Nervous System
Brain, Neuron - Necrosis
Narrative

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Figure 5


Necrosis of small neurons, such as the granule cells of the olfactory bulb and dentate gyrus and the internal granule cell layer of the cerebellum, is characterized by basophilic nuclear pyknosis with hematoxylin and eosin staining. In Figure 6




Mineralization of necrotic tissue, including brain cells, occurs over time. Where mineral deposits encrust a recognizable cell or its dendritic terminal boutons, it is important for the pathologist to recognize this chronologic feature of degenerated cells in brain and to differentiate it from yeast or mycotic hyphae with which it may be confused.
Mena H, Cadavid D, Rushing EJ. 2004. Human cerebral infarct: A proposed histopathologic classification based on 137 cases. Acta Neuropathol 108:524-530.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/15517310Schmued LC, Hopkins KJ, Fluoro-Jade B. 2000. A high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res 874:123-130.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/10960596Schmued LC, Stowers CC, Scallet AC, Xu L. 2005. Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons. Brain Res 1035:24-31.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/15713273Neuronal necrosis in a male F344 rat from an acute inhalation study. The black arrow identifies acute eosinophilic necrosis. By contrast, the red arrow identifies a relatively normal neuron, and the arrowhead identifies a pyknotic nucleus amid associated vacuolation of the neuropil.
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