Immune System

Spleen - Necrosis

    Narrative
    Spleen - Necrosis in a male F344/N rat from a chronic study. A large necrotic focus (arrow) is present with the spleen.
    Spleen - Necrosis in a male F344/N rat from a chronic study. A large necrotic focus (arrow) is present with the spleen.
    Spleen - Necrosis in a male F344/N rat from a chronic study (higher magnification of Figure 1). Necrosis is bordered by foci of hemorrhage (arrowhead) and fibrous connective tissue (arrow).
    Spleen - Necrosis in a male F344/N rat from a chronic study (higher magnification of Figure 1). Necrosis is bordered by foci of hemorrhage (arrowhead) and fibrous connective tissue (arrow).
    Spleen - Necrosis in a male B6C3F1/N mouse from a chronic study. A large necrotic focus (arrow) is present with the spleen.
    Spleen - Necrosis in a male B6C3F1/N mouse from a chronic study. A large necrotic focus (arrow) is present with the spleen.
    Spleen - Necrosis in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 3). The necrotic focus is bordered by a mixed inflammatory infiltrate (arrow), fibrosis (arrowhead), and dilated blood vessels.
    Spleen - Necrosis in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 3). The necrotic focus is bordered by a mixed inflammatory infiltrate (arrow), fibrosis (arrowhead), and dilated blood vessels.
    Spleen - Necrosis in a male F344/N rat from a chronic study. A large necrotic focus is present within the splenic red pulp, with focal areas of associated hemorrhage (arrowhead) and bordered by an inflammatory infiltrate (arrow).
    Spleen - Necrosis in a male F344/N rat from a chronic study. A large necrotic focus is present within the splenic red pulp, with focal areas of associated hemorrhage (arrowhead) and bordered by an inflammatory infiltrate (arrow).
    Spleen - Necrosis in a male F344/N rat from a chronic study (higher magnification of Figure 5). The necrotic focus consists of necrotic cellular debris, degenerate neutrophils, and hemorrhage (arrowhead) and is bordered by a rim of histiocytes, lymphocytes, and fibroblasts (arrow).
    Spleen - Necrosis in a male F344/N rat from a chronic study (higher magnification of Figure 5). The necrotic focus consists of necrotic cellular debris, degenerate neutrophils, and hemorrhage (arrowhead) and is bordered by a rim of histiocytes, lymphocytes, and fibroblasts (arrow).

    Authors

    Kristen Hobbie, DVM, PhD
    Principal Pathologist
    Huntingdon Life Sciences
    Peterborough, UK

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Holly M. Kolenda-Roberts, DVM, PhD, DACVP
    Veterinary Pathologist
    SNBL USA
    Everett, WA

    Reviewers

    Jerrold M. Ward, DVM, PhD, DACVP, FIATP
    Veterinary Pathologist
    Global VetPathology
    Montgomery Village, MD

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC