Cardiovascular System

Heart - Cardiomyopathy

    Heart - Cardiomyopathy in a male B6C3F1/N mouse from a chronic study. Branching bands of fibrous tissue and mononuclear inflammatory cells (arrows) separate cardiomyocytes.
    Heart - Cardiomyopathy in a female Harlan Sprague-Dawley rat from a chronic study. Note the large bands of fibrosis (arrows) and inflammatory cell infiltrates with loss of cardiomyocytes.
    Heart - Cardiomyopathy in a female F344/N rat from a subchronic study. This early lesion is composed primarily of inflammatory cells (arrow).
    Heart- Cardiomyopathy in a female F344/N rat from a subchronic study (higher magnification of Figure 3). This lesion is composed mainly of mononuclear inflammatory cells.


    Crystal L. Johnson, DVM, DACVP
    Veterinary Pathologist II
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel


    Brian Berridge, DVM, PhD, DACVP
    Director, WW Animal Research Strategy
    GlaxoSmithKline R&D
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC