Endocrine System

Parathyroid Gland - Fibrosis

Narrative

Comment:

Parathyroid fibrosis is characterized by fibrillar, eosinophilic material that expands the interstitium of the parathryorid gland and, when severe, replaces the parenchyma. It is a rarely seen change. There may be extension into the adjacent thyroid parenchyma. The significance of this lesion is uncertain.

Recommendations:

Rare lesions such as this should be diagnosed and given a severity grade.

References:

References not listed.

All Images

Parathyroid Gland - Fibrosis in a female F344/N rat from a chronic study. Extensive fibrosis has replaced the parathyroid parenchyma and extended into the thyroid.

Parathyroid Gland - Fibrosis in a female F344/N rat from a chronic study. Higher magnification of Figure 1 showing mature collagen surrounding remaining compressed chords of parathyroid parenchymal cells.

Authors and Reviewers

Authors

Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Georgette D. Hill, D.V.M., Ph.D.
Toxicologic Pathologist/Assistant Pathology Program Manager
Comparative Molecular Pathology Division
Integrated Laboratory Systems, Inc.
Research Triangle Park, NC

Reviewers

Thomas J. Rosol, DVM, PhD, DACVP
Professor of Veterinary Biosciences
Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
The Ohio State University
Columbus, OH

Amy Brix, DVM, PhD, DACVP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC