Immune System

Thymus - Necrosis, Lymphocyte

    Narrative
    Thymus - Necrosis, Lymphocyte in a male Harlan Sprague-Dawley rat from a subchronic study. Treatment with dexamethasone resulted in severe lymphocyte apoptosis with focal areas of necrosis.
    Thymus - Necrosis, Lymphocyte in a male Harlan Sprague-Dawley rat from a subchronic study. Treatment with dexamethasone resulted in severe lymphocyte apoptosis with focal areas of necrosis.
    Thymus - Necrosis, Lymphocyte in a male Harlan Sprague-Dawley rat from a subchronic study (higher magnification of Figure 1). Lymphocyte necrosis (arrows) is accompanied by eosinophilic cytoplasmic debris, basophilic nuclear debris, mineral (arrowhead), and inflammation.
    Thymus - Necrosis, Lymphocyte in a male Harlan Sprague-Dawley rat from a subchronic study (higher magnification of Figure 1). Lymphocyte necrosis (arrows) is accompanied by eosinophilic cytoplasmic debris, basophilic nuclear debris, mineral (arrowhead), and inflammation.

    Authors

    Kristen Hobbie, DVM, PhD
    Principal Pathologist
    Huntingdon Life Sciences
    Peterborough, UK

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Holly M. Kolenda-Roberts, DVM, PhD, DACVP
    Veterinary Pathologist
    SNBL USA
    Everett, WA

    Reviewers

    Jerrold M. Ward, DVM, PhD, DACVP, FIATP
    Veterinary Pathologist
    Global VetPathology
    Montgomery Village, MD

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC