Integumentary System

Skin - Necrosis

    Narrative
    Epithelial necrosis-shrunken keratinocytes with hypereosinophilic cytoplasm and condensed nuclei (arrows) in a male F344/N rat from a 90-day study.
    Epithelial necrosis-shrunken keratinocytes with hypereosinophilic cytoplasm and condensed nuclei (arrows) in a male F344/N rat from a 90-day study.
    Epithelial necrosis-shrunken keratinocytes with hypereosinophilic cytoplasm (arrows) in a male F344/N rat from a 90-day study.
    Epithelial necrosis-shrunken keratinocytes with hypereosinophilic cytoplasm (arrows) in a male F344/N rat from a 90-day study.
    Epithelial necrosis in a male F344/N rat from a 90-day study-in severe cases, necrosis of the epithelium may extend into the hair follicles.
    Epithelial necrosis in a male F344/N rat from a 90-day study-in severe cases, necrosis of the epithelium may extend into the hair follicles.
    Epithelial necrosis in a male F344/N rat from a 90-day study-in severe cases, necrosis of the epithelium may extend into the hair follicles.
    Epithelial necrosis in a male F344/N rat from a 90-day study-in severe cases, necrosis of the epithelium may extend into the hair follicles.
    Skin necrosis-transmural necrosis of the epidermis, dermis, and subcutis in a male B6C3F1 mouse from a 90-day study.
    Skin necrosis-transmural necrosis of the epidermis, dermis, and subcutis in a male B6C3F1 mouse from a 90-day study.
    Skin necrosis-transmural necrosis of the epidermis, dermis, and subcutis in a male B6C3F1 mouse from a 90-day study.
    Skin necrosis-transmural necrosis of the epidermis, dermis, and subcutis in a male B6C3F1 mouse from a 90-day study.

    Authors

    Molly H. Boyle, DVM, MPH, DACVP
    Toxicologic Pathologist
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Georgette D. Hill, D.V.M., Ph.D.
    Toxicologic Pathologist
    Assistant Pathology Program Manager
    Integrated Laboratory Systems, Inc. Research Triangle Park, NC

    Reviewers

    Michael R. Elwell, DVM, PhD, DACVP
    Anatomic Pathologist
    Covance Laboratories, Inc.
    Washington, D.C.

    David E. Malarkey DVM, PhD, DACVP, FIATP
    Head, National Toxicology Program Pathology Group
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC