Clitoral gland duct dilation (Figure 1, Figure 2, Figure 3, Figure 4, Figure 5, Figure 6, Figure 7, Figure 8, Figure 9, Figure 10 and Figure 11) is a common incidental finding in aging rodents. It has also been induced with administration of androgenic steroids. Dilation of the ducts of the clitoral glands is frequently accompanied by atrophy of the glandular tissue. The epithelial lining of smaller ducts may be cuboidal, flattened, or keratinized squamous epithelium. When this condition is severe, the dilated ducts may occupy the majority of the clitoral gland, with remnants of the acinar tissue evident between the dilated ducts, and the glands may be grossly enlarged due to duct dilation. Care must be taken in diagnosing this lesion in mice because mice typically have very cavernous ducts with little glandular tissue.
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