Urinary System

Kidney, Renal Tubule - Hyperplasia, Oncocytic

    Narrative
    Kidney, Renal tubule - Hyperplasia, Oncocytic in a male F344/N rat from a chronic study. Oncocytic hyperplasia represents an increased number of tubule epithelial cells characterized by cytoplasmic enlargement due to the presence of lightly staining, finely granular cytoplasm and centralized nuclei (oncocytes).
    Kidney, Renal tubule - Hyperplasia, Oncocytic in a male F344/N rat from a chronic study. Oncocytic hyperplasia represents an increased number of tubule epithelial cells characterized by cytoplasmic enlargement due to the presence of lightly staining, finely granular cytoplasm and centralized nuclei (oncocytes).

    Authors 

    John Curtis Seely, DVM, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Kendall S. Frazier, DVM, PhD, DACVP, DABT
    Director, Cellular and Molecular Pathology, Safety Assessment
    GlaxoSmithKline
    King of Prussia, PA

    Gordon C. Hard, BSc, BVSc, PhD, DSc, FRCPath, FRCVS, FAToxSci, DACVP
    Expert Consultant
    Tairua, New Zealand

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC