Reproductive System, Male

Coagulating Gland - Atrophy

Narrative
Comment:
Atrophy of the coagulating gland consists of reduction in size of acini and of the lining epithelium. The ascinar reduction and/or collapse causes an increased prominence of the periacinar fibromuscular tissue. The lining epithelial cells are attenuated, and there may be reduction or absence of luminal secretory product. Atrophic changes may be age related and can be caused by castration or exposure to some hormonally active xenobiotics.
Recommendations:
Atrophy of the coagulating gland should be diagnosed and graded.
References:

Boorman GA, Elwell MR, Mitsumori K. 1990. Male accessory sex glands, penis, and scrotum. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 419-428.

Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563

Bosland MC, Tuomari DL, Elwell MR, Shirai T, Ward JM, McConnell RF. 1998. Proliferative lesions of the prostate and other accessory sex glands in male rats, URG-4. In: Guidelines for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC, 1-20.

Creasy D, Bube A, de Rijk E, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K, Rehm S, Rogerson P, Whitney K. 2012. Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol 40:40S-121S.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22949412

Markus RP, Goncalo MC, Lapa AJ. 1981. Castration atrophy and pharmacological reactivity of the rat coagulating gland. Braz J Med Res 14:181-185.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/6121593

Suwa T, Nyska A, Haseman JK, Mahler JF, Maronpot RR. 2002. Spontaneous lesions in control B6C3F1 mice and recommended sectioning of male accessory sex organs. Toxicol Pathol 30(2):228- 234.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11950166
  • Image of atrophy in the coagulating gland from a male B6C3F1 mouse in a chronic study

    Coagulating Gland - Atrophy. Atrophy of the coagulating gland in a male B6C3F1 mouse from a chronic study.

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Coagulating Gland - Atrophy. Atrophy of the coagulating gland in a male B6C3F1 mouse from a chronic study.
Coagulating Gland - Atrophy. Atrophy of the coagulating gland in a male B6C3F1 mouse from a chronic study.
Coagulating Gland - Atrophy. Atrophy of the coagulating gland in a male B6C3F1 mouse from a chronic study.
Coagulating Gland - Atrophy. Atrophy of the coagulating gland in a male B6C3F1 mouse from a chronic study.

Authors

Dianne M. Creasy, PhD, Dip RCPath, FRCPath
Dianne Creasy Consulting LLC
Pipersville, PA

Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Dipak K. Giri, DVM, PHD, DACVP
Toxicologic Pathologist
Integrated Laboratory Systems, Inc.
Research Triangle Park, NC

Reviewers

Mark F. Cesta, DVM, PhD, DACVP
Staff Scientist, NTP Pathologist
Cellular and Molecular Pathology Branch
Division of the National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC

David E. Malarkey DVM, PhD, DACVP, FIATP
Head, National Toxicology Program Pathology Group
Cellular and Molecular Pathology Branch
Division of the National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC