Hematopoietic System

Bone Marrow - Hypercellularity

    Narrative
    Bone marrow in a control female F344 rat from a subchronic study.
    Bone marrow in a control female F344 rat from a subchronic study.
    Bone marrow in a treated female F344/N rat from a subchronic study. Compared with the concurrent control (Figure 1), there is erythroid hypercellularity in response to a treatment-related anemia.
    Bone marrow in a treated female F344/N rat from a subchronic study. Compared with the concurrent control (Figure 1), there is erythroid hypercellularity in response to a treatment-related anemia.
    Bone marrow in a control female F344/N rat from a subchronic study (higher magnification of Figure 1).
    Bone marrow in a control female F344/N rat from a subchronic study (higher magnification of Figure 1).
    Bone marrow in a treated female F344/N rat from a subchronic study (higher magnification of Figure 2). Compared with the concurrent control (Figure 3), there is erythroid hypercellularity in response to a treatment-related anemia.
    Bone marrow in a treated female F344/N rat from a subchronic study (higher magnification of Figure 2). Compared with the concurrent control (Figure 3), there is erythroid hypercellularity in response to a treatment-related anemia.
    Hypercellular bone marrow in a male B6C3F1 mouse from a chronic study.
    Hypercellular bone marrow in a male B6C3F1 mouse from a chronic study.

    Authors

    Michelle C. Cora, DVM, DACVP
    Veterinary Medical Officer
    NTP Clinical Pathologist
    NTP Clinical Pathology Group
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Gregory Travlos, DVM, DACVP
    Group Leader, Clinical Pathology Group
    Cellular and Molecular Pathology Branch
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Armando R. Irizarry, DVM, PHD, DACVP
    Adjunct Associate Professor of Veterinary Anatomic and Clinical Pathology
    Department of Comparative Pathobiology
    Purdue University College of Veterinary Medicine
    West Lafayette, IN

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC