Respiratory System

Nose, Epithelium - Hyperplasia

    Narrative
    Nose, Respiratory epithelium - Normal in a male B6C3F1/N mouse from a subchronic study. The normal respiratory epithelium on the nasal septum is presented for comparison with Figures 2-7.
    Nose, Respiratory epithelium - Normal in a male B6C3F1/N mouse from a subchronic study. The normal respiratory epithelium on the nasal septum is presented for comparison with Figures 2-7.
    Nose, Respiratory epithelium - Hyperplasia in a female B6C3F1/N mouse from a chronic study. Minimal thickening and folding of the surface epithelium is present, with some nuclear crowding and pleomorphism.
    Nose, Respiratory epithelium - Hyperplasia in a female B6C3F1/N mouse from a chronic study. Minimal thickening and folding of the surface epithelium is present, with some nuclear crowding and pleomorphism.
    Nose, Respiratory epithelium - Hyperplasia in a female Harlan Sprague-Dawley rat from a chronic study. The thickened proliferative epithelial surface is arranged in regular folds.
    Nose, Respiratory epithelium - Hyperplasia in a female Harlan Sprague-Dawley rat from a chronic study. The thickened proliferative epithelial surface is arranged in regular folds.
    Nose, Respiratory epithelium - Hyperplasia in a male B6C3F1/N mouse from a chronic study. Proliferation of the epithelial cells resulted in thickening of the epithelium, with folding and invagination into the lamina propria forming pseudoglands. A concretion (arrow) is present within one of the pseudoglands.
    Nose, Respiratory epithelium - Hyperplasia in a male B6C3F1/N mouse from a chronic study. Proliferation of the epithelial cells resulted in thickening of the epithelium, with folding and invagination into the lamina propria forming pseudoglands. A concretion (arrow) is present within one of the pseudoglands.
    Nose, Respiratory epithelium - Hyperplasia in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 4). Infolding or invagination of the hyperplastic epithelium forms pseudoglands. A concretion is present within a pseudogland (arrow).
    Nose, Respiratory epithelium - Hyperplasia in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 4). Infolding or invagination of the hyperplastic epithelium forms pseudoglands. A concretion is present within a pseudogland (arrow).
    Nose, Transitional epithelium - Hyperplasia in a male F344/N rat from a chronic study. Numbers of superficial epithelial cells are increased, and a focal downgrowth of basal epithelial cells extends into the lamina propria (arrow). Goblet cells are also increased, which may be better termed "goblet cell metaplasia.", basic_html
    Nose, Transitional epithelium - Hyperplasia in a male F344/N rat from a chronic study. Numbers of superficial epithelial cells are increased, and a focal downgrowth of basal epithelial cells extends into the lamina propria (arrow). Goblet cells are also increased, which may be better termed "goblet cell metaplasia.", basic_html
    Nose, Olfactory epithelium - Hyperplasia in a male B6C3F1/N mouse from a chronic study. There is proliferative thickening of the olfactory epithelial mucosa (arrow).
    Nose, Olfactory epithelium - Hyperplasia in a male B6C3F1/N mouse from a chronic study. There is proliferative thickening of the olfactory epithelial mucosa (arrow).

    Authors

    Rodney A. Miller, DVM, PhD, DACVP
    NC Pathology Group Manager
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Ronald Herbert, DVM, PhD
    NTP Pathologist
    Group Leader, Pathology Support Group
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC