Urinary System
Urinary Bladder - Mineralization
Narrative
Comment:
Mineralization occurs as densely basophilic, granular material (Figure 1 and Figure 2). It usually involves the muscle wall of the urinary bladder. Dystrophic mineralization may be seen secondary to a variety of causes, especially in areas of necrosis. Metastatic mineralization is uncommon in the rodent bladder.
Recommendations:
Mineralization should be diagnosed and given a severity grade when seen in the absence of other lesions (e.g., metastatic mineralization) or, if it is secondary to another process (e.g., dystrophic mineralization), when it is a significant component of the lesion.
References:
Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, Bube A. 2012. Proliferative and non-proliferative lesions in the rat and mouse urinary system. Toxicol Pathol 40:14S-86S.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22637735
Focal basophilic deposits of serosal mineralization from a male F344/N rat in a chronic study.
All Images
Focal basophilic deposits of serosal mineralization from a male F344/N rat in a chronic study.
Focal mineralization (arrow) of the bladder wall from a female B6C3F1 mouse in a subchronic study.