Spontaneously occurring cellular infiltrates are rare in thyroid glands of mice and rats. Multiple changes are present in the thyroids of these treated mice (Figure 1, Figure 2, and Figure 3). Lymphoid cell infiltrates are present between follicles (Figure 1 and Figure 2) and in perivascular spaces (Figure 3). Additionally there is hypertrophy, degeneration, and necrosis of follicular epithelium.
Greaves P. 2007. Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation, 3rd ed. Academic Press, Amsterdam, 819-839.Abstract: http://www.sciencedirect.com/science/book/9780444527714
Hardisty JF, Boorman GA. 1999. Thyroid and parathyroid glands. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 537–554.Abstract: http://www.cacheriverpress.com/books/pathmouse.htm