Immune System

Spleen - Amyloid

    Narrative
    Spleen - Amyloid in a male B6C3F1/N mouse from a chronic study. Amyloid protein (arrow) surrounds and infiltrates the white pulp, which is atrophied (arrowhead).
    Spleen - Amyloid in a male B6C3F1/N mouse from a chronic study. Amyloid protein (arrow) surrounds and infiltrates the white pulp, which is atrophied (arrowhead).
    Spleen - Amyloid in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). Amyloid protein is present within the marginal zone and red pulp (arrows).
    Spleen - Amyloid in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). Amyloid protein is present within the marginal zone and red pulp (arrows).

    Authors

    Kristen Hobbie, DVM, PhD
    Principal Pathologist
    Huntingdon Life Sciences
    Peterborough, UK

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Holly M. Kolenda-Roberts, DVM, PhD, DACVP
    Veterinary Pathologist
    SNBL USA
    Everett, WA

    Reviewers

    Jerrold M. Ward, DVM, PhD, DACVP, FIATP
    Veterinary Pathologist
    Global VetPathology
    Montgomery Village, MD

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC