Respiratory System

Lung - Amyloid

    Narrative
    Lung - Amyloid in a female B6C3F1/N mouse from a chronic study. There is perivascular and peribronchiolar amyloid deposition (arrows).
    Lung - Amyloid in a female B6C3F1/N mouse from a chronic study. There is perivascular and peribronchiolar amyloid deposition (arrows).
    Lung - Amyloid in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). There is perivascular and peribronchiolar, acellular, eosinophilic material (arrows).
    Lung - Amyloid in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). There is perivascular and peribronchiolar, acellular, eosinophilic material (arrows).
    Lung - Amyloid in a male B6C3F1/N mouse from a chronic study. There is deposition of amyloid in the vascular wall (arrows).
    Lung - Amyloid in a male B6C3F1/N mouse from a chronic study. There is deposition of amyloid in the vascular wall (arrows).
    Lung - Amyloid in a male B6C3F1/N mouse from a chronic study. Acellular, eosinophilic material (amyloid) is present in the vessel wall (arrow).
    Lung - Amyloid in a male B6C3F1/N mouse from a chronic study. Acellular, eosinophilic material (amyloid) is present in the vessel wall (arrow).

    Authors

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist/NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Darlene Dixon, DVM, PhD, DACVP
    Group Leader
    Molecular Pathogenesis Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Ronald A. Herbert, DVM, PhD
    Group Leader/NTP Pathologist
    Pathology Support Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Lauren M. Staska, DVM, PhD, DACVP
    Senior Pathologist
    WIL Research
    Hillsborough, NC

    Reviewers

    Gary A. Boorman, DVM, PhD, DACVP, DABT, DACLAM
    Pathologist
    Covance Laboratories, Inc.
    Chantilly, VA

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC