Urinary System

Urinary Bladder - Calculus/Crystal

    Narrative
    A calculus (asterisk) fills the entire bladder lumen from a male F344/N rat in a chronic study.
    A calculus (asterisk) fills the entire bladder lumen from a male F344/N rat in a chronic study.
    Hyperplasia of the urothelium (arrow) due to the presence of the calculus, from a male F344/N rat in a chronic study.
    Hyperplasia of the urothelium (arrow) due to the presence of the calculus, from a male F344/N rat in a chronic study.
    A small basophilic calculus (arrow) associated with chronic inflammation and urothelial hyperplasia, from a female Harlan Sprague-Dawley rat in a chronic study.
    A small basophilic calculus (arrow) associated with chronic inflammation and urothelial hyperplasia, from a female Harlan Sprague-Dawley rat in a chronic study.

    Authors

    John Curtis Seely, DVM, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska,  DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University
    Timrat Israel

    Reviewers

    Samuel M Cohen, PHD, MD
    Professor
    Havlik-Wall Professor of Oncology
    Director of Pathology Residency Program
    Nebraska Medical Center
    Omaha, NE

    David E. Malarkey DVM, PhD, DACVP, FIATP
    Head, National Toxicology Program Pathology Group
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC