Hepatobiliary System

Liver, Hepatocyte - Apoptosis

    Narrative
    Liver, Hepatocyte - Apoptosis in a male B6C3F1/N mouse from a subchronic study. There are slightly shrunken, irregularly shaped cells consistent with early-stage apoptosis (arrowheads) and smaller, rounded cells consistent with late-stage apoptosis (arrows); both have hypereosinophilic cytoplasm and small, fragmented nuclei.
    Liver, Hepatocyte - Apoptosis in a male B6C3F1/N mouse from a subchronic study. There are slightly shrunken, irregularly shaped cells consistent with early-stage apoptosis (arrowheads) and smaller, rounded cells consistent with late-stage apoptosis (arrows); both have hypereosinophilic cytoplasm and small, fragmented nuclei.
    Liver, Hepatocyte - Apoptosis in a male B6C3F1/N mouse from a subchronic study. There are small rounded cells consistent with late-stage apoptosis (arrows), and larger, irregular apoptotic cells consistent with early-stage apoptosis (arrowheads).
    Liver, Hepatocyte - Apoptosis in a male B6C3F1/N mouse from a subchronic study. There are small rounded cells consistent with late-stage apoptosis (arrows), and larger, irregular apoptotic cells consistent with early-stage apoptosis (arrowheads).

    Author

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    John Cullen, VMD, PhD, DACVP, FIATP
    Anatomic Pathology, Professor
    North Carolina State University College of Veterinary Medicine
    Raleigh, NC

    David E. Malarkey DVM, PhD, DACVP, FIATP
    Head, National Toxicology Program Pathology Group
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC