Musculoskeletal System

Skeletal Muscle - Inflammation

    Narrative
    Skeletal muscle - Inflammation, Acute in a female Swiss CD-1 mouse from a chronic study. A neutrophilic infiltrate has led to necrosis and loss of muscle fibers.
    Skeletal muscle - Inflammation, Acute in a female Swiss CD-1 mouse from a chronic study. A neutrophilic infiltrate has led to necrosis and loss of muscle fibers.
    Skeletal muscle - Inflammation, Acute in a female Swiss CD-1 mouse from a chronic study (higher magnification of Figure 1). There is loss of muscle fibers and a hypereosinophilic degenerative fiber (arrow).
    Skeletal muscle - Inflammation, Acute in a female Swiss CD-1 mouse from a chronic study (higher magnification of Figure 1). There is loss of muscle fibers and a hypereosinophilic degenerative fiber (arrow).
    Skeletal muscle - Inflammation, Suppurative in a male B6C3F1/N mouse from a chronic study. A localized collection of intact and degenerating neutrophils is present in the muscle.
    Skeletal muscle - Inflammation, Suppurative in a male B6C3F1/N mouse from a chronic study. A localized collection of intact and degenerating neutrophils is present in the muscle.
    Skeletal muscle - Inflammation, Suppurative in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 3). There is a localized collection of intact and degenerating neutrophils, as well as early neutrophilic infiltration between adjacent muscle fibers.
    Skeletal muscle - Inflammation, Suppurative in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 3). There is a localized collection of intact and degenerating neutrophils, as well as early neutrophilic infiltration between adjacent muscle fibers.
    Skeletal muscle -Inflammation, Chronic in a female F344/N rat from a chronic study. A mixed mononuclear cellular response is associated with degeneration and loss of muscle fibers.
    Skeletal muscle -Inflammation, Chronic in a female F344/N rat from a chronic study. A mixed mononuclear cellular response is associated with degeneration and loss of muscle fibers.
    Skeletal muscle - Inflammation, Chronic in a female F344/N rat from a chronic study (higher magnification of Figure 5).
    Skeletal muscle - Inflammation, Chronic in a female F344/N rat from a chronic study (higher magnification of Figure 5).
    Skeletal muscle - Inflammation, Granulomatous in a male Sprague Dawley rat from a subchronic study. A mixture of mononuclear cells, along with multinucleated giant cells, has replaced muscle fibers, and muscle fiber degeneration and mineralization within multinucleated giant cells (arrows) can be seen in the area of inflammation.
    Skeletal muscle - Inflammation, Granulomatous in a male Sprague Dawley rat from a subchronic study. A mixture of mononuclear cells, along with multinucleated giant cells, has replaced muscle fibers, and muscle fiber degeneration and mineralization within multinucleated giant cells (arrows) can be seen in the area of inflammation.
    Skeletal muscle - Inflammation, Chronic-active in a male Tg.Ac (FVB/N) homozygous mouse from a subchronic study. A circumscribed area of granulomatous inflammation with multinucleated giant cells (arrow) and neutrophils within an extensive area of chronic-active inflammation surrounds a foreign body consistent with plant material.
    Skeletal muscle - Inflammation, Chronic-active in a male Tg.Ac (FVB/N) homozygous mouse from a subchronic study. A circumscribed area of granulomatous inflammation with multinucleated giant cells (arrow) and neutrophils within an extensive area of chronic-active inflammation surrounds a foreign body consistent with plant material.

    Authors

    Torrie A. Crabbs, DVM, DACVP
    Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC  

    Reviewers

    Philip H. Long, DVM, PhD, DACVP
    Presiden and Senior Pathologist
    Vet Path Services, Inc.
    Mason, OH

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC