Endocrine System

Thyroid Gland, Follicle - Mineralization

Narrative

Comment:

Mineralization within solitary thyroid follicles is occasionally seen in adults and may appear as granular basophilic deposits not associated with inflammation.

Recommendations:

Mineralization in the thyroid follicles is an incidental finding and should be documented and given a severity grade only when severe or suspected of being treatment related.

References:

References not listed.

All Images

Thyroid gland, Follicle - Mineralization in a male F344/N rat from a chronic study. There is focal mineralization within the colloid of two follicles.

Thyroid gland, Follicle - Mineralization in a male F344/N rat from a chronic study. Higher magnification of Figure 1 Shows the focal mineral deposits in more detail.

Authors and Reviewers

Authors

Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Amy Brix, DVM, PhD, DACVP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Reviewers

Thomas J. Rosol, DVM, PhD, DACVP
Professor of Veterinary Biosciences
Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
The Ohio State University
Columbus, OH

Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
Staff Scientist, NTP Pathologist
NTP Pathology Group
National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC