Endocrine System

Adrenal Gland, Cortex - Atrophy

    Narrative
    Adrenal gland, Cortex - Atrophy in a female Sprague-Dawley rat from a chronic study. The width of the cortex (C) and the overall size of the gland are decreased; the capsule (arrow) is thickened by fibrosis. M = medulla.
    Adrenal gland, Cortex - Atrophy in a female Sprague-Dawley rat from a chronic study. The width of the cortex (C) and the overall size of the gland are decreased; the capsule (arrow) is thickened by fibrosis. M = medulla.
    Adrenal gland, Cortex - Atrophy in a female Sprague-Dawley rat from a chronic study (higher magnification of Figure 1). The width of the zona fasciculata is decreased, and the cell nuclei in the outer zona fasciculata are crowded, suggesting a decrease in size. C = cortex, M = medulla.
    Adrenal gland, Cortex - Atrophy in a female Sprague-Dawley rat from a chronic study (higher magnification of Figure 1). The width of the zona fasciculata is decreased, and the cell nuclei in the outer zona fasciculata are crowded, suggesting a decrease in size. C = cortex, M = medulla.
    Adrenal gland, Cortex - Normal in a female Sprague-Dawley rat from a chronic study. A normal adrenal gland at the same magnification as Figure 1 is shown for comparison. C = cortex, M = medulla.
    Adrenal gland, Cortex - Normal in a female Sprague-Dawley rat from a chronic study. A normal adrenal gland at the same magnification as Figure 1 is shown for comparison. C = cortex, M = medulla.
    Adrenal gland, Cortex - Normal in a female Sprague-Dawley rat from a chronic study. A normal adrenal gland at the same magnification as Figure 2 is shown for comparison. C = cortex, M = medulla.
    Adrenal gland, Cortex - Normal in a female Sprague-Dawley rat from a chronic study. A normal adrenal gland at the same magnification as Figure 2 is shown for comparison. C = cortex, M = medulla.

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    Veterinary Pathologist, In Vivo Animal Core
    Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Georgette D. Hill, D.V.M., Ph.D.
    Toxicologic Pathologist/Assistant Pathology Program Manager
    Comparative Molecular Pathology Division
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Margarita M. Gruebbel, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Thomas J. Rosol, DVM, PhD, DACVP
    Professor of Veterinary Biosciences
    Senior Advisor, Life Sciences, Technology Commercialization and Knowledge Transfer
    The Ohio State University
    Columbus, OH

    Gordon Flake, MD
    Staff Scientist
    NTP Pathologist
    Cellular and Molecular Pathology Branch
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC