Immune System

Spleen, Red Pulp - Hyperplasia, Stromal

    Narrative
    Spleen, Red pulp - Hyperplasia, Stromal cell in a female F344/N rat from a chronic study. Intersecting, irregular bundles and bands of stromal cells (arrow) infiltrate the splenic red pulp.
    Spleen, Red pulp - Hyperplasia, Stromal cell in a female F344/N rat from a chronic study. Intersecting, irregular bundles and bands of stromal cells (arrow) infiltrate the splenic red pulp.
    Spleen, Red pulp - Hyperplasia, Stromal cell in a female F344/N rat from a chronic study. Stromal cells (arrows) are spindle to polygonal in shape and have eosinophilic cytoplasm and ovoid nuclei with euchromatic chromatin.
    Spleen, Red pulp - Hyperplasia, Stromal cell in a female F344/N rat from a chronic study. Stromal cells (arrows) are spindle to polygonal in shape and have eosinophilic cytoplasm and ovoid nuclei with euchromatic chromatin.
    Spleen, Red pulp - Hyperplasia, Stromal cell in a female F344/N rat from a chronic study. Intersecting, irregular bundles and bands of stromal cells (arrows) infiltrate the splenic red pulp.
    Spleen, Red pulp - Hyperplasia, Stromal cell in a female F344/N rat from a chronic study. Intersecting, irregular bundles and bands of stromal cells (arrows) infiltrate the splenic red pulp.
    Spleen, Red pulp - Hyperplasia, Stromal cell in a female F344/N rat from a chronic study. Stromal cells (arrows) are spindle to polygonal in shape and have eosinophilic cytoplasm and ovoid nuclei with euchromatic chromatin and a single nucleolus.
    Spleen, Red pulp - Hyperplasia, Stromal cell in a female F344/N rat from a chronic study. Stromal cells (arrows) are spindle to polygonal in shape and have eosinophilic cytoplasm and ovoid nuclei with euchromatic chromatin and a single nucleolus.

    Authors

    Kristen Hobbie, DVM, PhD
    Principal Pathologist
    Huntingdon Life Sciences
    Peterborough, UK

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Holly M. Kolenda-Roberts, DVM, PhD, DACVP
    Veterinary Pathologist
    SNBL USA
    Everett, WA

    Reviewers

    Jerrold M. Ward, DVM, PhD, DACVP, FIATP
    Veterinary Pathologist
    Global VetPathology
    Montgomery Village, MD

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC