Immune System

Spleen - Fibrosis

    Narrative
    Spleen, Parenchyma - Fibrosis in a male F344/N rat from a chronic study. The splenic red pulp is contracted by fibrous connective tissue (arrow).
    Spleen, Parenchyma - Fibrosis in a male F344/N rat from a chronic study. The splenic red pulp is contracted by fibrous connective tissue (arrow).
    Spleen, Parenchyma - Fibrosis in a male F344/N rat from a chronic study (higher magnification of Figure 1). The splenic white pulp is atrophied (arrow), and there is pigment within the surrounding fibrous connective tissue.
    Spleen, Parenchyma - Fibrosis in a male F344/N rat from a chronic study (higher magnification of Figure 1). The splenic white pulp is atrophied (arrow), and there is pigment within the surrounding fibrous connective tissue.
    Spleen, Capsule - Fibrosis in a male F344/N rat from a chronic study. The splenic capsule is expanded by fibrous connective tissue (arrow).
    Spleen, Capsule - Fibrosis in a male F344/N rat from a chronic study. The splenic capsule is expanded by fibrous connective tissue (arrow).
    Spleen, Capsule - Fibrosis in a male F344/N rat from a chronic study (higher magnification of Figure 3). The fibrotic splenic capsule is lined by hypertrophied mesothelial cells (arrow).
    Spleen, Capsule - Fibrosis in a male F344/N rat from a chronic study (higher magnification of Figure 3). The fibrotic splenic capsule is lined by hypertrophied mesothelial cells (arrow).

    Authors

    Kristen Hobbie, DVM, PhD
    Principal Pathologist
    Huntingdon Life Sciences
    Peterborough, UK

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Holly M. Kolenda-Roberts, DVM, PhD, DACVP
    Veterinary Pathologist
    SNBL USA
    Everett, WA

    Reviewers

    Jerrold M. Ward, DVM, PhD, DACVP, FIATP
    Veterinary Pathologist
    Global VetPathology
    Montgomery Village, MD

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC