Respiratory System

Lung - Atypia, Cellular

    Narrative
    Lung, Bronchiole - Hyperplasia, Atypical in a female B6C3F1/N mouse from a subchronic study. The atypical cells have enlarged, hyperchromatic nuclei (arrows) and an increased nuclear to cytoplasmic ratio.
    Lung, Bronchiole - Hyperplasia, Atypical in a female B6C3F1/N mouse from a subchronic study. The atypical cells have enlarged, hyperchromatic nuclei (arrows) and an increased nuclear to cytoplasmic ratio.
    Lung, Alveolar epithelium - Atypia, Cellular in a male B6C3F1/N mouse from a subchronic study. Atypical cells (arrows) have enlarged nuclei and may be binucleated.
    Lung, Alveolar epithelium - Atypia, Cellular in a male B6C3F1/N mouse from a subchronic study. Atypical cells (arrows) have enlarged nuclei and may be binucleated.
    Lung, Alveolar epithelium - Atypia, Cellular in a male B6C3F1/N mouse from a chronic study. Several cells have enlarged nuclei (arrows).
    Lung, Alveolar epithelium - Atypia, Cellular in a male B6C3F1/N mouse from a chronic study. Several cells have enlarged nuclei (arrows).
    Lung, Alveolar epithelium - Atypia, Cellular in a male B6C3F1/N mouse from a chronic study. Some type II pneumocytes have enlarged nuclei (arrow).
    Lung, Alveolar epithelium - Atypia, Cellular in a male B6C3F1/N mouse from a chronic study. Some type II pneumocytes have enlarged nuclei (arrow).

    Authors

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist/NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Darlene Dixon, DVM, PhD, DACVP
    Group Leader
    Molecular Pathogenesis Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Ronald A. Herbert, DVM, PhD
    Group Leader/NTP Pathologist
    Pathology Support Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Lauren M. Staska, DVM, PhD, DACVP
    Senior Pathologist
    WIL Research
    Hillsborough, NC

    Reviewers

    Gary A. Boorman, DVM, PhD, DACVP, DABT, DACLAM
    Pathologist
    Covance Laboratories, Inc.
    Chantilly, VA

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC