Reproductive System, Male

Epididymis, Epithelium - Karyomegaly

    Narrative
    Epididymis, Epithelium - Karyomegaly. Atypical enlarged nuclei (arrows) in the epididymal epithelium in a male B6C3F1 mouse from a chronic study.
    Epididymis, Epithelium - Karyomegaly. Atypical enlarged nuclei (arrows) in the epididymal epithelium in a male B6C3F1 mouse from a chronic study.
    Epididymis, Epithelium - Karyomegaly. Multiple enlarge nuclei (arrows) in the epididymis in a B6C3F1 mouse from a chronic study.
    Epididymis, Epithelium - Karyomegaly. Multiple enlarge nuclei (arrows) in the epididymis in a B6C3F1 mouse from a chronic study.
    Epididymis, Epithelium - Karyomegaly. A karyomegalic nucleus (arrow) is projecting into the duct lumen in a B6C3F1 mouse from a chronic study.
    Epididymis, Epithelium - Karyomegaly. A karyomegalic nucleus (arrow) is projecting into the duct lumen in a B6C3F1 mouse from a chronic study.

    Authors:

    Dianne M. Creasy, PhD, Dip RCPath, FRCPath
    Dianne Creasy Consulting LLC
    Pipersville, PA

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Dipak K. Giri, DVM, PhD, DACVP
    Toxicologic Pathologist
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Reviewers:

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    David E. Malarkey DVM, PhD, DACVP, FIATP
    Head, National Toxicology Program Pathology Group
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC