Musculoskeletal System

Bone - Callus

    Narrative
    Bone - Callus in a male Wistar rat from a chronic study. There is callus formation surrounding a rib, characterized by a marked proliferative fibrous connective tissue response and bony remodeling.
    Bone - Callus in a male Wistar rat from a chronic study. There is callus formation surrounding a rib, characterized by a marked proliferative fibrous connective tissue response and bony remodeling.
    Bone - callus in a male Wistar rat from a chronic study (higher magnification of figure 1). Section of a bone callus, characterized by a marked proliferative fibrous connective tissue response and bony remodeling.
    Bone - callus in a male Wistar rat from a chronic study (higher magnification of figure 1). Section of a bone callus, characterized by a marked proliferative fibrous connective tissue response and bony remodeling.
    Bone - callus in a male F344/N rat from a chronic study. This section of long bone with a callus is characterized by a focal fibroblastic response (arrowhead).
    Bone - callus in a male F344/N rat from a chronic study. This section of long bone with a callus is characterized by a focal fibroblastic response (arrowhead).
    Bone - callus in a male F344/N rat from a chronic study (higher magnification of figure 3). This bone callus has a focal fibroblastic response and associated osteoid deposition and mineralization (arrowheads).
    Bone - callus in a male F344/N rat from a chronic study (higher magnification of figure 3). This bone callus has a focal fibroblastic response and associated osteoid deposition and mineralization (arrowheads).

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    In Vivo Animal Core,Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Philip H. Long, DVM, PhD, DACVP
    Presiden and Senior Pathologist
    Vet Path Services, Inc.
    Mason, OH

    Joel R. Leininger, DVM, PhD, DACVP
    JRL Consulting, LLC
    Chapel Hill, NC