for newly-built engines will phase in starting in 2009. The near-term program also includes new emission limits for existing locomotives and marine diesel engines that apply when they are remanufactured, and take effect as soon as certified remanufacture systems are available, as early as 2008. The long-term emissions standards for newly-built locomotives and marine diesel engines are based on the application of high-efficiency catalytic after-treatment technology. These standards begin to take effect in 2015 for locomotives and in 2014 for marine diesel engines. We estimate particulate matter (PM) reductions of 90 percent and nitrogen oxides (NOX) reductions of 80 percent from engines meeting these standards, compared to engines meeting the current standards.

NTP (National Toxicology Program). 2005. Naphthalene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/naphthalene.pdf

NTP (National Toxicology Program). 2005. Benzene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/benzene.pdf

NTP (National Toxicology Program). 2005. 1,3-butadiene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/butadiene.pdf

NTP (National Toxicology Program). 2005. Acetaldehyde. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acetaldehyde.pdf

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding dibromoacetic acid (CAS No. 631-64-1) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., commonly known as Proposition 65). The listing of dibromoacetic acid is effective June 17, 2008. Toxicological endpoints: Reproductive Toxicity and Cancer

National Toxicology Program (NTP). 2007. NTP technical report on the toxicology and carcinogenesis studies of dibromoacetic acid (CASRN 631-64-1) in F344/N rats and B6C3F1 mice (drinking water studies).  Research Triangle Park, NC: National Toxicology Program. Technical Report 537. https://ntp.niehs.nih.gov/go/tr537abs

The Toxic Substances Control Act (TSCA) Interagency Testing Committee (ITC) transmitted its sixty-second report to the Administrator of EPA on April 17, 2008. In the 62nd ITC Report, which is included with this notice, the ITC is revising the TSCA section 4(e) Priority Testing List by removing four tungsten compounds and four cresols.

National Toxicology Program December 9-10, 2008 report on carcinogens (RoC) expert panel meeting: cobalt-tungsten carbide powders and hard metals. https://ntp.niehs.nih.gov/go/849588 [accessed 12 July 2022]

This Public Health Goal (PHG) technical support document provides information on health effects from copper in drinking water. PHGs are developed for chemical contaminants based on the best available toxicological data in the scientific literature. These documents and the analyses contained in them provide estimates of the levels of contaminants in drinking water that would pose no significant health risk to individuals consuming the water on a daily basis over a lifetime.

National Toxicology Program (NTP). 1993. NTP technical report on the toxicity studies of cupric sulfate (CASRN 7758-99-8) administered in drinking water and feed to F344/N rats and B6C3F1 mice. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 29. https://ntp.niehs.nih.gov/go/tox29abs

This Public Health Goal (PHG) technical support document provides information on health effects from Water Soluble Polychlorinated Biphenyls Expected to be Found in Drinking Water. PHGs are developed for chemical contaminants based on the best available toxicological data in the scientific literature. These documents and the analyses contained in them provide estimates of the levels of contaminants in drinking water that would pose no significant health risk to individuals consuming the water on a daily basis over a lifetime.

NTP (National Toxicology Program). 2000. Report on carcinogens, ninth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding anthraquinone (CAS No. 84-65-1) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., commonly known as Proposition 65). The listing of anthraquinone is effective September 28, 2007. Anthraquinone (CAS No. 84-65-1) is being listed as a chemical known to the State of California to cause cancer. The listing of this chemical is based on formal identification by an authoritative body (i.e., the National Toxicology Program (NTP)), that the chemical causes cancer. The criteria used by OEHHA for the listing of chemicals under the authoritative bodies mechanism can be found in Title 22, Cal. Code of Regs., section 12306. Toxicological endpoint: cancer.

National Toxicology Program (NTP). 2005. NTP technical report on the toxicology and carcinogenesis studies of anthraquinone (CASRN 84-65-1) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 494. https://ntp.niehs.nih.gov/go/tr494abs

NTP (National Toxicology Program). 2005. Anthraquinone. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/aminoanthraquinone.pdf

This notice announces the intent of ATSDR to develop two interaction profiles.

National Toxicology Program (NTP). 1999. NTP report on carcinogens background document for 2,3, 7,8-tetrachlorodibenzo-p-dioxin (TCDD). Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/tetrachl_tcdd_4apps_508.pdf

National Toxicology Program (NTP). 1979. NTP technical report on the toxicology and carcinogenesis studies of 2,2N,4,4N,5,5N-hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) in female Harlan Sprague-Dawley rats (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 529. https://ntp.niehs.nih.gov/go/tr529abs

National Cancer Institute (NCI). 1979. NCI technical report on the bioassay of fenthion (CASRN 55-38-9) for possible carcinogenicity. Bethesda, MA: National Cancer Institute. Technical Report 103. https://ntp.niehs.nih.gov/go/tr103abs

National Cancer Institute (NCI). 1979. NCI technical report on the bioassay of malathion (CASRN 121-75-5) for possible carcinogenicity. Bethesda, MA: National Cancer Institute. Technical Report 192. https://ntp.niehs.nih.gov/go/tr192abs

National Cancer Institute (NCI). 1978. NCI technical report on the bioassay of aroclor 1254 (CASRN 27323-18-8) for possible carcinogenicity. Bethesda, MA: National Cancer Institute. Technical Report 38. https://ntp.niehs.nih.gov/go/tr38abs

National Cancer Institute (NCI). 1979. NCI technical report on the bioassay of dibenzo p-dioxin (CASRN 262-12-4) for possible carcinogenicity. Bethesda, MA: National Cancer Institute. Technical Report 122. https://ntp.niehs.nih.gov/go/tr122abs

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-n-butyl phthalate (DBP). Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dbp/dbp_monograph_final.pdf

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-isononyl phthalate (DINP). Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dinp/dinp_monograph_final.pdf

National Toxicology Program (NTP). 2006. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-(2-ethylhexyl) phthalate. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dehp/dehp-monograph.pdf

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-n-hexyl phthalate. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dnhp/dnhp_monograph_final.pdf

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-isodecyl phthalate. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/didp/didp_monograph_final.pdf

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-n-octyl phthalate. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dnop/dnop_monograph_final.pdf

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the publication of the final Public Health Goals (PHGs) for glyphosate, which is an update of the PHG published in 1997.

National Toxicology Program (NTP). 1992. NTP technical report on the toxicity studies of glyphosate (CASRN 1071-83-6) administered in dose feed to F344/N rats and B6C3F1 mice. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 16. https://ntp.niehs.nih.gov/go/tox16abs

The Environmental Protection Agency (EPA) determines that n-propyl bromide (nPB) is an acceptable substitute for methyl chloroform and chlorofluorocarbon (CFC)-113 in the solvent cleaning sector under the Significant New Alternatives Policy (SNAP) program under section 612 of the Clean Air Act. The SNAP program reviews alternatives to Class I and Class II ozone depleting substances and approves use of alternatives which do not present a substantially greater risk to public health and the environment than the substance they replace or than other available substitutes.

NTP, 2003. Results of 13-week inhalation testing by the National Toxicology Program. https://ntp.niehs.nih.gov/go/717271

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of 1-bromopropane. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/bromopropanes/1-bromopropane/1bp_monograph.pdf

EPA published a proposed test rule under section 4 of the Toxics Substances and Control Act (TSCA) in 1992 covering a number of aryl phosphate base stocks. On March 30, 1993, EPA announced initiation of negotiations with the Aryl Phosphates Panel of the Chemical Manufacturers Association (now the American Chemistry Council or ACC) to develop a TSCA Section 4 Enforceable Consent Agreement (ECA) for aryl phosphate base stocks as an alternative approach to testing under the proposed rule (58 FR 16669). On October 9, 1998, EPA sent letters to the Chief Executive Officers of companies, including those who were participating in the development of this ECA, to announce EPA's High Production Volume (HPV) Challenge Program.

EPA is evaluating the need for any additional testing of the subject aryl phosphate base stocks under an ECA or rulemaking.

Docket No. RIN: 2070-Ab07

National Toxicology Program (NTP). 1994. NTP technical report on toxicology and carcinogenesis studies of tricresyl phosphate in F344/N rats and B6C3F1 mice (gavage and feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 433. https://ntp.niehs.nih.gov/go/tr433abs

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding di-isodecyl phthalate (DIDP) (CAS No. 68515-49-1 and 26761-40-0) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., commonly known as Proposition 65). The listing of di-isodecyl phthalate (DIDP) is effective April 20, 2007.

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-isodecyl phthalate (DIDP). Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/didp/didp_monograph_final.pdf

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the publication of the final Public Health Goals (PHGs) for N-nitrosodimethylamine and cadmium.

National Toxicology Program (NTP). 1999. Report on carcinogens, ninth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is removing isosafrole [CAS No. 120-58-1], 5-nitro-o-anisidine [CAS No. 99-59-2], and tris(aziridinyl)-p-benzoquinone (triaziquone) [CAS No. 68-76-8] from the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The delisting of the three chemicals is effective December 8, 2006. 5-Nitro-o-anisidine was removed from the NTP Sixth Annual Report on Carcinogens as a substance reasonably anticipated to be a human carcinogen in 1991, when NTP concluded there was insufficient evidence of carcinogenicity.

National Toxicology Program (NTP). 2004. Report on carcinogens, eleventh edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

This regulation establishes tolerances for combined residues of diflubenzuron and its metabolites 4-chlorophenylurea and 4-chloroaniline in or on brassica, leafy greens subgroup 5B, turnip greens, peanut, peanut hay, peanut oil, barley grain, barley hay, barley straw, oat grain, oat forage, oat hay, oat straw, wheat grain, wheat forage, wheat hay, wheat straw, aspirated grain fractions, and pummelo. The Interregional Research Project #4 requested these tolerances under the Federal Food, Drug, and Cosmetic Act (FFDCA), as amended by the Food Quality Protection Act of 1996 (FQPA).

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of para-chloroaniline hydrochloride (CASRN 20265-96-7) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-351.
https://ntp.niehs.nih.gov/go/tr351abs

EPA is promulgating amendments to the Toxic Substances Control Act (TSCA) section 12(b) export notification regulations at subpart D of 40 CFR part 707. One amendment changes the current annual notification requirement to a one-time requirement for exporters of chemical substances or mixtures (hereinafter referred to as \"chemicals\") for which certain actions have been taken under TSCA. Relatedly, for the same TSCA actions, EPA is changing the current requirement that the Agency notify foreign governments annually after the Agency's receipt of export notifications from exporters to a requirement that the Agency notify foreign governments once after it receives the first export notification from an exporter. EPA is also promulgating de minimis concentration levels below which notification will not be required for the export of any chemical for which export notification under TSCA section 12(b) is otherwise required, promulgating other minor amendments (to update the EPA addresses to which export notifications must be sent, to indicate that a single export notification may refer to more than one section of TSCA where the exported chemical is the subject of multiple TSCA actions, and to correct an error in 40 CFR 799.19 that currently omits mentioning multi-chemical test rules as being among those final TSCA section 4 actions that trigger export notification), and clarifying exporters' and EPA's obligations where an export notification- triggering action is taken with respect to a chemical previously or currently subject to export notification due to the existence of a previous triggering action.

National Toxicology Program (NTP). 2004. Report on carcinogens, eleventh edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

This regulation establishes an exemption from the requirement of a tolerance for residues of eucalyptus oil on honey and honeycomb when applied at 2 g or less eucalyptus oil per hive to suppress varroa mites. Brushy Mountain Bee farm, c/o IR-4 Project submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), as amended by the Food Quality Protection Act of 1996 (FQPA), requesting an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of eucalyptus oil in honey and honeycomb.

National Toxicology Program (NTP). 1,8-cineole (470-82-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. Accessed 2022-07-27.
https://doi.org/10.22427/NTP-DATA-DTXSID4020616

The Food and Drug Administration is issuing a notice of proposed rulemaking that would establish that over-the-counter (OTC) skin bleaching drug products are not generally recognized as safe and effective (GRASE) and are misbranded. FDA is also withdrawing the previous proposed rule on skin bleaching drug products for OTC human use, which was issued in the form of a tentative final monograph (TFM). FDA is issuing this proposed rule after considering new data and information on the safety of hydroquinone, the only active ingredient that had been proposed for inclusion in a monograph for these products. This proposal is part of FDA's ongoing review of OTC drug products. Further, upon issuance of a final rule, FDA intends to consider all skin bleaching drug products, whether currently marketed on a prescription or OTC basis, to be new drugs requiring an approved new drug application (NDA) for continued marketing.

National Toxicology Program (NTP). 1989. NTP technical report of the toxicology and carcinogenesis studies of hydroquinone in F344/N rats and B6C3F1 mice (gavage studies).  Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-366.
https://ntp.niehs.nih.gov/go/tr366abs

EPA is proposing revised standards to limit emissions ofperchloroethylene (PCE) from existing and new dry cleaning facilities.

National Toxicology Program (NTP). 1986. NTP technical report on the toxicology and carcinogenesis studies of tetrachloroethylene (perchloroethylene) (CASRN 127-18-4) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 311. https://ntp.niehs.nih.gov/go/tr311abs

This final rule revises the May 20, 2006 effective date of the diesel particulate matter (DPM) final concentration limit of 160 micrograms of total carbon (TC) per cubic meter of air (160TC ug/m3) promulgated in the 2001 final rule \"Diesel Particulate Matter Exposure of Underground Metal and Nonmetal Miners,\" and published in the Federal Register on January 19, 2001 (66 FR 5706) and amended on September 19, 2005 (70 FR 55019).

National Toxicology Program (NTP). 2002. Report on carcinogens, tenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

This action finalizes our decision not to revise the Ethylene Oxide Emission Standards for Sterilization Facilities, originally promulgated on December 6, 1994. Within 8 years of promulgating these standards, the Clean Air Act directs us to assess the risk and to promulgate more stringent standards if necessary to protect public health with an ample margin of safety and to prevent adverse environmental effects. Also, within 8 years of promulgating the national emission standards, the Clean Air Act requires us to review and revise the standards as necessary, taking into account developments in practices, processes, and control technologies. Today¿s action reflects our findings that after conducting these risk and technology reviews, no additional control requirements are warranted.

National Toxicology Program (NTP). 2002. Report on carcinogens, tenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

EPA is promulgating a final rule under the Toxic Substances Control Act that requires manufacturers (including importers) and processors of 17 high production volume chemicals to conduct acute toxicity, repeat dose toxicity, developmental and reproductive toxicity, genetic toxicity (gene mutations and chromosomal aberrations), ecotoxicity (in fish, Daphnia, and algae), and environmental fate (including 5 tests for physical chemical properties and biodegradation) testing.

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of pentaerythritol tetranitrate (CASRN 78-11-5) with 80% d-lactose monohydrate (PETN, NF) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-365.
https://ntp.niehs.nih.gov/go/tr365abs

In accordance with Health and Safety Code Section 116293 (SB1822, Sher, Statutes of 2002), the Office of Environmental Health Hazard Assessment (OEHHA) hereby publishes the final Public Health Goal (PHG) for cis/trans-1,2-dichloroethylene, 1,1,1-trichloroethane, 1,1,2-trichloroethane, radium-226 and 228, strontium-90, and tritium in drinking water. OEHHA has completed technical support documents that provide the scientific basis for the PHGs.

National Toxicology Program (NTP). 2002. NTP technical report on the toxicity studies of trans-1,2-dichloroethylene (CASRN 156-60-5) administered in microcapsules in feed to F344/N rats and B6C3F1 mice. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TOX-55.
https://ntp.niehs.nih.gov/go/tox55abs

National Toxicology Program (NTP). 1987. Developmental toxicity evaluation of 1,1,1-trichloroethane (CASRN 71-55-6) administered to CD rats. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. T0151.
https://ntp.niehs.nih.gov/go/t0151abs

National Toxicology Program (NTP). 1987. Developmental toxicity evaluation of 1,1,1-trichloroethane administered in drinking water to CD rats. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. T0179.
https://ntp.niehs.nih.gov/go/t0179abs

National Toxicology Program (NTP). 1996. NTP technical report on renal toxicity studies of selected halogenated ethanes to F344/N rats (gavage studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TOX-45.
https://ntp.niehs.nih.gov/go/tox45abs

National Toxicology Program (NTP). 2000. ntp technical report on the toxicity studies of 1,1,1-trichloroethane (CASRN 71-55-6) administered in microcapsules in feed to F344/N rats and B6C3F1 mice. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TOX-41.
https://ntp.niehs.nih.gov/go/tox41abs

The Occupational Safety and Health Administration (OSHA) is amending the existing standard which limits occupational exposure to hexavalent chromium (Cr(VI)). OSHA has determined based upon the best evidence currently available that at the current permissible exposure limit (PEL) for Cr(VI), workers face a significant risk to material impairment of their health.

National Toxicology Program (NTP). 1980. Report on carcinogens, first edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://ntp.niehs.nih.gov/go/roc

NTP (National Toxicology Program). 1980. Chromium hexavalent compounds. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chromiumhexavalentcompounds.pdf

National Toxicology Program (NTP). 1997. Reproductive toxicity of potassium dichromate (hexavalent) (CASRN 7778-50-9) administered in diet to BALB/c mice. Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/racb94014abs

National Toxicology Program (NTP). 1996. reproductive toxicity (testicular) of potassium dichromate (hexavalent) (CASRN 7778-50-9) administered in diet to BALB/c Mice. https://ntp.niehs.nih.gov/go/racb95002abs

National Toxicology Program (NTP). 1996. reproductive toxicity of potassium dichromate (hexavalent) (CASRN 7778-50-9) administered in diet to SD rats. https://ntp.niehs.nih.gov/go/racb95001abs

The Environmental Protection Agency (EPA) is promulgating today's final rule, the Stage 2 Disinfectants and Disinfection Byproducts Rule (DBPR), to provide for increased protection against the potential risks for cancer and reproductive and developmental health effects associated with disinfection byproducts (DBPs).

National Toxicology Program (NTP). 1987. NTP technical report on the toxicology and carcinogenesis studies of bromodichloromethane (CASRN 75-27-4) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-321. https://ntp.niehs.nih.gov/go/tr321abs

National Toxicology Program (NTP). 2004. NTP technical report on the toxicology and carcinogenesis studies of sodium chlorate (CASRN 7775-09-9) in F344/N rats and B6C3F1 mice (drinking water studies)—draft abstract. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-517. https://ntp.niehs.nih.gov/go/tr517abs

National Toxicology Program (NTP). 2005. NTP technical report on the toxicology and carcinogenesis studies of bromodichloromethane (CASRN 75-27-4) in male F344/N rats and female B6C3F1 mice (drinking water studies)—draft abstract. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. TR-532. https://ntp.niehs.nih.gov/go/tr532abs

National Toxicology Program (NTP). 2005. Dibromoacetic acid (631-64-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
https://cebs.niehs.nih.gov/cebs/test_article/631-64-1

EPA is amending the list of hazardous air pollutants contained in section 112 of the Clean Air Act by removing the compound methyl ethyl ketone (MEK) (2-Butanone) (CAS No. 78-93-3). This action is being taken in response to a petition submitted by the Ketones Panel of the American Chemistry Council (formerly the Chemical Manufacturers Association) on behalf of MEK producers and consumers to delete MEK from the HAP list. Petitions to remove a substance from the HAP list are permitted under section 112 of the CAA.

National Toxicology Program (NTP). 1990. Inhalation developmental toxicology studies: teratology study of methyl ethyl ketone (CASRN 78-93-3) in mice. NTP Study TER88046. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/go/ter88046abs

National Toxicology Program (NTP). 2007. NTP technical report on the toxicology and carcinogenesis studies of methyl isobutyl ketone (CASRN 108-10-1) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 538. https://ntp.niehs.nih.gov/go/tr538abs

The Food and Drug Administration (FDA) is amending the food additive regulations to provide for the safe use of n-octanol (n-octyl alcohol) produced by a new manufacturing process, the hydrodimerization of 1,3-butadiene. This action is in response to a petition filed by Kuraray International Corp.

National Toxicology Program (NTP). 1993. NTP technical report on the toxicology and carcinogenesis studies of 1,3-butadiene (CASRN 106-99-0) in B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 434. https://ntp.niehs.nih.gov/go/tr434abs

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding butyl benzyl phthalate (BBP) (CAS No. 85 68-7), di-n-butyl phthalate (DBP) (CAS No. 84-74-2), and di-n-hexyl phthalate (DnHP) (CAS No. 84-75-3) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., commonly known as Proposition 65). The listing of the three phthalates is effective December 2, 2005 Toxicological endpoint: cancer. Toxicological endpoints: Developmental toxicity, Female reproductive toxicity, and Male reproductive toxicity.

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of butyl benzyl phthalate. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/bb-phthalate/bbp_monograph_final.pdf

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-n-butyl phthalate (DBP). Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dbp/dbp_monograph_final.pdf

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of di-n-hexyl phthalate (DnHP). Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/phthalates/dnhp/dnhp_monograph_final.pdf

This action finalizes national emission standards (NESHAP) for hazardous air pollutants for hazardous waste combustors (HWCs): hazardous waste burning incinerators, cement kilns, lightweight aggregate kilns, industrial/commercial/institutional boilers and process heaters, and hydrochloric acid production furnaces. EPA has identified HWCs as major sources of hazardous air pollutant (HAP) emissions.

National Toxicology Program (NTP). 1996. NTP technical report on the toxicology and carcinogenesis studies of nickel oxide (CASRN 1313-99-1) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 451. https://ntp.niehs.nih.gov/go/tr451abs

National Toxicology Program (NTP). 1996. NTP technical report on the toxicology and carcinogenesis studies of nickel subsulfide (CASRN 12035-72-2) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 453. https://ntp.niehs.nih.gov/go/tr453abs

National Toxicology Program (NTP). 1996. NTP technical report on the toxicology and carcinogenesis studies of nickel sulfate hexahydrate (CASRN 10101-97-0) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 454. https://ntp.niehs.nih.gov/go/tr454abs

NTP (National Toxicology Program). 2002. Nickel compounds and metallic nickel. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nickel.pdf

NTP (National Toxicology Program). 2000. 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tetrachlorodibenzodioxin.pdf

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding estrogens, steroidal to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of estrogens, steroidal is effective August 19, 2005.

NTP (National Toxicology Program). 2002. Report on carcinogens, tenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

In this final rule: MSHA revises the existing standards addressing diesel particulate matter (DPM) exposure in underground metal and nonmetal (M/NM) mines; changes the interim concentration limit measured by total carbon to a comparable permissible exposure limit measured by elemental carbon, which renders a more accurate DPM exposure measurement; increases flexibility of compliance for mine operators by requiring longstanding hierarchy of controls for its other exposure-based health standards at M/NM mines, but retains the prohibition on rotation of miners for compliance; requires MSHA to consider economic as well as technological feasibility in determining if operators qualify for an extension of time in which to meet the final DPM limit; deletes the requirement for a control plan; and makes conforming changes to existing provisions concerning compliance determinations, environmental monitoring and recordkeeping.

NTP (National Toxicology Program). 2002. Report on carcinogens, tenth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

NTP (National Toxicology Program). 2002. Diesel exhaust particulates. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dieselexhaustparticulates.pdf

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding cobalt sulfate (CAS No. 10124-43-3) and diazoaminobenzene (CAS No. 136-35-6) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of cobalt sulfate and diazoaminobenzene is effective May 20, 2005. Toxicological Endpoint: cancer

NTP (National Toxicology Program). 2005. Diazoaminobenzene. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/diazoaminobenzene.pdf

NTP (National Toxicology Program). 2005. Report on carcinogens, eleventh edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

This notice announces the initial filing of a pesticide petition proposing the establishment of regulations for residues of a certain pesticide chemical in or on various food commodities.

National Toxicology Program (NTP). 1986. NTP technical report on the toxicology and carcinogenesis studies of isophorone (CASRN 78-59-1) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 291. https://ntp.niehs.nih.gov/go/tr291abs

The Occupational Safety and Health Administration (OSHA) has conducted a review of its Ethylene Oxide (EtO) Standard pursuant to section 610 of the Regulatory Flexibility Act and section 5 of Executive Order 12866 on Regulatory Planning and Review.

National Toxicology Program (NTP). 1987. NTP technical report on the toxicology and carcinogenesis studies of ethylene oxide (CASRN 75-21-8) in B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 326. https://ntp.niehs.nih.gov/go/tr326abs

The Food and Drug Administration (FDA) is amending the food additive regulations to provide for the safe use of acacia (gum arabic) as a thickener, emulsifier, or stabilizer in alcoholic beverages at a maximum use level of 20 percent. This action is in response to a petition filed by Kerry, Inc.

National Toxicology Program (NTP). 1982. NTP technical report on the carcinogenesis bioassay of gum arabic (CASRN 9000-01-5) in F344 rats and B6C3F1 mice (feed study). Research Triangle Park, NC: National Toxicology Program. Technical Report 227. https://ntp.niehs.nih.gov/go/tr227abs

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding vanadium pentoxide (orthorhombic crystalline form) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., Proposition 65). The listing of the chemical is effective February 11, 2005.Toxicological Endpoint: Cancer

National Toxicology Program (NTP). 2002. NTP technical report on the toxicology and carcinogenesis studies of vanadium pentoxide (CASRN 1314-62-1) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 507. https://ntp.niehs.nih.gov/go/tr507abs

The Food and Drug Administration (FDA) is announcing the availability of a guidance document entitled \"Guidance for Industry: Labeling for Topically Applied Cosmetic Products Containing Alpha Hydroxy Acids as Ingredients.\" The guidance recommends content for a labeling statement for cosmetic products containing alpha hydroxy acids (AHAs) as ingredients.

National Toxicology Program (NTP). 2007. NTP technical report on the photocarcinogenesis study of glycolic acid and salicylic acid (CASRN 79-14-1 and 69-72-7) in SKH-1 mice (simulated solar light and topical application study). Research Triangle Park, NC: National Toxicology Program. Technical Report 524. https://ntp.niehs.nih.gov/go/tr524abs

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding 1-bromopropane (1-BP) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., Proposition 65). The listing of the chemical is effective December 7, 2004.Toxicological Endpoint: Developmental, female reproductive and male reproductive toxicity

National Toxicology Program (NTP). 2003. NTP-CERHR monograph on the potential human reproductive and developmental effects of 1-bromopropane. Research Triangle Park, NC: Center for the Evaluation of Risks to Human Reproduction, National Toxicology Program. https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/bromopropanes/1-bromopropane/1bp_monograph.pdf

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding riddelliine to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of riddelliine is effective December 3, 2004. Toxicological Endpoint: Cancer

NTP (National Toxicology Program). 2011. Riddelliine. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/riddelliine.pdf

National Toxicology Program (NTP). 2003. NTP technical report on the toxicology and carcinogenesis studies of riddelliine (CASRN 23246-96-0) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 508. https://ntp.niehs.nih.gov/go/tr508abs

The EPA is amending the list of hazardous air pollutants contained in section 112(b)(1) of the Clean Air Act by removing the compound ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol)(CAS No. 111-76-2) from the group of glycolethers.

National Toxicology Program (NTP). 2000a. NTP technical report on the toxicology and carcinogenesis studies of 2-butoxyethanol (CASRN 111-76-2) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 484. https://ntp.niehs.nih.gov/go/tr484abs

The Mine Safety and Health Administration (MSHA) is withdrawing the remaining phases of its 1989 “Air Quality, Chemical Substances, and Respiratory Protection” proposed rule.

NTP. Lead oxide (1317-36-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). DOI: https://doi.org/10.22427/NTP-DATA-DTXSID601014496

The EPA is promulgating national emission standards forhazardous air pollutants for industrial, commercial, and institutional boilers and process heaters and has identified industrial, commercial, and institutional boilers and process heaters as major sources of hazardous air pollutants.

National Toxicology Program (NTP). 1992. NTP technical report on the toxicology and carcinogenesis studies of chlorinated water and chloraminated water (deionized and charcoal-filtered) (CASRNs 7782-50-5, 7681-52-9 and 10599-90-3) in F344/N rats and B6C3F1 mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 392. https://ntp.niehs.nih.gov/go/tr392abs

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding aristolochic acids and herbal remedies containing plant species of the genus Aristolochia to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of \"aristolochic acids and herbal remedies containing plant species of the genus Aristolochia is effective July 9, 2004. Toxicological Endpoint: Cancer

NTP (National Toxicology Program). 2011. Aristolochic acids. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/aristolochicacids.pdf

Amends the Alcohol and Tobacco Tax and Trade Bureau's labeling regulations to remove the requirement for bottlers of wine, distilled spirits, and malt beverages to show a warning on products containing saccharin. The regulatory amendments in this document reflect the National Toxicology Program's revised findings about saccharin and the removal of the statutory requirement for the warning.

NTP (National Toxicology Program). 1980. Report on Carcinogens, first edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

NTP (National Toxicology Program). 2000. Report on Carcinogens, ninth edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding 3,3'-dimethoxybenzidine-(DMOB)based dyes metabolized to 3,3'-dimethoxybenzidine, 3,3'-dimethylbenzidine- (DMB)based dyes metabolized to 3,3'-dimethylbenzidine, ethylbenzene, propylene glycol mono-t-butyl ether, and thiouracil to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., Proposition 65). The listing of these chemicals is effective June 11, 2004. Toxicological Endpoint: Cancer

National Toxicology Program (NTP). 2004. NTP technical report on the toxicology and carcinogenesis studies of propylene glycol mono-t-butyl ether (CASRN 57018-52-7) in F344/N rats and B6C3F1 mice and a toxicology study of propylene glycol mono-t-butyl ether (CASRN 57018-52-7) in male NBR rats (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 515. https://ntp.niehs.nih.gov/go/tr515abs

NTP (National Toxicology Program). 2002. 3,3′-dimethylbenzidine and dyes metabolized to 3,3′-dimethylbenzidine. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dimethylbenzidineanddyes.pdf

NTP (National Toxicology Program). 2002. 3,3′-dimethoxybenzidine and dyes metabolized to 3,3′-dimethoxybenzidine. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dimethoxybenzidineanddyes.pdf

The FDA is requesting the submission of data and information on furan, a heat treatment related byproduct that has been detected in certain thermally treated foods.

National Toxicology Program (NTP). 1993. NTP technical report on the toxicology and carcinogenesis studies of furan (CASRN 110-00-9) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 402. https://ntp.niehs.nih.gov/go/tr402abs

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding nickel compounds to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of nickel compounds is effective May 7, 2004. Toxicological Endpoint: Cancer

NTP (National Toxicology Program). 2002. Nickel compounds and metallic nickel. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nickel.pdf

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the publication of the final Public Health Goal (PHG) for arsenic.

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of roxarsone (CASRN 121-19-7) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 345. https://ntp.niehs.nih.gov/go/tr345abs

Final Rule Declaring Dietary Supplements Containing Ephedrine Alkaloids Adulterated Because They Present an Unreasonable Risk

National Toxicology Program (NTP). 1986. NTP technical report on the toxicology and carcinogenesis studies of ephedrine sulfate (CASRN 134-72-5) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 307. https://ntp.niehs.nih.gov/go/tr307abs

The Toxic Substances Control Act (TSCA) Interagency TestingCommittee (ITC) transmitted its Fifty-Third Report to the Administrator of the EPA on December 2, 2003 revising the Priority Testing List by adding 3 pyridinamines and 20 tungsten compounds requesting that EPA add the 3pyridinamines and 20 tungsten compounds to the TSCA section 8(a) Preliminary Assessment Information Reporting (PAIR) rule and soliciting voluntary use, exposure, and effects information for 3 pyridinamines, 20 tungsten compounds, and 43 vanadium compounds through its Voluntary Information Submissions Innovative Online Network.

National Toxicology Program (NTP). 2009. NTP Report on Carcinogens background document for cobalt–tungsten carbide: powders and hard metals. Research Triangle Park, NC: National Toxicology Program. https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/hardmetalsbd20100408_508.pdf

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding fumonisin B1 to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of fumonisin B1 is effective November 14, 2003 Toxicological Endpoint: Cancer

The Food and Drug Administration (FDA) is announcing final recommendations to revise the permitted daily exposures (PDEs) for two solvents, n-methylpyrrolidone (NMP) and tetrahydrofuran (THF), according to the maintenance procedures for the guidance for industry entitled “Q3C Impurities: Residual Solvents.” The final recommendations were reached under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH).

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the availability of the final technical support documents for a Public Health Goal (PHG) for each of the following eleven (11) chemicals in drinking water.

National Toxicology Program (NTP). 1990c. NTP technical report on the toxicology and carcinogenesis studies of tremolite (CASRN 14567-73-8) in F344/N rats (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 277. https://ntp.niehs.nih.gov/go/tr277abs

NTP (National Toxicology Program). 2000. Asbestos. Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/asbestos.pdf

National Toxicology Program (NTP). 1982. Carcinogenesis bioassay of di(2-ethylhexyl)adipate (CASRN 103-23-1) in F344 rats and B6C3F1 mice (feed study). Research Triangle Park, NC: National Toxicology Program. Technical Report 212. https://ntp.niehs.nih.gov/go/tr212abs

National Toxicology Program (NTP). 1985. NTP Technical report on the toxicology and carcinogenesis studies of chlorobenzene (CASRN 108-90-7) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 261. https://ntp.niehs.nih.gov/go/tr261abs

National Toxicology Program (NTP). 1982. Carcinogenesis bioassay of 1,2-dibromoethane (CASRN 106-93-4) in F344 rats and B6C3F1 mice (inhalation study). Research Triangle Park, NC: National Toxicology Program. Technical Report 210. https://ntp.niehs.nih.gov/go/tr210abs

National Toxicology Program (NTP). 1994. NTP technical report on the toxicology and carcinogenesis studies of barium chloride dihydrate (CASRN 10326-27-9) in F344/N rats and B6C3F1 mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 432. https://ntp.niehs.nih.gov/go/tr432abs

The Food and Drug Administration (FDA) is announcing its intent to withdraw certain advance notice of proposed rulemakings (ANPRMs), proposed rules, and other proposed actions that published in the Federal Register more than 5 years ago. These proposals rules are no longer considered viable candidates for final action at this time. FDA is taking this action to reduce its regulatory backlog and focus its resources on current public health issues.

Docket No. 81N-0281

National Toxicology Program (NTP). National Toxicology Program Archives (AARC). Research Triangle Park, NC: National Toxicology Program. https://nihsci.nlm.nih.gov/collections/10160

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding strong inorganic acid mists containing sulfuric acid to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of strong inorganic acid mists containing sulfuric acid is effective March 14, 2003. Toxicological Endpoint: Cancer

The FDA is prohibiting the extralabel use of phenylbutazone animal and human drugs in female dairy cattle 20 months of age or older. The extralabel use presents a risk to the public health.

The EPA has established an exemption from the tolerance requirements pursuant to FFDCA 408(c) and 9(d) for residues of certain Sucrose Octanoate Esters (SOEs) in or on all food commodities when applied/used in accordance with good agricultural practices.

National Toxicology Program (NTP). Testing status of octanoic acid M20419, CASRN 124-07-2. Research Triangle Park, NC: National Toxicology Program. https://doi.org/10.22427/NTP-DATA-DTXSID3021645

The EPA is soliciting public comment on whether a preliminary determination that nine contaminants do not meet all three Safe Drinking Water Act requirements is appropriate, and thus no National Primary Drinking Water Regulations (NPDWR) should be considered for these contaminants.

National Toxicology Program (NTP). 1991. NTP technical report on the toxicity studies of hexachloro-1,3-butadiene (CASRN 87-68-3) in B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Toxicity Report 1. https://ntp.niehs.nih.gov/go/tox001abs

National Toxicology Program (NTP). 1992. NTP technical report on the toxicology and carcinogenesis studies of naphthalene (CASRN 91-20-3) in B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 410. https://ntp.niehs.nih.gov/go/tr410abs

National Toxicology Program (NTP). 2000. NTP technical report on the toxicology and carcinogenesis studies of naphthalene (CASRN 91-20-3) in F344/N rats (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 500. https://ntp.niehs.nih.gov/go/tr500abs

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding pyridine to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of pyridine is effective May 17, 2002. Toxicological Endpoint: Cancer

National Toxicology Program (NTP). 2000. NTP technical report on the toxicology and carcinogenesis studies of pyridine (CASRN 110-86-1) in F344/N rats, Wistar rats, and B6C3F1 mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 470. https://ntp.niehs.nih.gov/go/tr470abs

EPA announces the initial filing of a pesticide petition proposing the establishment of regulations for residues of a certain pesticide chemical in or on various food commodities.

National Toxicology Program (NTP). 1990. NTP technical report on the toxicology and carcinogenesis studies of sodium fluoride (CASRN 7681-49-4) in F344/N rats and B6C3F1 mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 393. https://ntp.niehs.nih.gov/go/tr393abs

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding naphthalene to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of naphthalene is effective April 19, 2002. Toxicological Endpoint: Cancer

National Toxicology Program (NTP). 2000. NTP technical report on the toxicology and carcinogenesis studies of naphthalene (CASRN 91-20-3) in F344/N rats (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 500. https://ntp.niehs.nih.gov/go/tr500abs

EPA intends to reclassify eight inert ingredients from List 2, Potentially Toxic Inerts/High Priority for Testing to List 1 Inerts of Toxicological Concern. One of the criteria for being considered a List 1 inert ingredient is to be characterized by the NTP as an animal carcinogen in at least one species and sex.

National Toxicology Program (NTP). 1994. NTP technical report on the toxicology and carcinogenesis studies of o-benzyl-p-chlorophenol in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 424. https://ntp.niehs.nih.gov/go/tr424abs

National Toxicology Program (NTP). 2000. NTP technical report on the toxicology and carcinogenesis studies of 2-butoxyethanol (CASRN 111-76-2) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 484. https://ntp.niehs.nih.gov/go/tr484abs

National Toxicology Program (NTP). 1982. NTP technical report on the carcinogenesis bioassay of butyl benzyl phthalate (CASRN 85-68-7) in F344/N rats and B6C3F1 mice (feed study). Research Triangle Park, NC: National Toxicology Program. Technical Report 213. https://ntp.niehs.nih.gov/go/tr213abs

National Toxicology Program (NTP). 1997. NTP technical report on the toxicology and carcinogenesis studies of butyl benzyl phthalate (CASRN 85-68-7) in F344 rats (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 458. https://ntp.niehs.nih.gov/go/tr458abs

National Toxicology Program (NTP). 1999. NTP technical report on the toxicology and carcinogenesis studies of diethanolamine (CASRN 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 478. https://ntp.niehs.nih.gov/go/tr478abs

National Toxicology Program (NTP). 1999. NTP technical report on the toxicology and carcinogenesis studies of ethylbenzene (CASRN 100-41-4) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 466. https://ntp.niehs.nih.gov/go/tr466abs

National Toxicology Program (NTP). 1988. NTP technical report on the toxicology and carcinogenesis studies of 1,2-epoxybutane (CASRN 106-88-7) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 329. https://ntp.niehs.nih.gov/go/tr329abs

National Toxicology Program (NTP). 1988. NTP technical report on the toxicology and carcinogenesis studies of 2-mercaptobenzothiazole (CASRN 149-30-4) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 332. https://ntp.niehs.nih.gov/go/tr332abs

National Toxicology Program (NTP). 1997. NTP technical report on the toxicology and carcinogenesis studies of nitromethane (CASRN 75-52-5) in F344 rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 461. https://ntp.niehs.nih.gov/go/tr461abs

National Toxicology Program (NTP). 1995. NTP technical report on one-year initiation/promotion study of o-benzyl-p-chlorophenol (CASRN 120-32-1) in Swiss (CD-1) Mice (mouse skin study). Research Triangle Park, NC: National Toxicology Program. Technical Report 444. https://ntp.niehs.nih.gov/go/tr444abs

This regulation establishes a tolerance for combined residues of diflubenzuron and its metabolites 4-chloroaniline and 4-chlorophenylurea in or on pear. IR-4 requested this tolerance under the Federal Food, Drug, and Cosmetic Act (FFDCA), as amended by the Food Quality Protection Act (FQPA) of 1996.

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of para-chloroaniline hydrochloride (CASRN 20265-96-7) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 351. https://ntp.niehs.nih.gov/go/tr351abs

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding the chemical methyleugenol to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The chemical is listed effective November 16, 2001. Toxicological Endpoint: Cancer

National Toxicology Program (NTP). 2000. NTP technical report on the toxicology and carcinogenesis studies of methyleugenol (CASRN 93-15-2) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 491. NIH Publication No. 00-3950. https://ntp.niehs.nih.gov/go/tr491abs

Substances added directly to human food affirmed as generally recognized as safe (GRAS).

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of two pentachlorophenol technical-grade mixtures (CASRN 87-86-5) in B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 349. https://ntp.niehs.nih.gov/go/tr349abs

The EPA is proposing AEGLs for 18 chemicals to provide Federal, State, and local agencies with threshold short-term exposure limits for the public to hazardous, airborne chemicals.

National Toxicology Program (NTP). 1986. NTP technical report on the toxicology and carcinogenesis studies of tetrachloroethylene (perchloroethylene) (CASRN 127-18-4) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 311. https://ntp.niehs.nih.gov/go/tr311abs

National Toxicology Program (NTP). 1990. NTP technical report on the toxicology and carcinogenesis studies of tetranitromethane (CASRN 509-14-8) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 386. https://ntp.niehs.nih.gov/go/tr386abs

The California Environmental Protection Agency's Office of Environmental Health Hazard Assessment (OEHHA) is the lead agency for the implementation of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). As the lead agency, OEHHA is removing saccharin from the list of chemicals known to the state to cause cancer, for purposes of Proposition 65.Saccharin [CAS No. 81-07-2] was originally added to the Proposition 65 list on October 1, 1989. This chemical was added to the Proposition 65 list as a result of the issuance of a judicial decision enforcing Labor Code Section 6382(b)(1) and (d) which are incorporated by reference as Proposition 65 listing provisions pursuant to Health and Safety Code Section 25249.8(b). Labor Code Section 6382(b)(1) requires inclusion of substances listed as human or animal carcinogens by the International Agency for Research on Cancer (IARC). Labor Code Section 6382(d) requires the inclusion of chemicals identified as carcinogens or potential carcinogens by IARC or the National Toxicology Program (NTP). Saccharin was identified by IARC and NTP as causing cancer.

National Toxicology Program (NTP). 2000. Report on carcinogens, ninth edition: carcinogen profiles. U.S. Department of Health and Human Services, Public Health Service, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/roc

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding thirteen chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The chemicals are listed effective February 27, 2001.Ethoprop, indium phosphide, lynestrenol, norethynodrel, and propachlor are listed pursuant to an administrative listing mechanism provided under Proposition 65, based upon a formal identification by an authoritative body that the chemicals cause cancer.

National Toxicology Program (NTP). 2000. NTP technical report on the toxicology and carcinogenesis studies of indium phosphide (CASRN 22398-80-7) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 499. https://ntp.niehs.nih.gov/go/tr499abs

The Department of Labor is establishing new health standards for underground coal mines that use equipment powered by diesel engines. High concentrations of diesel particulate matter (DPM) increases the risk of serious health hazards in underground mines.

National Toxicology Program (NTP). 2000. Report on carcinogens, ninth edition: carcinogen profiles. U.S. Department of Health and Human Services, Public Health Service, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/roc

The EPA is setting new diesel exhaust emission standards for heavy-duty highway engines to protect the public's health. Health studies indicate potential hazards that appear to be related to acute and chronic exposure.

National Toxicology Program (NTP). 2000. Diesel exhaust particulates. Report on Carcinogens, Ninth Edition: Carcinogen Profiles. U.S. Department of Health and Human Services, Public Health Service, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dieselexhaustparticulates.pdf

The EPA is lowering the reporting thresholds for lead and lead compounds which are subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act and section 6607 of the Pollution Prevention Act.

National Toxicology Program (NTP). 2000. Report on carcinogens, eighth edition: carcinogen profiles. U.S. Department of Health and Human Services, Public Health Service, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/roc

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding five chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The chemicals are listed effective December 22, 2000. Bromoethane and isoxaflutole are listed pursuant to an administrative listing mechanism provided under Proposition 65, based upon a formal identification by an authoritative body that the chemicals cause cancer.

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of bromoethane (ethyl bromide) (CASRN 74-96-4) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 363. NTIS Publication No. 90-2818. https://ntp.niehs.nih.gov/go/tr363abs

In this Final Rule, EPA is amending both the Asbestos Worker Protection Rule (WPR) and the Asbestos-in-Schools Rule. The WPR amendment protects State and local government employees from the health risks of exposure to asbestos to the same extent as private sector workers by adopting for these employees the Asbestos Standards of the Occupational Safety and Health Administration (OSHA).

Docket No. FRL-3801-3

National Toxicology Program (NTP). 1988. NTP technical report on the toxicology and carcinogenesis studies of crocidolite asbestos (CASRN 12001-28-4) In F344/N rats (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 280. https://ntp.niehs.nih.gov/go/tr280abs

National Toxicology Program (NTP). 1990. NTP technical report on the toxicology and carcinogenesis studies of amosite asbestos (CASRN 12172-73-5) in F344/N rats (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 279. https://ntp.niehs.nih.gov/go/tr279abs

National Toxicology Program (NTP). 1990. NTP technical report on the toxicology and carcinogenesis studies of tremolite (CASRN 14567-73-8) in F344/N rats (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 277. https://ntp.niehs.nih.gov/go/tr277abs

National Toxicology Program (NTP). 1985. NTP technical report on the toxicology and carcinogenesis studies of chrysotile asbestos (CASRN 12001-29-5) in F344/N rats (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 295. https://ntp.niehs.nih.gov/go/tr295abs

The FDA is amending the food additive regulations to provide for the safe use of hydrogenated butadiene/acrylonitrile copolymers intended for contact with food in repeated use applications. Although the additive itself has not been shown to cause cancer, it has been found to contain residual amounts of acrylonitrile and butadiene, carcinogenic impurities resulting from the manufacture of the additive.

National Toxicology Program (NTP). 1993. NTP technical report on the toxicology and carcinogenesis studies of 1,3-butadiene (CASRN 106-99-0) in B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 434. https://ntp.niehs.nih.gov/go/tr434abs

The Food and Drug Administration (FDA) is issuing a final rule to require the filing of a premarket approval application (PMA) or a notice of completion of a product development protocol (PDP) for the implanted mechanical/hydraulic urinary continence device, a generic type of medical device intended for the treatment of urinary incontinence.

Docket No. 94N-0380

National Toxicology Program (NTP). 1983. NTP technical report on the toxicology and carcinogenesis studies of 4,4'-methylenedianiline dihydrochloride (CASRN 13552-44-8) in F344/N rats and B6C3F1 mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 248. https://ntp.niehs.nih.gov/go/tr248abs

The EPA has established tolerances for combined residues of vinclozolin and its metabolites containing the 3,5-dichloroaniline moiety in or on specific raw agricultural commodities.

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of para-chloroaniline hydrochloride (CASRN 20265-96-7) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 351. https://ntp.niehs.nih.gov/go/tr351abs

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding three chemicals to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The chemicals are listed effective June 2, 2000 pursuant to an administrative listing mechanism provided under Proposition 65, based upon a formal identification by an authoritative body that the chemical causes cancer.

National Toxicology Program (NTP). 1996. NTP technical report on the toxicology and carcinogenesis studies of isobutyl nitrite (CASRN 542-56-3) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 448. https://ntp.niehs.nih.gov/go/tr448abs

National Toxicology Program (NTP). 1998. NTP technical report on the toxicology and carcinogenesis studies of chloroprene (CASRN 126-99-8) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 467. https://ntp.niehs.nih.gov/go/tr467abs

The EPA has received a pesticide petition for establishing a tolerance for residues of diflubenzuron in or on the raw agricultural commodity rangeland grass at 6.0 ppm. P-Chloroaniline (PCA) is a metabolite of diflubenzuron.

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of para-chloroaniline hydrochloride (CASRN 20265-96-7) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 351. https://ntp.niehs.nih.gov/go/tr351abs

The FDA is amending the food additive regulations to provide for the safe use of ethylene-norbornene copolymers as articles or components of articles in contact with dry food. Although the additive itself has not been shown to cause cancer, it has been found to contain minute amounts of benzene, a carcinogenic impurity resulting from the manufacture of the additive.

National Toxicology Program (NTP). 1986. NTP technical report on the toxicology and carcinogenesis studies of benzene (CASRN 71-43-2) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 289. https://ntp.niehs.nih.gov/go/tr289abs

The EPA proposed to terminate the Special Review of 1,3-Dichloropropene (1,3-D). The EPA has determined that the benefits associated with the continued use of 1,3-D under the recently revised terms and conditions of 1,3-D's reregistration outweigh the risks.

National Toxicology Program (NTP). 1985. NTP technical report on the toxicology and carcinogenesis studies of telone II (technical-grade 1,3-dichloropropene (CASRN 542-75-6) containing 1.0% epichlorohydrin as a stabilizer) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 269. https://ntp.niehs.nih.gov/go/tr269abs

The FDA is amending the food additive regulations to provide for the safe use of 4,5-dichloro-1,2-dithiol-3-one as a slimicide in the manufacture of food-contact paper and paperboard. Although the additive itself has not been shown to cause cancer, it has been found to contain minute amounts of tetrachloroethylene, a carcinogenic impurity resulting from the manufacture of the additive.

National Toxicology Program (NTP). 1986. NTP technical report on the toxicology and carcinogenesis studies of tetrachloroethylene (perchloroethylene) (CASRN 127-18-4) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 311. https://ntp.niehs.nih.gov/go/tr311abs

The EPA established tolerances for residues of the insecticide diflubenzuron and its metabolites 4-chlorophenylurea and 4-chloroaniline in/on rice grain at 0.02 ppm and rice straw at 0.8 ppm.

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of para-chloroaniline hydrochloride (CASRN 20265-96-7) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 351. https://ntp.niehs.nih.gov/go/tr351abs

The EPA is denying a petition to remove acetonitrile from the list of chemicals subject to the reporting requirements under section 313 of the Emergency Planning and Community Right-to-Know Act of 1986 (EPCRA) and section 6607 of the Pollution Prevention Act of 1990 (PPA).

National Toxicology Program (NTP). 1996. NTP technical report on the toxicology and carcinogenesis studies of acetonitrile (CASRN 75-05-8) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 447. https://ntp.niehs.nih.gov/go/tr447abs

The FDA is issuing a final rule establishing that the over-the-counter stimulant laxative ingredients danthron and phenolphthalein are not generally recognized as safe and effective and are misbranded.

National Toxicology Program (NTP). 1996. NTP technical report on the toxicology and carcinogenesis studies of phenolphthalein (CASRN 77-09-8) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 465. NTIS Publication No. 97-3390. https://ntp.niehs.nih.gov/go/tr465abs

This Notice provides the status of ATSDR's Superfund mandated Substance-Specific Applied Research Program (SSARP). To date, 188 priority data needs have been identified for the 50 priority hazardous substances frequently found at waste sites.

NTP. Carbon tetrachloride (56-23-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). DOI: https://doi.org/10.22427/NTP-DATA-DTXSID8020250

EPA is finalizing maximum residual disinfectant level goals (MRDLGs) for chlorine, chloramines, and chlorine dioxide; maximum contaminant level goals (MCLGs) for four trihalomethanes (chloroform, bromodichloromethane, dibromochloromethane, and bromoform), two haloacetic acids (dichloroacetic acid and trichloroacetic acid), bromate, and chlorite; and National Primary Drinking Water Regulations (NPDWRs) for three disinfectants (chlorine, chloramines, and chlorine dioxide), two groups of organic disinfection byproducts (total trihalomethanes (TTHMs)—a sum of the four listed above, and haloacetic acids (HAA5)—a sum of the two listed above plus monochloroacetic acid and mono and dibromoacetic acids), and two inorganic disinfection byproducts (chlorite and bromate).

National Toxicology Program (NTP). 1987. NTP technical report on the toxicology and carcinogenesis studies of bromodichloromethane (CASRN 75-27-4) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 321. https://ntp.niehs.nih.gov/go/tr321abs 

National Toxicology Program (NTP). 1992. NTP technical report on the toxicology and carcinogenesis studies of chlorinated water (CASRNs 7782-50-5 and 7681-52-9) and chloraminated water (CASRN 10599-90-3) (deionized and charcoal-filtered) in F344/N rats and B6C3F1 mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 392. https://ntp.niehs.nih.gov/go/tr392abs

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of tribromomethane (bromoform) (CASRN 75-25-2) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 350. https://ntp.niehs.nih.gov/go/tr350abs

National Toxicology Program (NTP). 1985. NTP technical report on the toxicology and carcinogenesis studies of chlorodibromomethane (CASRN 124-48-1) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 282. https://ntp.niehs.nih.gov/go/tr282abs

The FDA is amending the food additive regulations to provide for the safe use of 2,9-dichloro-5,12-dihydroquinone[2,3-b]acridine-7,14-dione (C.I. Pigment Red 202) as a colorant for polymers used in contact with food. Although the additive itself has not been shown to cause cancer, it has been found to contain minute amounts of para-chloroaniline, a carcinogenic impurity resulting from the manufacture of the additive.

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of para-chloroaniline hydrochloride (CASRN 20265-96-7) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 351. https://ntp.niehs.nih.gov/go/tr351abs

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has added 28 chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity, for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 or the Act). These chemicals are listed effective May 15, 1998. Toxicological Endpoint: Cancer

National Toxicology Program (NTP). 1997. NTP technical report on the toxicology and carcinogenesis studies of salicylazosulfapyridine (CASRN 599-79-1) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 457. NTIS Publication No. 97-3373. https://ntp.niehs.nih.gov/go/tr457abs

National Toxicology Program (NTP). 1996. NTP technical report on the toxicology and carcinogenesis studies of phenolphthalein (CASRN 77-09-8) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 465. NTIS Publication No. 97-3390. https://ntp.niehs.nih.gov/go/tr465abs

National Toxicology Program (NTP). 1996. NTP technical report on comparative toxicity and carcinogenicity studies of o-nitrotoluene and o-toluidine hydrochloride (CASRNs 88-72-2 and 636-21-5) administered in feed to male F344/N rats. NTP Toxicity Report Series No. 44. NTIS Publication Number 96-3936. https://ntp.niehs.nih.gov/go/tox044abs

National Toxicology Program (NTP). 1994. Seventh annual Report on Carcinogens: volume 1: 357-362. US Department of Health and Human Services, NTP, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/roc

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of nalidixic acid (CASRN 389-08-2) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 368. NTIS Publication No. 90-2823. https://ntp.niehs.nih.gov/go/tr368abs

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of para-chloroaniline hydrochloride (CASRN 20265-96-7) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 351. https://ntp.niehs.nih.gov/go/tr351abs

National Toxicology Program (NTP). 1987. NTP technical report on the toxicology and carcinogenesis studies of methyl carbamate (CASRN 598-55-0) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 328. NTIS Publication No. 88-2584. https://ntp.niehs.nih.gov/go/tr328abs

National Toxicology Program (NTP). 1982. Carcinogenesis bioassay of C.I. solvent yellow 14 (CASRN 842-07-9) in F344/N rats and B6C3F1 mice (feed study). Research Triangle Park, NC: National Toxicology Program. Technical Report 226. NTIS Publication No. 82-1782. https://ntp.niehs.nih.gov/go/tr226abs

National Toxicology Program (NTP). 1981. Carcinogenesis bioassay of cytembena (CASRN 21739-91-3). Research Triangle Park, NC: National Toxicology Program. Technical Report 207. NTIS Publication No. 81-1763. https://ntp.niehs.nih.gov/go/tr207abs

This regulation establishes a temporary tolerance for residues of the insecticide diflubenzuron and metabolites convertible to p-chloroaniline (PCA) expressed as diflubenzuron on rice grain at 0.01 ppm.

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of para-chloroaniline hydrochloride (CASRN 20265-96-7) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 351. https://ntp.niehs.nih.gov/go/tr351abs

EPA is adding tribromophenol and wastes generated from its production to its list of CERCLA hazardous substances. EPA used structure activity relationship (SAR) analysis information in support of its listing of tribromophenol.

National Toxicology Program (NTP). 1982. Carcinogenesis bioassay of 1,2-dibromoethane (CASRN 106-93-4) in F344 rats and B6C3F1 mice (inhalation study). Research Triangle Park, NC: National Toxicology Program. Technical Report 210. NTIS no. PB82- 181710. https://ntp.niehs.nih.gov/go/tr210abs

National Cancer Institute (NCI). 1978. Bioassay of technical grade 1,2-dichloroethane for possible carcinogenicity. Bethesda, MD: Division of Cancer Cause and Prevention, Carcinogenesis Testing Program. NCI-CG-TR55. https://ntp.niehs.nih.gov/go/tr055abs

The Safe Drinking Water Act (SDWA), as amended in 1996, requires the Environmental Protection Agency (EPA) to publish a list of contaminants which, at the time of publication, are not subject to any proposed or promulgated national primary drinking water regulation (NPDWR), that are known or anticipated to occur in public water systems and which may require regulations under the SDWA [section 1412(b)(1)].

National Toxicology Program (NTP). 1996. NTP renal toxicity studies of selected halogenated ethanes administered by gavage to F344/N rats. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 45. https://ntp.niehs.nih.gov/go/tox045abs

National Toxicology Program (NTP). 1992. NTP technical report on the toxicology and carcinogenesis studies of methyl bromide (CASRN 74-83-9) in B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 385.https://ntp.niehs.nih.gov/go/tr385abs

This final standard, which replaces the respiratory protection standards adopted by OSHA in 1971 (29 CFR 1910.134 and 29 CFR 1926.103), applies to general industry, construction, shipyard, longshoring, and marine terminal workplaces. The standard requires employers to establish or maintain a respiratory protection program to protect their respirator wearing employees.

Docket No. H049

National Toxicology Program (NTP). 1982. NTP technical report on the carcinogenesis bioassay of di(2-ethylhexyl)phthalate (CASRN 117-81-7) in F344 rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 217. https://ntp.niehs.nih.gov/go/tr217abs

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has added 18 chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity, for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 or the Act). These chemicals are listed effective August 26, 1997. Toxicological Endpoint: Cancer

National Toxicology Program (NTP). 1992. NTP technical report on the toxicology and carcinogenesis studies of C.I. direct blue 15 (CASRN 2429-74-5) in F344/N rats and B6C3F1 mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 397. https://ntp.niehs.nih.gov/go/tr397abs

National Toxicology Program (NTP). 1994. NTP technical report on the toxicology and carcinogenesis studies of 1-amino-2,4-dibromoanthraquinone (CASRN 81-49-2) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 383. https://ntp.niehs.nih.gov/go/tr383abs

National Toxicology Program (NTP). 1994. NTP technical report on the toxicology and carcinogenesis studies of C.I. direct blue 218 (CASRN 28407-37-6) in F344/N rats and B6C3F1 mice (feed studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 430. https://ntp.niehs.nih.gov/go/tr430abs

OSHA approves, subject to certain conditions, the California Hazard Communication Standard, including Proposition 65 -- the California Safe Drinking Water and Toxic Enforcement Act.

NTP (National Toxicology Program). 1994. Report on Carcinogens, seventh edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc

The EPA is proposing to add a chemical category that includes dioxin and 27 dioxin-like compounds to the list of toxic chemicals subject to the reporting requirements under EPCRA.

National Toxicology Program (NTP). 1980. Bioassay of a mixture of 1,2,3,6,7,8-hexachlorodibenzo-p-dioxin (CASRN 57653-85-7) and 1,2,3,7,8,9-hexachlorodibenzo-p-dioxin (CASRN 19408-74-3) (gavage) for possible carcinogenicity. Research Triangle Park, NC: National Toxicology Program. Technical Report 198. https://ntp.niehs.nih.gov/go/tr198abs

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency has added nine chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity, for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). These chemicals are listed effective May 1, 1997. Toxicological Endpoint: Cancer

National Toxicology Program (NTP). 1995. NTP technical report on the toxicology and carcinogenesis studies of nitromethane (CASRN 75-52-5) in F344 rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 461. https://ntp.niehs.nih.gov/go/tr461abs

National Toxicology Program (NTP). 1995. NTP technical report on the toxicology and carcinogenesis studies of tetrafluoroethylene (CASRN 116-14-3) in F344 rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 450. https://ntp.niehs.nih.gov/go/tr450abs

Notice of informal public hearings concerning OSHA's proposal to modify the existing provisions for controlling employee exposure to methylene chloride.

Docket No. H-71

National Toxicology Program (NTP). NTP technical report on the toxicology and carcinogenesis studies of dichloromethane (methylene chloride) (CASRN 75-09-2) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 306. https://ntp.niehs.nih.gov/go/tr306abs

Final Rule: The FDA is amending the food additive regulations to provide for the safe use of 2,2-ethylidenebis(4,6-di-tert-butylphenyl)fluorophosphonite as an antioxidant in adhesives and in the preparation of polymers intended for contact with food. Although the additive itself has not been shown to cause cancer, it has been found to contain minute amounts of methylene chloride, which is a carcinogenic impurity resulting from the manufacture of the additive.

National Toxicology Program (NTP). 1986. NTP technical report on the toxicology and carcinogenesis studies of dichloromethane (methylene chloride) (CASRN 75-09-2) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 306. https://ntp.niehs.nih.gov/go/tr306abs

EPA is withdrawing a proposed significant new use rule (SNUR) for certain acrylate substances based on receipt of new toxicity data.

National Toxicology Program (NTP). 1986. NTP technical report on the carcinogenesis studies of ethyl acrylate (CASRN 140-88-5) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 259. https://ntp.niehs.nih.gov/go/tr259abs

EPA is denying a petition to remove the barium compounds category from the list of chemicals subject to reporting requirements under the Community Right-to-Know Act and the Pollution Prevention Act. The EPA concluded that barium ion can become available from the barium compounds subject to the reporting, and that barium ion can reasonably be anticipated to cause chronic toxicity.

National Toxicology Program (NTP). 1994. NTP technical report on the toxicology and carcinogenesis studies of barium chloride dihydrate (CASRN 10326-27-9) in F344/N rats and B6C3F1 mice (drinking water studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 432. https://ntp.niehs.nih.gov/go/tr432abs

Notice: The EPA has made available the final Guidelines for Reproductive Toxicity Risk Assessment. The Guidelines include protocols designed to determine the potential of a test substance to produce reproductive toxicity in laboratory animals.

National Toxicology Program (NTP). 1985. Fertility (or reproductive) assessment by continuous breeding protocol. National Institute of Environmental Health Sciences, Research Triangle Park, NC. https://ntp.niehs.nih.gov/go/128

The EPA is promulgating a new use rule which requires persons to notify the EPA at least 90 days before commencing the manufacture, import, or processing of certain (22) benzidine-based chemical substances for significant new use as described in this rule.

National Toxicology Program (NTP). 1978. 13-week subchronic toxicity studies of direct blue 6 (CASRN 2602-46-2), direct black 38 (CASRN 1937-37-7), and direct brown 95 (CASRN 16071-86-6) dyes. Research Triangle Park, NC: National Toxicology Program. Technical Report 108. https://ntp.niehs.nih.gov/go/tr108abs

The Food and Drug Administration (FDA) is amending the food additive regulations to provide for the safe use of a copolymer of ethyl acrylate, methyl methacrylate, and methacrylamide in combination with melamine-formaldehyde resin as a coating for polyethylene phthalate films intended for use in contact with food. Although the additive itself has not been shown to cause cancer, it has been found to contain minute amounts of unreacted ethyl acrylate, which is a carcinogenic impurity resulting from the manufacture of the additive.

National Toxicology Program (NTP). 1986. NTP technical report on the toxicology and carcinogenesis studies of ethyl acrylate (CASRN 140-88-5) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 259. https://ntp.niehs.nih.gov/go/tr259abs

The Food and Drug Administration (FDA) is amending the food additive regulations to provide for the safe use of 1,2-benzisothiazolin-3-one as a biocide in rubber latex for use in the manufacture of rubber articles intended for repeated use in contact with food. In its evaluation of the safety of this additive, the FDA has reviewed the safety of the additive itself and that of polychlorinated dibenzo-p-dioxins (PCDD) and dibenzo-p-dioxins impurities resulting from the manufacturing process.

National Toxicology Program (NTP). 1986. Classification of liver tumors. National Institute of Environmental Health Sciences, Research Triangle Park, NC. https://ntp.niehs.nih.gov/atlas/nnl

The Food and Drug Administration (FDA) is amending the food additive regulations to provide for the safe use of phosphorylated tall oil fatty acids as pigment dispersants in polymeric films intended for use in contact with food. Although the additive itself has not been shown to cause cancer, it has been found to contain minute amounts of dimethyl hydrogen phosphite, which is a carcinogenic impurity resulting from the manufacture of the additive.

National Toxicology Program (NTP). 1985. NTP technical report on the toxicology and carcinogenesis studies of dimethyl hydrogen phosphite (CASRN 868-85-9) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 287. https://ntp.niehs.nih.gov/go/tr287abs

The Food and Drug Administration (FDA) is amending the food additive regulations to provide for the safe use of polyaryletherketone resins as a basic resin for use in food-contact materials. Although the additive itself has not been shown to cause cancer, it has been found to contain minute amounts of methylene chloride, which is a carcinogenic impurity resulting from the manufacture of the additive.

National Toxicology Program (NTP). 1986. NTP technical report on the toxicology and carcinogenesis studies of dichloromethane (methylene chloride) (CASRN 75-09-2) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 306. https://ntp.niehs.nih.gov/go/tr306abs

EPA is deleting di-(2-ethylhexyl) adipate (DEHA) (CAS No. 103-23-1), also known as bis(2-ethylhexyl) adipate, from the list of chemicals subject to reporting requirements under section 313 of the Emergency Planning and Community Right-to-Know Act of 1986 (EPCRA) and section 6607 of the Pollution Prevention Act of 1990 (PPA).

National Toxicology Program (NTP). 1982. Carcinogenesis bioassay of di(2-ethylhexyl)adipate (CASRN 103-23-1) in F344 rats and B6C3F1 mice (feed study). Research Triangle Park, NC: National Toxicology Program. Technical Report 212. https://ntp.niehs.nih.gov/go/tr212abs

EPA is deleting diethyl phthalate (DEP) from the list of chemicals subject to the reporting requirements under section 313 of the Emergency Planning and Community.

National Toxicology Program (NTP). 1995. NTP technical report on the toxicology and carcinogenesis studies of diethylphthalate (CASRN 84-66-2) in F344/N rats and B6C3F1 mice (dermal studies) with dermal initiation/promotion study of diethylphthalate (CASRN 84-66-2) and dimethylphthalate (CASRN 131-11-3) in male Swiss (CD-1) mice. Research Triangle Park, NC: National Toxicology Program. Technical Report 429. https://ntp.niehs.nih.gov/go/tr429abs

EPA is revoking six food additive regulations (tolerances) for four pesticides. EPA is revoking four tolerances because they violate the Delaney clause of the Federal Food, Drug, and Cosmetic Act, and the other two tolerances because they are not needed to prevent adulterated food.

NTP. Acephate (30560-19-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). https://cebs.niehs.nih.gov/cebs/test_article/30560-19-1

NTP. Triadimefon (43121-43-3). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).  https://cebs.niehs.nih.gov/cebs/test_article/43121-43-3

NTP. Iprodione (36734-19-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).  https://cebs.niehs.nih.gov/cebs/test_article/36734-19-7

NTP. Imazalil (35554-44-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).  https://cebs.niehs.nih.gov/cebs/test_article/35554-44-0

The EPA announced the publication of the new \"Proposed Guidelines for Carcinogen Risk Assessment\" which replaces the 1986 guidelines.

National Toxicology Program (NTP). 1984. Report of the ad hoc panel on chemical carcinogenesis testing and evaluation of the National Toxicology Program, Board of Scientific Counselors. Washington, DC: U.S. Government Printing Office. 1984–421–132: 4726. https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1984/august/bsc_minutes19840816_508.pdf

EPA has made a final determination regarding 26 food additive regulations (FARs) for 7 pesticides that were previously proposed for revocation on the grounds that the FARs violated the Delaney clause in section 409 of the Federal Food, Drug and Cosmetic Act (FFDCA). Today, EPA is revoking 13 FARs because they violate the Delaney clause and the remaining 13 FARs because they are not needed to prevent adulterated food.

Docket No. RIN 2070-AC18

National Toxicology Program (NTP). 1987. NTP technical report on the toxicology and carcinogenesis studies of ethylene oxide (CASRN 75-21-8) in B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 326. https://ntp.niehs.nih.gov/go/tr326abs

The FDA is amending the food additive regulations to provide for the safe use of sucrose esterified with medium and long chain fatty acids (olestra) as a replacement for fats and oils.

National Toxicology Program (NTP). 1986. Pathology database. National Institute of Environmental Health Sciences, Research Triangle Park, NC.  https://ntp.niehs.nih.gov/atlas/nnl

EPA's issued this Notice to inform the public that the Agency has, after reviewing additional study date, reassessed the potential adverse effects and the benefits associated with the use of pesticide products containing dichlorvos. The Agency has preliminarily determined that, unless the terms and conditions of registration are modified as proposed in this Notice, the risks from the use of dichlorvos outweigh the benefits of their continued use.

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of dichlorvos (CASRN 62-73-7) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 342. https://ntp.niehs.nih.gov/go/tr342abs

The ITC is revising its Priority Testing List including the removal of butyraldehyde; sulfonyl bis(4-chlorobenzene); 2-propenoic acid,2-cyanoethyl ester; and dipropylene glycol from the List as a result of NTP testing.

National Toxicology Program (NTP). Testing Status of butyraldehyde 10247-E (CASRN 123-72-8). Research Triangle Park, NC: National Toxicology Program. https://doi.org/10.22427/NTP-DATA-DTXSID8021513

National Toxicology Program (NTP). Testing Status of dipropylene glycol M88175 (CASRN 25265-71-8). Research Triangle Park, NC: National Toxicology Program. https://doi.org/10.22427/NTP-DATA-DTXSID0027856

National Toxicology Program (NTP). Testing Status of p,p'-dichlorodiphenyl sulfone M882470 (CASRN 80-07-9). Research Triangle Park, NC: National Toxicology Program. https://doi.org/10.22427/NTP-DATA-DTXSID9024986

National Toxicology Program (NTP). Testing Status of ethyl cyanoacrylate M920023 (CASRN 7085-85-0). Research Triangle Park, NC: National Toxicology Program. https://doi.org/10.22427/NTP-DATA-DTXSID1025279

This document establishes an import tolerance for total residues of the insecticide dimethoate including its oxygen analog in or on the raw agricultural commodity blueberries.

NTP. Dimethoate (60-51-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7020479

The EPA has taken final action on reportable quantities (RQs) for hazardous substances under the Comprehensive Environmental Response, Compensation, and Liability Act. The person in charge of a facility or vessel from which a hazardous substance is released in excess of its RQs must notify appropriate authorities, who can then evaluate whether a response is needed.

National Toxicology Program (NTP). 1992. NTP technical report on the toxicity studies of diethanolamine (CASRN 111-42-2) administered topically and in drinking water to F344/N rats and B6C3F1 mice. Research Triangle Park, NC: National Toxicology Program. Toxicity Report 20. https://ntp.niehs.nih.gov/go/tox020abs

The EPA established tolerances for residues of the insecticide diflubenzuron in or on raw agricultural commodities. Para-chloroaniline (PCA) is a metabolite of diflubenzuron.

National Toxicology Program (NTP). 1989. NTP technical report on the toxicology and carcinogenesis studies of para-Chloroaniline hydrochloride (CASRN 20265-96-7) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC: National Toxicology Program. Technical Report 351. https://ntp.niehs.nih.gov/go/tr351abs

EPA is denying a petition to delist monosodium methanearsonate and disodium methanearsonate from the reporting requirements under section 313 of the Emergency Planning and Community Right-to-Know Act of 1986.

NTP (National Toxicology Program). 1984. Report on Carcinogens, seventh edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc