Musculoskeletal System

Bone - Necrosis

    Narrative
    Bone, Femur - Necrosis in a male B6C3F1/N mouse from a chronic study. This section of a femur demonstrates focal necrosis (arrowhead) associated with marked joint degeneration.
    Bone, Femur - Necrosis in a male B6C3F1/N mouse from a chronic study. This section of a femur demonstrates focal necrosis (arrowhead) associated with marked joint degeneration.
    Bone, Femur - Necrosis in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). This section of femur illustrates focal necrosis associated with marked joint degeneration.
    Bone, Femur - Necrosis in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). This section of femur illustrates focal necrosis associated with marked joint degeneration.
    Bone, Femur - Necrosis in a male F344/N rat from a chronic study. Focal necrosis is associated with marked joint degeneration in a section of femur.
    Bone, Femur - Necrosis in a male F344/N rat from a chronic study. Focal necrosis is associated with marked joint degeneration in a section of femur.
    Bone, Femur - Necrosis in a male B6C3F1/N mouse from a chronic study. In this section of femur, focal necrosis is associated with marked joint degeneration.
    Bone, Femur - Necrosis in a male B6C3F1/N mouse from a chronic study. In this section of femur, focal necrosis is associated with marked joint degeneration.
    Bone, Vertebra - Necrosis in a male F344/N rat from a chronic study. This section of a vertebra demonstrates marked necrosis characterized by loss of bony architecture, fragmentation, and debris associated with significant fibroplasia and bony remodeling.
    Bone, Vertebra - Necrosis in a male F344/N rat from a chronic study. This section of a vertebra demonstrates marked necrosis characterized by loss of bony architecture, fragmentation, and debris associated with significant fibroplasia and bony remodeling.

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    In Vivo Animal Core,Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Philip H. Long, DVM, PhD, DACVP
    Presiden and Senior Pathologist
    Vet Path Services, Inc.
    Mason, OH

    Joel R. Leininger, DVM, PhD, DACVP
    JRL Consulting, LLC
    Chapel Hill, NC