Respiratory System

Nose, Epithelium - Accumulation, Hyaline Droplet

    Narrative
    Nose, Respiratory epithelium - Accumulation, Hyaline droplet in a female B6C3F1/N mouse from a chronic study. The respiratory epithelium and cells of the mucosal gland contain eosinophilic globular material.
    Nose, Respiratory epithelium - Accumulation, Hyaline droplet in a female B6C3F1/N mouse from a chronic study. The respiratory epithelium and cells of the mucosal gland contain eosinophilic globular material.
    Nose, Olfactory epithelium - Accumulation, Hyaline droplet in a female B6C3F1/N mouse from a chronic study. The turbinate epithelial cells contain homogeneous hyaline material. Image provided courtesy of Dr. R. Miller.
    Nose, Olfactory epithelium - Accumulation, Hyaline droplet in a female B6C3F1/N mouse from a chronic study. The turbinate epithelial cells contain homogeneous hyaline material. Image provided courtesy of Dr. R. Miller.
    Nose, Respiratory epithelium - Accumulation, Hyaline droplet in a female B6C3F1/N mouse from a subchronic study (left) and normal nasal respiratory epithelium from a control animal (right). Minimal accumulation of hyaline droplet material is present respiratory epithelium at the respiratory and olfactory epithelial junction of the septum in the treated animal (left), but not in the control mouse (right). Image provided courtesy of Dr. R. Miller.
    Nose, Respiratory epithelium - Accumulation, Hyaline droplet in a female B6C3F1/N mouse from a subchronic study (left) and normal nasal respiratory epithelium from a control animal (right). Minimal accumulation of hyaline droplet material is present respiratory epithelium at the respiratory and olfactory epithelial junction of the septum in the treated animal (left), but not in the control mouse (right). Image provided courtesy of Dr. R. Miller.
    Nose, Respiratory epithelium - Accumulation, Hyaline droplet in a treated female B6C3F1/N mouse (right) and a normal control female B6C3F1/N mouse from a subchronic study (left). Hyaline droplet material is present in the respiratory epithelial cells lining the nasopharyngeal duct from the treated mouse (right) but not in the control mouse (left). Image provided courtesy of Dr. R. Miller.
    Nose, Respiratory epithelium - Accumulation, Hyaline droplet in a treated female B6C3F1/N mouse (right) and a normal control female B6C3F1/N mouse from a subchronic study (left). Hyaline droplet material is present in the respiratory epithelial cells lining the nasopharyngeal duct from the treated mouse (right) but not in the control mouse (left). Image provided courtesy of Dr. R. Miller.

    Authors

    Rodney A. Miller, DVM, PhD, DACVP
    NC Pathology Group Manager
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Ronald Herbert, DVM, PhD
    NTP Pathologist
    Group Leader, Pathology Support Group
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC