Nervous System

Brain, Neuron - Cell Loss

    Narrative
    Neuronal cell loss in a female F344/N from a 2-year study. Note the loss of neurons in CA3 region of the hippocampus (arrows).
    Neuronal cell loss in a female F344/N from a 2-year study. Note the loss of neurons in CA3 region of the hippocampus (arrows).
    Normal number and morphology of CA3 neurons (arrow) in a control male rat from a single-dose acute gavage study.
    Normal number and morphology of CA3 neurons (arrow) in a control male rat from a single-dose acute gavage study.
    Normal number and morphology of CA3 neurons (arrow) in a control male rat from a single-dose acute gavage study.
    Normal number and morphology of CA3 neurons (arrow) in a control male rat from a single-dose acute gavage study.

    Authors 

    Peter Little, DVM, MS, PhD, DACVP
    Neuropathology Consultant
    Experimental Pathology Laboratories, Inc.  
    Research Triangle Park, NC

    Deepa B. Rao, BVSc, MS, PhD, DABT, DACVP
    NTP Pathologist (Contractor)
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Reviewers

    James P. Morrison, DVM, DACVP
    Scientific Director
    Charles River Laboratories, Pathology Associates
    Research Triangle Park, NC

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC