Cardiovascular System

Heart - Hemorrhage

    Narrative
    Heart - Hemorrhage in a male F344/N rat from an acute study. Extravasated erythrocytes are present in the myocardium (arrows).
    Heart - Hemorrhage in a male F344/N rat from an acute study. Extravasated erythrocytes are present in the myocardium (arrows).
    Heart - Hemorrhage in a male F344/N rat from an acute study (higher magnification of Figure 1). Extravasated erythrocytes separate cardiomyocytes (arrows).
    Heart - Hemorrhage in a male F344/N rat from an acute study (higher magnification of Figure 1). Extravasated erythrocytes separate cardiomyocytes (arrows).
    Heart - Hemorrhage in a male B6C3F1/N mouse from a subchronic study. Large areas of extravascular red blood cells are present in the myocardium (arrows).
    Heart - Hemorrhage in a male B6C3F1/N mouse from a subchronic study. Large areas of extravascular red blood cells are present in the myocardium (arrows).
    Heart - Hemorrhage in a male B6C3F1/N mouse from a subchronic study (higher magnification of Figure 3). Large areas of extravascular erythrocytes separate cardiomyocytes (arrows).
    Heart - Hemorrhage in a male B6C3F1/N mouse from a subchronic study (higher magnification of Figure 3). Large areas of extravascular erythrocytes separate cardiomyocytes (arrows).

    Authors:

    Crystal L. Johnson, DVM, DACVP
    Veterinary Pathologist II
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Brian Berridge, DVM, PhD, DACVP
    Director, WW Animal Research Strategy
    GlaxoSmithKline R&D
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC