Urinary System

Kidney, Renal Tubule - Degeneration

    Narrative
    Kidney, Renal tubule - Degeneration in a male Tg.Ac (FVB/N) hemizygous mouse from a subchronic study. The degeneration of cortical tubule epithelial cells is characterized by vacuolation of the cytoplasm and pyknosis of the nuclei.
    Kidney, Renal tubule - Degeneration in a male Tg.Ac (FVB/N) hemizygous mouse from a subchronic study. The degeneration of cortical tubule epithelial cells is characterized by vacuolation of the cytoplasm and pyknosis of the nuclei.
    Kidney, Renal tubule - Degeneration in a female F344/N rat from a subchronic study. In this case, the degeneration is characterized by tubule cells with an eosinophilic tinctorial change and cytoplasmic vacuolation.
    Kidney, Renal tubule - Degeneration in a female F344/N rat from a subchronic study. In this case, the degeneration is characterized by tubule cells with an eosinophilic tinctorial change and cytoplasmic vacuolation.

    Authors 

    John Curtis Seely, DVM, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Kendall S. Frazier, DVM, PhD, DACVP, DABT
    Director, Cellular and Molecular Pathology, Safety Assessment
    GlaxoSmithKline
    King of Prussia, PA

    Gordon C. Hard, BSc, BVSc, PhD, DSc, FRCPath, FRCVS, FAToxSci, DACVP
    Expert Consultant
    Tairua, New Zealand

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC