Cardiovascular System

Heart - Mineral

    Narrative
    Heart - Mineral in a male F344/N rat from a chronic study. Dark blue crystalline material is present in the myocardium (arrows).
    Heart - Mineral in a male F344/N rat from a chronic study. Dark blue crystalline material is present in the myocardium (arrows).
    Heart - Mineral in a male F344/N rat from a chronic study (higher magnification of Figure 1). The dark blue mineral (arrow) in the cardiomyocytes is associated with a region of fibrosis.
    Heart - Mineral in a male F344/N rat from a chronic study (higher magnification of Figure 1). The dark blue mineral (arrow) in the cardiomyocytes is associated with a region of fibrosis.
    Heart - Mineral in a female B6C3F1/N mouse from a subchronic study. Focal areas of mineral are present in the myocardium (arrows).
    Heart - Mineral in a female B6C3F1/N mouse from a subchronic study. Focal areas of mineral are present in the myocardium (arrows).
    Heart - Mineral in a female B6C3F1/N mouse from a subchronic study (higher magnification of Figure 3). There is blue mineral within the cardiomyocytes.
    Heart - Mineral in a female B6C3F1/N mouse from a subchronic study (higher magnification of Figure 3). There is blue mineral within the cardiomyocytes.

    Authors:

    Crystal L. Johnson, DVM, DACVP
    Veterinary Pathologist II
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Brian Berridge, DVM, PhD, DACVP
    Director, WW Animal Research Strategy
    GlaxoSmithKline R&D
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC