Cardiovascular System

Heart, Myocardium - Necrosis

    Narrative
    Heart, Myocardium - Necrosis in a male P16Ink4a/p19Arf (background: 80% C57BL/6, 19% 129/Sv, 1% SJL) mouse from an acute study. Myocardial necrosis (arrows) manifests as areas of pallor in the myocardium.
    Heart, Myocardium - Necrosis in a male P16Ink4a/p19Arf (background: 80% C57BL/6, 19% 129/Sv, 1% SJL) mouse from an acute study. Myocardial necrosis (arrows) manifests as areas of pallor in the myocardium.
    Heart, Myocardium - Necrosis in a male P16Ink4a/p19Arf (background: 80% C57BL/6, 19% 129/Sv, 1% SJL) mouse from an acute study (higher magnification of Figure 1). Loss of cellular detail is apparent in the areas of pallor (arrows).
    Heart, Myocardium - Necrosis in a male P16Ink4a/p19Arf (background: 80% C57BL/6, 19% 129/Sv, 1% SJL) mouse from an acute study (higher magnification of Figure 1). Loss of cellular detail is apparent in the areas of pallor (arrows).
    Heart, Myocardium - Necrosis in a male B6C3F1/N mouse from a subchronic study. Areas in the myocardium show loss of cellular and nuclear detail (arrows).
    Heart, Myocardium - Necrosis in a male B6C3F1/N mouse from a subchronic study. Areas in the myocardium show loss of cellular and nuclear detail (arrows).
    Heart, Myocardium - Necrosis in a male P16(ink4a)/(+/-)(C57BL/6) mouse from an acute study. The myocardium has coalescing areas with loss of cells (arrows).
    Heart, Myocardium - Necrosis in a male P16(ink4a)/(+/-)(C57BL/6) mouse from an acute study. The myocardium has coalescing areas with loss of cells (arrows).
    Heart, Myocardium - Necrosis in a male P16Ink4a/p19Arf (background: 80% C57BL/6, 19% 129/Sv, 1% SJL) mouse from an acute study (higher magnification of Figure 4). There is loss of cellular detail (arrows) and a small area of hemorrhage.
    Heart, Myocardium - Necrosis in a male P16Ink4a/p19Arf (background: 80% C57BL/6, 19% 129/Sv, 1% SJL) mouse from an acute study (higher magnification of Figure 4). There is loss of cellular detail (arrows) and a small area of hemorrhage.
    Heart, Myocardium - Necrosis in a male B6C3F1/N mouse from a chronic study. A well-demarcated region of myocardial necrosis (infarct) is present in the interventricular septum (arrows).
    Heart, Myocardium - Necrosis in a male B6C3F1/N mouse from a chronic study. A well-demarcated region of myocardial necrosis (infarct) is present in the interventricular septum (arrows).
    Heart, Myocardium - Necrosis in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 6). The pale, necrotic area (infarct) at the lower right and the normal myocardium (upper left) are separated by asterisks.
    Heart, Myocardium - Necrosis in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 6). The pale, necrotic area (infarct) at the lower right and the normal myocardium (upper left) are separated by asterisks.

    Authors:

    Crystal L. Johnson, DVM, DACVP
    Veterinary Pathologist II
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Brian Berridge, DVM, PhD, DACVP
    Director, WW Animal Research Strategy
    GlaxoSmithKline R&D
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC