Integumentary System
Skin - Necrosis
Narrative




Skin necrosis (Figure 5


Whenever present, the incidence of skin necrosis should be documented and assigned a severity grade. Dystrophic mineralization need not be diagnosed separately but should be described in the pathology narrative. Metastatic mineralization should be diagnosed whenever present, assigned a severity grade, and described in the pathology narrative. Fat necrosis (i.e., limited to the subcutis) should be diagnosed, graded, and described as a sporadic background finding in the narrative as “Skin, Subcutis – Necrosis.”
Elwell MR, Stedman MA, Kovatch RM. 1990. Skin and subcutis. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 261-277.
Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563Klein-Szanto AJP, Conti CJ. 2002. Skin and oral mucosa. In: Handbook of Toxicologic Pathology, 2nd ed (Haschek WM, Rousseaux CG, Wallig MA, eds). Academic Press, San Diego, 2:85-116.
Abstract: http://www.sciencedirect.com/science/book/9780123302151Peckham JC, Heider K. 1999. Skin and subcutis. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 555-612.
Abstract: http://www.cacheriverpress.com/books/pathmouse.htmEpithelial necrosis-shrunken keratinocytes with hypereosinophilic cytoplasm and condensed nuclei (arrows) in a male F344/N rat from a 90-day study.