Immune System

Spleen - Hyperplasia, Mast Cell

    Narrative
    Spleen - Hyperplasia, Mast cell in a female B6C3F1/N mouse from a chronic study. Multifocal aggregates of mast cells (arrows) are present within the splenic red pulp.
    Spleen - Hyperplasia, Mast cell in a female B6C3F1/N mouse from a chronic study. Multifocal aggregates of mast cells (arrows) are present within the splenic red pulp.
    Spleen - Hyperplasia, Mast cell in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). Clusters of well-differentiated mast cells (arrows) are intermixed with other red pulp cellular components.
    Spleen - Hyperplasia, Mast cell in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). Clusters of well-differentiated mast cells (arrows) are intermixed with other red pulp cellular components.

    Authors

    Kristen Hobbie, DVM, PhD
    Principal Pathologist
    Huntingdon Life Sciences
    Peterborough, UK

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Holly M. Kolenda-Roberts, DVM, PhD, DACVP
    Veterinary Pathologist
    SNBL USA
    Everett, WA

    Reviewers

    Jerrold M. Ward, DVM, PhD, DACVP, FIATP
    Veterinary Pathologist
    Global VetPathology
    Montgomery Village, MD

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC