Immune System

Lymph Node - Atrophy

    Narrative
    Lymph node - Atrophy in a female F344/N rat from a subchronic study. With early lymph node atrophy, paracortical lymphocytes are depleted (arrow), and number and size of follicles are decreased (arrowhead).
    Lymph node - Atrophy in a female F344/N rat from a subchronic study. With early lymph node atrophy, paracortical lymphocytes are depleted (arrow), and number and size of follicles are decreased (arrowhead).
    Lymph node - Atrophy in a female F344/N rat from a subchronic study (higher magnification of Figure 1). High endothelial venules (arrows) may be more prominent with lymphocyte depletion.
    Lymph node - Atrophy in a female F344/N rat from a subchronic study (higher magnification of Figure 1). High endothelial venules (arrows) may be more prominent with lymphocyte depletion.

    Authors

    Kristen Hobbie, DVM, PhD
    Principal Pathologist
    Huntingdon Life Sciences
    Peterborough, UK

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Holly M. Kolenda-Roberts, DVM, PhD, DACVP
    Veterinary Pathologist
    SNBL USA
    Everett, WA

    Reviewers

    Jerrold M. Ward, DVM, PhD, DACVP, FIATP
    Veterinary Pathologist
    Global VetPathology
    Montgomery Village, MD

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC