Alimentary System

Esophagus, Muscularis - Degeneration

    Narrative
    Esophagus, Muscularis - Degeneration in a male F344/N rat from a chronic study. Decreased muscle fiber size (arrow).
    Esophagus, Muscularis - Degeneration in a male F344/N rat from a chronic study. Decreased muscle fiber size (arrow).
    Esophagus, Muscularis - Degeneration in a male F344/N rat from a chronic study (higher magnification of Figure 1). Note the decreased muscle fiber size (arrow).
    Esophagus, Muscularis - Degeneration in a male F344/N rat from a chronic study (higher magnification of Figure 1). Note the decreased muscle fiber size (arrow).
    Esophagus, Muscularis - Degeneration in a female Sprague-Dawley rat from a chronic study. There are infiltrates of macrophages amid the muscle fibers (arrow).
    Esophagus, Muscularis - Degeneration in a female Sprague-Dawley rat from a chronic study. There are infiltrates of macrophages amid the muscle fibers (arrow).
    Esophagus, Muscularis - Degeneration in a male F344/N rat from a chronic study (higher magnification of Figure 3). There are infiltrates of macrophages amid the muscle fibers (arrow).
    Esophagus, Muscularis - Degeneration in a male F344/N rat from a chronic study (higher magnification of Figure 3). There are infiltrates of macrophages amid the muscle fibers (arrow).

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC