Respiratory System

Lung - Fibrosis

    Narrative
    Lung - Fibrosis in a mouse. The airspaces have been obliterated at the tip of the lung lobe (arrow).
    Lung - Fibrosis in a mouse. The airspaces have been obliterated at the tip of the lung lobe (arrow).
    Lung - Fibrosis in a mouse (same animal as in Figure 1). The blue staining indicates interstitial fibrosis. Masson's trichrome stain., basic_html
    Lung - Fibrosis in a mouse (same animal as in Figure 1). The blue staining indicates interstitial fibrosis. Masson's trichrome stain., basic_html
    Lung - Fibrosis in a male F344/N rat from a chronic study. Severe interstitial fibrosis replaces the lung parenchyma.
    Lung - Fibrosis in a male F344/N rat from a chronic study. Severe interstitial fibrosis replaces the lung parenchyma.
    Lung, Bronchiole - Fibrosis in a female F344/N rat in a subchronic study. There is intraluminal and mural bronchiolar fibrosis.
    Lung, Bronchiole - Fibrosis in a female F344/N rat in a subchronic study. There is intraluminal and mural bronchiolar fibrosis.
    Lung, Bronchus - Fibrosis in a male B6C3F1/N mouse from a chronic study. There is multifocal subepithelial bronchial fibrosis (arrow).
    Lung, Bronchus - Fibrosis in a male B6C3F1/N mouse from a chronic study. There is multifocal subepithelial bronchial fibrosis (arrow).
    Lung, Bronchus - Fibrosis in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 5). There is a focus of mature subepithelial bronchial fibrosis with epithelial atrophy.
    Lung, Bronchus - Fibrosis in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 5). There is a focus of mature subepithelial bronchial fibrosis with epithelial atrophy.
    Lung, Pleura - Fibrosis in a female B6C3F1/N mouse from a chronic study. The pleura is thickened by fibrosis and inflammation.
    Lung, Pleura - Fibrosis in a female B6C3F1/N mouse from a chronic study. The pleura is thickened by fibrosis and inflammation.
    Lung, Pleura - Fibrosis in a female B6C3F1/N mouse from a chronic study. The pleura is diffusely thickened by fibrosis and inflammation.
    Lung, Pleura - Fibrosis in a female B6C3F1/N mouse from a chronic study. The pleura is diffusely thickened by fibrosis and inflammation.

    Authors

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist/NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Darlene Dixon, DVM, PhD, DACVP
    Group Leader
    Molecular Pathogenesis Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Ronald A. Herbert, DVM, PhD
    Group Leader/NTP Pathologist
    Pathology Support Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Lauren M. Staska, DVM, PhD, DACVP
    Senior Pathologist
    WIL Research
    Hillsborough, NC

    Reviewers

    Gary A. Boorman, DVM, PhD, DACVP, DABT, DACLAM
    Pathologist
    Covance Laboratories, Inc.
    Chantilly, VA

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC