Urinary System

Renal Tubule - Atypical Tubule Hyperplasia

    Narrative
    Kidney, Renal tubule - Atypical tubule hyperplasia in a male F344/N rat from a chronic study. Atypical tubule hyperplasia is confined to one tubule and is characterized by an increase in cellularity and cell size, cytoplasmic basophilia, nuclear enlargement, and circumferential expansion.
    Kidney, Renal tubule - Atypical tubule hyperplasia in a male F344/N rat from a chronic study. Atypical tubule hyperplasia is confined to one tubule and is characterized by an increase in cellularity and cell size, cytoplasmic basophilia, nuclear enlargement, and circumferential expansion.
    Kidney, Renal tubule - Atypical tubule hyperplasia in a male F344/N rat from a chronic study. This larger focus of tubule hyperplasia contains three cross sections of presumably the same tubule.
    Kidney, Renal tubule - Atypical tubule hyperplasia in a male F344/N rat from a chronic study. This larger focus of tubule hyperplasia contains three cross sections of presumably the same tubule.
    Kidney, Renal tubule - Atypical tubule hyperplasia in a female F344/N rat from a chronic study. Early proliferation of epithelial cells indicates atypical tubule hyperplasia.
    Kidney, Renal tubule - Atypical tubule hyperplasia in a female F344/N rat from a chronic study. Early proliferation of epithelial cells indicates atypical tubule hyperplasia.

    Authors 

    John Curtis Seely, DVM, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Kendall S. Frazier, DVM, PhD, DACVP, DABT
    Director, Cellular and Molecular Pathology, Safety Assessment
    GlaxoSmithKline
    King of Prussia, PA

    Gordon C. Hard, BSc, BVSc, PhD, DSc, FRCPath, FRCVS, FAToxSci, DACVP
    Expert Consultant
    Tairua, New Zealand

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC