Immune System

Lymph Node - Necrosis

    Narrative
    Lymph node - Necrosis in a treated male Harlan Sprague-Dawley rat from a subchronic study. A central focus of necrotic cellular debris (arrow) is evident.
    Lymph node - Necrosis in a treated male Harlan Sprague-Dawley rat from a subchronic study. A central focus of necrotic cellular debris (arrow) is evident.
    Lymph node - Necrosis in a treated male Harlan Sprague-Dawley rat from a subchronic study (higher magnification of Figure 1). The necrosis (arrow) is surrounded by a mixed inflammatory infiltrate with fibrous connective tissue (arrowhead).
    Lymph node - Necrosis in a treated male Harlan Sprague-Dawley rat from a subchronic study (higher magnification of Figure 1). The necrosis (arrow) is surrounded by a mixed inflammatory infiltrate with fibrous connective tissue (arrowhead).

    Authors

    Kristen Hobbie, DVM, PhD
    Principal Pathologist
    Huntingdon Life Sciences
    Peterborough, UK

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Holly M. Kolenda-Roberts, DVM, PhD, DACVP
    Veterinary Pathologist
    SNBL USA
    Everett, WA

    Reviewers

    Jerrold M. Ward, DVM, PhD, DACVP, FIATP
    Veterinary Pathologist
    Global VetPathology
    Montgomery Village, MD

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC