Respiratory System

Nose - Hyperplasia, Goblet Cell

    Narrative
    Nose, Respiratory epithelium - Hyperplasia, Goblet cell in a male F344/N rat from a chronic study. Goblet cells are increased in number in the epithelium lining the nasal septum.
    Nose, Respiratory epithelium - Hyperplasia, Goblet cell in a male F344/N rat from a chronic study. Goblet cells are increased in number in the epithelium lining the nasal septum.
    Nose, Respiratory epithelium - Hyperplasia, Goblet cell in a male F344/N rat from a chronic study. Goblet cells are increased in number in the epithelium on one side of the nasal septum (top); the opposite side is lined by metaplastic squamous epithelium.
    Nose, Respiratory epithelium - Hyperplasia, Goblet cell in a male F344/N rat from a chronic study. Goblet cells are increased in number in the epithelium on one side of the nasal septum (top); the opposite side is lined by metaplastic squamous epithelium.
    Nose, Respiratory epithelium - Hyperplasia, Goblet cell (right) and normal respiratory epithelium (left) of the nasopharyngeal duct in a male F344/N rat from a subchronic study. Image provided courtesy of Dr. R. Miller.
    Nose, Respiratory epithelium - Hyperplasia, Goblet cell (right) and normal respiratory epithelium (left) of the nasopharyngeal duct in a male F344/N rat from a subchronic study. Image provided courtesy of Dr. R. Miller.
    Nose, Respiratory epithelium - Hyperplasia, Goblet cell in the nasopharyngeal duct in a male F344/N rat from a subchronic study. Hematoxylin and eosin staining of goblet cell hyperplasia is on the left, and periodic acid-Schiff staining is on the right. Image provided courtesy of Dr. R. Miller., basic_html
    Nose, Respiratory epithelium - Hyperplasia, Goblet cell in the nasopharyngeal duct in a male F344/N rat from a subchronic study. Hematoxylin and eosin staining of goblet cell hyperplasia is on the left, and periodic acid-Schiff staining is on the right. Image provided courtesy of Dr. R. Miller., basic_html
    Nose, Transitional epithelium - Hyperplasia, Goblet cell in a male F344/N rat from a chronic study. Increased numbers of goblet cells are present in the epithelium lining the turbinate, with coalescence of goblet cells on one side of the turbinate (arrow).
    Nose, Transitional epithelium - Hyperplasia, Goblet cell in a male F344/N rat from a chronic study. Increased numbers of goblet cells are present in the epithelium lining the turbinate, with coalescence of goblet cells on one side of the turbinate (arrow).

    Authors

    Rodney A. Miller, DVM, PhD, DACVP
    NC Pathology Group Manager
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Ronald Herbert, DVM, PhD
    NTP Pathologist
    Group Leader, Pathology Support Group
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC