Hematopoietic System

Bone Marrow - Inflammation

    Narrative
    Bone marrow in a male F344/N rat from a chronic study. This low-power view shows relatively pale eosinophilic areas of granulomatous inflammation consisting of aggregates of macrophages (arrows).
    Bone marrow in a male F344/N rat from a chronic study. This low-power view shows relatively pale eosinophilic areas of granulomatous inflammation consisting of aggregates of macrophages (arrows).
    Bone marrow in a male F344/N male rat from a chronic study (higher magnification of Figure 1), showing several aggregates of macrophages (arrows), some epithelioid and/or multinucleated.
    Bone marrow in a male F344/N male rat from a chronic study (higher magnification of Figure 1), showing several aggregates of macrophages (arrows), some epithelioid and/or multinucleated.
    Bone marrow in a male B6C3F1 mouse from a chronic study showing a distinct granuloma (arrows).
    Bone marrow in a male B6C3F1 mouse from a chronic study showing a distinct granuloma (arrows).
    Bone marrow in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 3), showing a distinct granuloma.
    Bone marrow in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 3), showing a distinct granuloma.
    Bone marrow in a male B6C3F1 mouse from a chronic study, showing severe suppurative inflammation with high numbers of degenerative neutrophils mixed with necrotic debris.
    Bone marrow in a male B6C3F1 mouse from a chronic study, showing severe suppurative inflammation with high numbers of degenerative neutrophils mixed with necrotic debris.
    Bone marrow in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 5), showing severe suppurative inflammation with high numbers of degenerative neutrophils mixed with necrotic debris.
    Bone marrow in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 5), showing severe suppurative inflammation with high numbers of degenerative neutrophils mixed with necrotic debris.

    Authors

    Michelle C. Cora, DVM, DACVP
    Veterinary Medical Officer
    NTP Clinical Pathologist
    NTP Clinical Pathology Group
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Gregory Travlos, DVM, DACVP
    Group Leader, Clinical Pathology Group
    Cellular and Molecular Pathology Branch
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Armando R. Irizarry, DVM, PHD, DACVP
    Adjunct Associate Professor of Veterinary Anatomic and Clinical Pathology
    Department of Comparative Pathobiology
    Purdue University College of Veterinary Medicine
    West Lafayette, IN

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC