Cardiovascular System

Blood Vessel - Proliferation, Intimal

    Narrative
    Heart, Artery - Proliferation, Intimal in a male F344/N rat from a chronic study. The wall of an artery in the heart is thickened (arrow).
    Heart, Artery - Proliferation, Intimal in a male F344/N rat from a chronic study. The wall of an artery in the heart is thickened (arrow).
    Heart, Artery - Proliferation, Intimal in a male F344/N rat from a chronic study (higher magnification of Figure 1). There is a distinct demarcation between the thickened tunica intima and the tunica media (arrows).
    Heart, Artery - Proliferation, Intimal in a male F344/N rat from a chronic study (higher magnification of Figure 1). There is a distinct demarcation between the thickened tunica intima and the tunica media (arrows).
    Liver, Artery - Proliferation, Intimal in a female F344/N rat from a subchronic study. There is segmental thickening of a large artery (arrow).
    Liver, Artery - Proliferation, Intimal in a female F344/N rat from a subchronic study. There is segmental thickening of a large artery (arrow).
    Liver, Artery - Proliferation, Intimal proliferation in a female F344/N rat from a subchronic study (higher magnification of Figure 3). The intimal proliferation (arrow) is causing partial occlusion of the arterial lumen.
    Liver, Artery - Proliferation, Intimal proliferation in a female F344/N rat from a subchronic study (higher magnification of Figure 3). The intimal proliferation (arrow) is causing partial occlusion of the arterial lumen.
    Heart, Artery - Proliferation, Intimal in a male F344/N rat from a chronic study. The junction between tunica media and the tunica intima (arrows) is distinct.
    Heart, Artery - Proliferation, Intimal in a male F344/N rat from a chronic study. The junction between tunica media and the tunica intima (arrows) is distinct.
    Liver, Artery - Proliferation, Intimal in a male F344/N rat from a chronic study. The line of demarcation between the proliferating tunica intima and the tunica media (arrows) is conspicuous.
    Liver, Artery - Proliferation, Intimal in a male F344/N rat from a chronic study. The line of demarcation between the proliferating tunica intima and the tunica media (arrows) is conspicuous.

    Authors:

    Crystal L. Johnson, DVM, DACVP
    Veterinary Pathologist II
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Paul W. Snyder, DVM, PhD, Diplomate ACVP, Fellow IATP
    Manager, EPL Midwest
    Senior Pathologist
    Experimental Pathology Laboratories, Inc. 
    West Lafayette, IN

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC