Alimentary System

Tongue - Necrosis

    Narrative
    Tongue - Necrosis in a male Swiss CD-1 mouse from a chronic study. There is widespread necrosis of the tip of the tongue.
    Tongue - Necrosis in a male Swiss CD-1 mouse from a chronic study. There is widespread necrosis of the tip of the tongue.
    Tongue - Necrosis in a male Swiss CD-1 mouse from a chronic study (higher magnification of Figure 1). The necrosis involves all elements of the tongue, including the muscle (arrow) and the epithelium (arrowhead).
    Tongue - Necrosis in a male Swiss CD-1 mouse from a chronic study (higher magnification of Figure 1). The necrosis involves all elements of the tongue, including the muscle (arrow) and the epithelium (arrowhead).
    Tongue - Necrosis in a male Swiss CD-1 mouse from a chronic study (higher magnification of Figure 1). Necrosis of the cornified epithelium (arrow) and abundant inflammation are present.
    Tongue - Necrosis in a male Swiss CD-1 mouse from a chronic study (higher magnification of Figure 1). Necrosis of the cornified epithelium (arrow) and abundant inflammation are present.
    Tongue - Necrosis in a male Swiss CD-1 mouse from a chronic study (higher magnification of Figure 1). Necrosis of the skeletal muscle (arrow) and abundant inflammation are present.
    Tongue - Necrosis in a male Swiss CD-1 mouse from a chronic study (higher magnification of Figure 1). Necrosis of the skeletal muscle (arrow) and abundant inflammation are present.
    Tongue - Necrosis in a male F344/N rat from a chronic study. There is necrosis of the skeletal muscle (arrow).
    Tongue - Necrosis in a male F344/N rat from a chronic study. There is necrosis of the skeletal muscle (arrow).
    Tongue - Necrosis in a male F344/N rat from a chronic study (higher magnification of Figure 5). There is necrosis of the skeletal muscle (arrow).
    Tongue - Necrosis in a male F344/N rat from a chronic study (higher magnification of Figure 5). There is necrosis of the skeletal muscle (arrow).

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC