Endocrine System

Pancreatic Islets - Cyst

Narrative

Comment:

A cyst present in only one islet in a section of pancreas is distinguished from angiectasis based on its large size, lack of an endothelial lining, and the absence of dilation of other vascular spaces (Figure 1 and Figure 2).

Recommendations:

Islet cysts are uncommon but should be documented when present. A severity grade is not required.

References:

References not listed.

All Images

Pancreatic islet - cyst. The central portion of this islet is markedly dilated and is considered a cyst that contains some erythrocytes in a male B6C3F1 mouse from a chronic study.

Pancreatic islet - cyst. High magnification of the cystic islet in Figure 1 in a male B6C3F1 mouse from a chronic study.

Pancreatic islet - cyst. A cyst with an irregular contour is present in this islet in a male B6C3F1 mouse from a chronic study.

Authors and Reviewers

Authors

Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Georgette D. Hill, D.V.M., Ph.D.
Toxicologic Pathologist
Assistant Pathology Program Manager
Integrated Laboratory Systems, Inc. Research Triangle Park, NC

Reviewers

Thomas J. Rosol, DVM, PhD, DACVP
Professor of Veterinary Biosciences
Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
The Ohio State University
Columbus, OH

Amy Brix, DVM, PhD, DACVP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC