Respiratory System

Lung - Metaplasia, Osseous

    Narrative
    Lung - Metaplasia, Osseous in a F344/N rat from a chronic study. A focus of unmineralized bone is present in the lung parenchyma.
    Lung - Metaplasia, Osseous in a F344/N rat from a chronic study. A focus of unmineralized bone is present in the lung parenchyma.
    Lung - Metaplasia, Osseous in a F344/N rat from a chronic study (higher magnification of Figure 1). The eosinophilic material in the lung is unmineralized bone.
    Lung - Metaplasia, Osseous in a F344/N rat from a chronic study (higher magnification of Figure 1). The eosinophilic material in the lung is unmineralized bone.
    Lung - Metaplasia, Osseous in a male F344/N rat from a subchronic study. A focus of mineralized bone is present in the lung parenchyma.
    Lung - Metaplasia, Osseous in a male F344/N rat from a subchronic study. A focus of mineralized bone is present in the lung parenchyma.
    Lung - Metaplasia, Osseous in a female B6C3F1/N mouse from a chronic study. There is a subpleural focus of mineralized bone within a focus of unmineralized bone.
    Lung - Metaplasia, Osseous in a female B6C3F1/N mouse from a chronic study. There is a subpleural focus of mineralized bone within a focus of unmineralized bone.
    Lung - Metaplasia, Osseous from a male Wistar Han rat in a chronic study. Though this focus of osseous metaplasia (arrow) is within an area of inflammation, it is likely not treatment related.
    Lung - Metaplasia, Osseous from a male Wistar Han rat in a chronic study. Though this focus of osseous metaplasia (arrow) is within an area of inflammation, it is likely not treatment related.
    Lung - Metaplasia, Osseous in a female F344/N rat from a chronic study. A focus of mineralized bone is present in the peripheral lung.
    Lung - Metaplasia, Osseous in a female F344/N rat from a chronic study. A focus of mineralized bone is present in the peripheral lung.

    Authors

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist/NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Darlene Dixon, DVM, PhD, DACVP
    Group Leader
    Molecular Pathogenesis Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Ronald A. Herbert, DVM, PhD
    Group Leader/NTP Pathologist
    Pathology Support Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Lauren M. Staska, DVM, PhD, DACVP
    Senior Pathologist
    WIL Research
    Hillsborough, NC

    Reviewers

    Gary A. Boorman, DVM, PhD, DACVP, DABT, DACLAM
    Pathologist
    Covance Laboratories, Inc.
    Chantilly, VA

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC