Urinary System

Kidney, Glomerulus - Metaplasia

    Narrative
    Kidney, Glomerulus - Normal in a female B6C3F1 mouse from a subchronic study. The parietal epithelial cells lining the glomerulus of the female mouse are normally flattened (arrow).
    Kidney, Glomerulus - Normal in a female B6C3F1 mouse from a subchronic study. The parietal epithelial cells lining the glomerulus of the female mouse are normally flattened (arrow).
    Kidney, Glomerulus - Metaplasia in a female B6C3F1 mouse from a chronic study. Metaplasia is characterized by a change from the flattened parietal epithelium to cuboidal epithelium (arrow).
    Kidney, Glomerulus - Metaplasia in a female B6C3F1 mouse from a chronic study. Metaplasia is characterized by a change from the flattened parietal epithelium to cuboidal epithelium (arrow).

    Authors 

    John Curtis Seely, DVM, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Kendall S. Frazier, DVM, PhD, DACVP, DABT
    Director, Cellular and Molecular Pathology, Safety Assessment
    GlaxoSmithKline
    King of Prussia, PA

    Gordon C. Hard, BSc, BVSc, PhD, DSc, FRCPath, FRCVS, FAToxSci, DACVP
    Expert Consultant
    Tairua, New Zealand

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC