Reproductive System, Male

Testis, Seminiferous Tubule - Giant Cells

    Narrative
    Testis, Seminiferous tubule - Giant cells in a male B6C3F1 mouse from a subchronic study. These cells are associated with germ cell degeneration.
    Testis, Seminiferous tubule - Giant cells in a male F344/N rat from a chronic study. These cells are associated with germ cell degeneration.
    Testis, Seminiferous tubule - Giant cells in a male Harlan Sprague-Dawley rat. These cells represent spermatocytes that have coalesced into individual syncytial cells. (Photograph courtesy of Dr. D. Creasy.)
    Testis, Seminiferous tubule - Giant cells in a male Harlan Sprague-Dawley rat. A multinucleated giant cell (arrow) formed by fusion of round spermatids. (Photograph courtesy of Dr. D. Creasy.)

    Authors

    Dianne M. Creasy, PhD, Dip RCPath, FRCPath
    Dianne Creasy Consulting LLC
    Pipersville, PA

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Dipak K. Giri, DVM, PHD, DACVP
    Toxicologic Pathologist
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Reviewers

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    David E. Malarkey DVM, PhD, DACVP, FIATP
    Head, National Toxicology Program Pathology Group
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC