Urinary System

Kidney, Renal Tubule - Hyperplasia, Oncocytic

Narrative
Comment:
Oncocytic hyperplasia is characterized by tubule cells having lightly staining and finely granular cytoplasm with centralized nuclei. Oncocytic hyperplasia is a rare lesion in the rat and mouse (Figure 1) and reportedly originates in the collecting tubule. Ultrastructurally, oncocytes are composed of atypical mitochondria. Oncocytic hyperplasia is difficult to separate from oncocytoma and should be scored separately from other hyperplastic lesions of the renal tubule.
Recommendations:
Oncocytic hyperplasia should be diagnosed and given a severity grade.
Related Links:
Kidney - Renal Tubule - Hyperplasia, Amphophilic-Vacuolar
Kidney - Renal Tubule - Atypical Tubule Hyperplasia
References:

Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, Bube A. 2012. Proliferative and non-proliferative lesions in the rat and mouse urinary system. Toxicol Pathol 40:14S-86S.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22637735
  • Image of renal tubule hyperplasia, oncocytic in the kidney from a male F344/N rat in a chronic study

    Kidney, Renal tubule - Hyperplasia, Oncocytic in a male F344/N rat from a chronic study. Oncocytic hyperplasia represents an increased number of tubule epithelial cells characterized by cytoplasmic enlargement due to the presence of lightly staining, finely granular cytoplasm and centralized nuclei (oncocytes).

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<p>Kidney, Renal tubule - Hyperplasia, Oncocytic in a male F344/N rat from a chronic study. Oncocytic hyperplasia represents an increased number of tubule epithelial cells characterized by cytoplasmic enlargement due to the presence of lightly staining, finely granular cytoplasm and centralized nuclei (oncocytes).</p>

Kidney, Renal tubule - Hyperplasia, Oncocytic in a male F344/N rat from a chronic study. Oncocytic hyperplasia represents an increased number of tubule epithelial cells characterized by cytoplasmic enlargement due to the presence of lightly staining, finely granular cytoplasm and centralized nuclei (oncocytes).

Authors 

John Curtis Seely, DVM, DACVP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Amy Brix, DVM, PhD, DACVP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Reviewers

Kendall S. Frazier, DVM, PhD, DACVP, DABT
Director, Cellular and Molecular Pathology, Safety Assessment
GlaxoSmithKline
King of Prussia, PA

Gordon C. Hard, BSc, BVSc, PhD, DSc, FRCPath, FRCVS, FAToxSci, DACVP
Expert Consultant
Tairua, New Zealand

Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
Staff Scientist, NTP Pathologist
NTP Pathology Group
National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC