Alimentary System

Stomach, Glandular Stomach, Glands - Cyst

Narrative

Comment:

Cysts in the glandular stomach are usually found in the pyloric antrum, extend into the submucosa, and are lined by well-differentiated epithelial cells. Glandular cysts in the fundus occur with increased frequency as the animal ages and are present in virtually all rats older than 15 months. The cysts are lined by cuboidal to flattened chief, parietal, or mucous cells. The lumen contains mucus or mixed inflammatory exudates. Occasionally cysts are surrounded by fibrosis and chronic inflammatory infiltrates. Glandular cysts are frequently associated with mineralized deposits in aged rats. Glandular cysts are differentiated from glandular dilation, as the cysts are usually solitary, larger, and lined by attenuated epithelium, whereas glandular dilation usually involves multiple glands and the dilatation is often irregular in profile, that is, does not have a well-circumscribed circular structure (see Stomach, Glandular Stomach - Glands - Dilation ). Cysts are less likely to be associated with treatment than is glandular dilation.

Recommendations:

Cysts should be diagnosed but typically are not graded.

Related Links:

Stomach, Glandular Stomach - Glands - Dilation

References:

Bertram TA, Markovits JE, Juliana MM. 1996. Non-proliferative lesions of the alimentary canal in rats GI-1. In Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC, 1-16.

Full Text: https://www.toxpath.org/docs/SSNDC/GINonproliferativeRat.pdf

Brown HR, Hardisty JF. 1990. Oral cavity, esophagus and stomach. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 9-30.

Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563

Frantz JD, Betton GR, Cartwright ME, Crissman JW, Macklin AW, Maronpot RR. 1991. Proliferative lesions of the non-glandular and glandular stomach in rats GI-3. In Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC, 1-20.

Full Text: https://www.toxpath.org/docs/SSNDC/StomachProliferativeRat.pdf

National Toxicology Program. 1988. NTP TR-336. Toxicology and Carcinogenesis Studies of Penicillin VK (CAS No. 132-98-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.

Abstract: https://ntp.niehs.nih.gov/go/8907

National Toxicology Program. 2000. NTP TR-491. Toxicology and Carcinogenesis Studies of Methyleugenol (CAS No. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.

Abstract: https://ntp.niehs.nih.gov/go/10172

National Toxicology Program. 2010. NTP TR-558. Toxicology and Carcinogenesis Studies of 3,3’,4,4’-Tetrachloroazobenzene (TCAB) (CAS No. 14047-09-7) in Harlan Sprague Dawley Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.

Abstract: https://ntp.niehs.nih.gov/go/33564

All Images

Stomach, Glandular stomach, Glands - Cyst in a male B6C3F1 mouse from a subchronic study. This cystic gland is lined by slightly flattened epithelium.

Authors and Reviewers

Authors:

Linda H. Kooistra, DVM, PhD, DACVP
Pathologist
Charles River Laboratories, Inc.
Research Triangle Park, NC

Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
Expert in Toxicologic Pathology
Visiting Full Professor of Pathology
Sackler School of Medicine, Tel Aviv University Timrat Israel

Reviewers:

Joel R. Leininger, DVM, PhD
Senior Pathologist
MedImmune
Washington, DC

Amy Brix, DVM, PhD, DACVP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC